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Common variation at 3q26.2, 6p21.33, 17p11.2 and 22q13.1 influences multiple myeloma risk
- Chubb, Daniel (author)
- Weinhold, Niels (author)
- Broderick, Peter (author)
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- Chen, Bowang (author)
- Johnson, David C. (author)
- Vijayakrishnan, Jayaram (author)
- Migliorini, Gabriele (author)
- Dobbins, Sara E. (author)
- Holroyd, Amy (author)
- Hose, Dirk (author)
- Walker, Brian A. (author)
- Davies, Faith E. (author)
- Gregory, Walter A. (author)
- Jackson, Graham H. (author)
- Irving, Julie A. (author)
- Pratt, Guy (author)
- Fegan, Chris (author)
- Fenton, James A. L. (author)
- Neben, Kai (author)
- Hoffmann, Per (author)
- Noethen, Markus M. (author)
- Muehleisen, Thomas W. (author)
- Eisele, Lewin (author)
- Ross, Fiona M. (author)
- Straka, Christian (author)
- Einsele, Hermann (author)
- Langer, Christian (author)
- Doerner, Elisabeth (author)
- Allan, James M. (author)
- Jauch, Anna (author)
- Morgan, Gareth J. (author)
- Hemminki, Kari (author)
- Houlston, Richard S. (author)
- Goldschmidt, Hartmut (author)
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- (creator_code:org_t)
- 2013-08-18
- 2013
- English.
- In: Nature Genetics. - : Springer Science and Business Media LLC. - 1546-1718 .- 1061-4036. ; 45:10, s. 366-1221
- Journal article (peer-reviewed)
Abstract
Subject headings
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- To identify variants for multiple myeloma risk, we conducted a genome-wide association study with validation in additional series totaling 4,692 individuals with multiple myeloma (cases) and 10,990 controls. We identified four risk loci at 3q26.2 (rs10936599, P = 8.70 x 10(-14)), 6p21.33 (rs2285803, PSORS1C2, P = 9.67 x 10(-11)), 17p11.2 (rs4273077, TNFRSF13B, P = 7.67 x 10(-9)) and 22q13.1 (rs877529, CBX7, P = 7.63 x 10(-16)). These data provide further evidence for genetic susceptibility to this B-cell hematological malignancy, as well as insight into the biological basis of predisposition.
Subject headings
- MEDICIN OCH HÄLSOVETENSKAP -- Hälsovetenskap -- Folkhälsovetenskap, global hälsa, socialmedicin och epidemiologi (hsv//swe)
- MEDICAL AND HEALTH SCIENCES -- Health Sciences -- Public Health, Global Health, Social Medicine and Epidemiology (hsv//eng)
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