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Corticostriatal Whi...
Corticostriatal White Matter Integrity and Dopamine D1 Receptor Availability Predict Age Differences in Prefrontal Value Signaling during Reward Learning
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- de Boer, Lieke (författare)
- Stockholms universitet,Centrum för forskning om äldre och åldrande (ARC), (tills m KI)
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- Garzón, Benjamín (författare)
- Karolinska Institutet,Stockholms universitet,Centrum för forskning om äldre och åldrande (ARC), (tills m KI)
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- Axelsson, Jan, 1966- (författare)
- Umeå universitet,Fysiologi,Department of Radiation Sciences, Diagnostic Radiology, University Hospital, Umeå University, Umeå, Sweden
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- Riklund, Katrine, MD, PhD, Professor, 1963- (författare)
- Umeå universitet,Fysiologi,Department of Radiation Sciences, Diagnostic Radiology, University Hospital, Umeå University, Umeå, Sweden
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- Nyberg, Lars, 1966- (författare)
- Umeå universitet,Umeå centrum för funktionell hjärnavbildning (UFBI),Fysiologi,Department of Radiation Sciences, Diagnostic Radiology, University Hospital, Umeå University, Umeå, Sweden
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- Bäckman, Lars (författare)
- Karolinska Institutet,Stockholms universitet,Centrum för forskning om äldre och åldrande (ARC), (tills m KI)
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- Guitart-Masip, Marc (författare)
- Karolinska Institutet,Stockholms universitet,Centrum för forskning om äldre och åldrande (ARC), (tills m KI),University College London, UK
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(creator_code:org_t)
- 2020-06-02
- 2020
- Engelska.
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Ingår i: Cerebral Cortex. - : Oxford University Press (OUP). - 1047-3211 .- 1460-2199. ; 30:10, s. 5270-5280
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Abstract
Ämnesord
Stäng
- Probabilistic reward learning reflects the ability to adapt choices based on probabilistic feedback. The dopaminergically innervated corticostriatal circuit in the brain plays an important role in supporting successful probabilistic reward learning. Several components of the corticostriatal circuit deteriorate with age, as it does probabilistic reward learning. We showed previously that D1 receptor availability in NAcc predicts the strength of anticipatory value signaling in vmPFC, a neural correlate of probabilistic learning that is attenuated in older participants and predicts probabilistic reward learning performance. We investigated how white matter integrity in the pathway between nucleus accumbens (NAcc) and ventromedial prefrontal cortex (vmPFC) relates to the strength of anticipatory value signaling in vmPFC in younger and older participants. We found that in a sample of 22 old and 23 young participants, fractional anisotropy in the pathway between NAcc and vmPFC predicted the strength of value signaling in vmPFC independently from D1 receptor availability in NAcc. These findings provide tentative evidence that integrity in the dopaminergic and white matter pathways of corticostriatal circuitry supports the expression of value signaling in vmPFC which supports reward learning, however, the limited sample size calls for independent replication. These and future findings could add to the improved understanding of how corticostriatal integrity contributes to reward learning ability.
Ämnesord
- MEDICIN OCH HÄLSOVETENSKAP -- Medicinska och farmaceutiska grundvetenskaper -- Neurovetenskaper (hsv//swe)
- MEDICAL AND HEALTH SCIENCES -- Basic Medicine -- Neurosciences (hsv//eng)
Nyckelord
- aging
- corticostriatal loops
- dopamine
- value-based decision making
- white matter integrity
Publikations- och innehållstyp
- ref (ämneskategori)
- art (ämneskategori)
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