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Novel Criteria for the Observe-Zone of the ESC 0/1 h-hs-cTnT Algorithm
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- Lopez-Ayala, Pedro (författare)
- Univ Basel, Univ Basel Hosp, Cardiovasc Res Inst Basel, Basel, Switzerland.;Univ Basel, Univ Basel Hosp, Dept Cardiol, Basel, Switzerland.;Global Res Acute Condit Team Network, Rome, Italy.
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- Nestelberger, Thomas (författare)
- Univ Basel, Univ Basel Hosp, Cardiovasc Res Inst Basel, Basel, Switzerland.;Univ Basel, Univ Basel Hosp, Dept Cardiol, Basel, Switzerland.;Global Res Acute Condit Team Network, Rome, Italy.;Univ British Columbia, Vancouver Gen Hosp, Div Cardiol, Vancouver, BC, Canada.
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- Boeddinghaus, Jasper (författare)
- Univ Basel, Univ Basel Hosp, Cardiovasc Res Inst Basel, Basel, Switzerland.;Univ Basel, Univ Basel Hosp, Dept Cardiol, Basel, Switzerland.;Global Res Acute Condit Team Network, Rome, Italy.
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- Univ Basel, Univ Basel Hosp, Cardiovasc Res Inst Basel, Basel, Switzerland;Univ Basel, Univ Basel Hosp, Dept Cardiol, Basel, Switzerland.;Global Res Acute Condit Team Network, Rome, Italy. Univ Basel, Univ Basel Hosp, Cardiovasc Res Inst Basel, Basel, Switzerland.;Univ Basel, Univ Basel Hosp, Dept Cardiol, Basel, Switzerland.;Global Res Acute Condit Team Network, Rome, Italy.;Univ British Columbia, Vancouver Gen Hosp, Div Cardiol, Vancouver, BC, Canada. (creator_code:org_t)
- Wolters Kluwer, 2021
- 2021
- Engelska.
- Ingår i: Circulation. - : Wolters Kluwer. - 0009-7322 .- 1524-4539. ; 144:10, s. 773-787
- Tidskriftsartikel (refereegranskat)
Abstract
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- BACKGROUND: The non-ST-segment-elevation myocardial infarction (NSTEMI) guidelines of the European Society of Cardiology (ESC) recommend a 3h cardiac troponin determination in patients triaged to the observe-zone of the ESC 0/1h-algorithm; however, no specific cutoff for further triage is endorsed. Recently, a specific cutoff for 0/3h high-sensitivity cardiac troponin T (hs-cTnT) change (7 ng/L) was proposed, warranting external validation. METHODS: Patients presenting with acute chest discomfort to the emergency department were prospectively enrolled into an international multicenter diagnostic study. Final diagnoses were centrally adjudicated by 2 independent cardiologists applying the fourth universal definition of myocardial infarction, on the basis of complete cardiac workup, cardiac imaging, and serial hs-cTnT. Hs-cTnT concentrations were measured at presentation, after 1 hour, and after 3 hours. The objective was to externally validate the proposed cutoff, and if necessary, derive and internally as well as externally validate novel 0/3h-criteria for the observe-zone of the ESC 0/1h-hs-cTnT-algorithm in an independent multicenter cohort. RESULTS: Among 2076 eligible patients, application of the ESC 0/1h-hs-cTnT-algorithm triaged 1512 patients (72.8%) to either rule out or rule in NSTEMI, leaving 564 patients (27.2%) in the observe-zone (adjudicated NSTEMI prevalence, 120/564 patients, 21.3%). The suggested 0/3h-hs-cTnT-change of <7 ng/L triaged 517 patients (91.7%) toward rule-out, resulting in a sensitivity of 33.3% (95% CI, 25.5-42.2), missing 80 patients with NSTEMI, and >= 7 ng/L triaged 47 patients toward rule-in (8.3%), resulting in a specificity of 98.4% (95% CI, 96.8-99.2). Novel derived 0/3h-criteria for the observe-zone patients ruled out NSTEMI with a 3h hs-cTnT concentration <15 ng/L and a 0/3h-hs-cTnT absolute change <4 ng/L, triaging 138 patients (25%) toward rule-out, resulting in a sensitivity of 99.2% (95% CI, 96.0-99.9), missing 1 patient with NSTEMI. A 0/3h-hs-cTnT absolute change >= 6 ng/L triaged 63 patients (11.2%) toward rule-in, resulting in a specificity of 98% (95% CI, 96.2-98.9) Thereby, the novel 0/3h-criteria reduced the number of patients in the observe zone by 36%s and the number of type 1 myocardial infarction by 50%. Findings were confirmed in both internal and external validation. CONCLUSIONS: A combination of a 3h-hs-cTnT concentration (<15 ng/L) and a 0/3h absolute change (<4 ng/L) is necessary to safely rule out NSTEMI in patients remaining in the observe-zone of the ESC 0/1h-hs-cTnT-algorithm.
Ämnesord
- MEDICIN OCH HÄLSOVETENSKAP -- Klinisk medicin -- Kardiologi (hsv//swe)
- MEDICAL AND HEALTH SCIENCES -- Clinical Medicine -- Cardiac and Cardiovascular Systems (hsv//eng)
Nyckelord
- algorithms
- biomarkers
- myocardial infarction
- NSTEMI
- triage
- troponin
- troponin T
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