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In vivo coupling of...
In vivo coupling of tau pathology and cortical thinning in Alzheimer's disease
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- Mak, Elijah (author)
- Department of Psychiatry, University of Cambridge, Cambridge, UK
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- Bethlehem, Richard A I (author)
- Department of Psychiatry, University of Cambridge, Cambridge, UK
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- Romero-Garcia, Rafael (author)
- Department of Psychiatry, University of Cambridge, Cambridge, UK
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- Cervenka, Simon (author)
- Karolinska Institutet
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- Rittman, Timothy (author)
- Department of Clinical Neurosciences, University of Cambridge, Cambridge, UK
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- Gabel, Silvy (author)
- Department of Psychiatry, University of Cambridge, Cambridge, UK; Laboratory for Cognitive Neurology, University of Leuven, Leuven, Belgium
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- Surendranathan, Ajenthan (author)
- Department of Psychiatry, University of Cambridge, Cambridge, UK
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- Bevan-Jones, Richard W (author)
- Department of Psychiatry, University of Cambridge, Cambridge, UK
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- Passamonti, Luca (author)
- Department of Clinical Neurosciences, University of Cambridge, Cambridge, UK
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- Vázquez Rodríguez, Patricia (author)
- Department of Clinical Neurosciences, University of Cambridge, Cambridge, UK
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- Su, Li (author)
- Department of Psychiatry, University of Cambridge, Cambridge, UK; China‐UK Centre for Cognition and Ageing Research, Southwest University, Chongqing, China
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- Arnold, Robert (author)
- Department of Psychiatry, University of Cambridge, Cambridge, UK
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- Williams, Guy B (author)
- Wolfson Brain Imaging Centre, University of Cambridge, Cambridge, UK
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- Hong, Young T (author)
- Department of Clinical Neurosciences, University of Cambridge, Cambridge, UK; Wolfson Brain Imaging Centre, University of Cambridge, Cambridge, UK
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- Fryer, Tim D (author)
- Department of Clinical Neurosciences, University of Cambridge, Cambridge, UK; Wolfson Brain Imaging Centre, University of Cambridge, Cambridge, UK
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- Aigbirhio, Franklin I (author)
- Department of Clinical Neurosciences, University of Cambridge, Cambridge, UK; Wolfson Brain Imaging Centre, University of Cambridge, Cambridge, UK
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- Rowe, James B (author)
- Medical Research Council, and Brain Sciences Unit, Cambridge, UK; Behavioural and Clinical Neuroscience Institute, University of Cambridge, Cambridge, UK
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- O'Brien, John T (author)
- Department of Psychiatry, University of Cambridge, Cambridge, UK
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(creator_code:org_t)
- 2018-09-17
- 2018
- English.
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In: Alzheimer's & dementia (Amsterdam, Netherlands). - : Wiley. - 2352-8729. ; 10, s. 678-687
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Abstract
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- Introduction: The deposition of neurofibrillary tangles in neurodegenerative disorders is associated with neuronal loss on autopsy; however, their in vivo associations with atrophy across the continuum of Alzheimer's disease (AD) remain unclear.Methods: We estimated cortical thickness, tau ([18F]-AV-1451), and amyloid β (Aβ) status ([11C]-PiB) in 47 subjects who were stratified into Aβ- (14 healthy controls and six mild cognitive impairment-Aβ-) and Aβ+ (14 mild cognitive impairment-Aβ+ and 13 AD) groups.Results: Compared with the Aβ- group, tau was increased in widespread regions whereas cortical thinning was restricted to the temporal cortices. Increased tau binding was associated with cortical thinning in each Aβ group. Locally, regional tau was associated with temporoparietal atrophy.Discussion: These findings position tau as a promising therapeutic target. Further studies are needed to elucidate the casual relationships between tau pathology and trajectories of atrophy in AD.
Subject headings
- MEDICIN OCH HÄLSOVETENSKAP -- Klinisk medicin -- Neurologi (hsv//swe)
- MEDICAL AND HEALTH SCIENCES -- Clinical Medicine -- Neurology (hsv//eng)
- MEDICIN OCH HÄLSOVETENSKAP -- Medicinska och farmaceutiska grundvetenskaper -- Neurovetenskaper (hsv//swe)
- MEDICAL AND HEALTH SCIENCES -- Basic Medicine -- Neurosciences (hsv//eng)
Keyword
- Alzheimer's disease
- Amyloid
- Atrophy
- Cortical thickness
- MRI
- Positron emission tomography
- Tau
Publication and Content Type
- ref (subject category)
- art (subject category)
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- By the author/editor
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Mak, Elijah
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Bethlehem, Richa ...
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Romero-Garcia, R ...
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Cervenka, Simon
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Rittman, Timothy
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Gabel, Silvy
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show more...
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Surendranathan, ...
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Bevan-Jones, Ric ...
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Passamonti, Luca
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Vázquez Rodrígue ...
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Su, Li
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Arnold, Robert
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Williams, Guy B
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Hong, Young T
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Fryer, Tim D
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Aigbirhio, Frank ...
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Rowe, James B
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O'Brien, John T
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- About the subject
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- MEDICAL AND HEALTH SCIENCES
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MEDICAL AND HEAL ...
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and Clinical Medicin ...
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and Neurology
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- MEDICAL AND HEALTH SCIENCES
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MEDICAL AND HEAL ...
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and Basic Medicine
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and Neurosciences
- Articles in the publication
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Alzheimer's & de ...
- By the university
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Uppsala University
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Karolinska Institutet