Search: WFRF:(O'Rahilly Stephen P.) >
A Deletion in the C...
A Deletion in the Canine POMC Gene Is Associated with Weight and Appetite in Obesity-Prone Labrador Retriever Dogs
-
- Raffan, Eleanor (author)
- Univ Cambridge, WT MRC Inst Metab Sci, Metab Res Labs, Cambridge CB2 0QQ, England.
-
- Dennis, Rowena J. (author)
- Univ Cambridge, WT MRC Inst Metab Sci, Metab Res Labs, Cambridge CB2 0QQ, England.
-
- O'Donovan, Conor J. (author)
- Univ Cambridge, WT MRC Inst Metab Sci, Metab Res Labs, Cambridge CB2 0QQ, England.
-
show more...
-
- Becker, Julia M. (author)
- Univ Cambridge, WT MRC Inst Metab Sci, Metab Res Labs, Cambridge CB2 0QQ, England.
-
- Scott, Robert A. (author)
- Univ Cambridge, WT MRC Inst Metab Sci, MRC Epidemiol Unit, Cambridge CB2 0QQ, England.
-
- Smith, Stephen P. (author)
- Univ Cambridge, Sch Clin Med, Cambridge CB2 0SP, England.
-
- Withers, David J. (author)
- Univ Cambridge, WT MRC Inst Metab Sci, Metab Res Labs, Cambridge CB2 0QQ, England.
-
- Wood, Claire J. (author)
- Univ Cambridge, WT MRC Inst Metab Sci, Metab Res Labs, Cambridge CB2 0QQ, England.
-
- Conci, Elena (author)
- Univ Cambridge, WT MRC Inst Metab Sci, Metab Res Labs, Cambridge CB2 0QQ, England.
-
- Clements, Dylan N. (author)
- Univ Edinburgh, Roslin Inst, Easter Bush EH25 9RG, Midlothian, Scotland.;Univ Edinburgh, Royal Dick Sch Vet Studies, Easter Bush EH25 9RG, Midlothian, Scotland.
-
- Summers, Kim M. (author)
- Univ Edinburgh, Roslin Inst, Easter Bush EH25 9RG, Midlothian, Scotland.
-
- German, Alexander J. (author)
- Univ Liverpool, Inst Ageing & Chron Dis, Neston CH64 7TE, Cheshire, England.
-
- Mellersh, Cathryn S. (author)
- Anim Hlth Trust, Dept Canine Genet, Newmarket CB8 7UU, Suffolk, England.
-
- Arendt, Maja L. (author)
- Uppsala universitet,Institutionen för medicinsk biokemi och mikrobiologi
-
- Iyemere, Valentine P. (author)
- Univ Cambridge, WT MRC Inst Metab Sci, Metab Res Labs, Cambridge CB2 0QQ, England.
-
- Withers, Elaine (author)
- Univ Cambridge, WT MRC Inst Metab Sci, Metab Res Labs, Cambridge CB2 0QQ, England.
-
- Söder, Josefin (author)
- Swedish University of Agricultural Sciences,Sveriges lantbruksuniversitet,Institutionen för anatomi, fysiologi och biokemi,Department of Anatomy, Physiology and Biochemistry (AFB),Swedish Univ Agr Sci, Dept Anat Physiol & Biochem, S-75007 Uppsala, Sweden.
-
- Wernersson, Sara (author)
- Swedish University of Agricultural Sciences,Sveriges lantbruksuniversitet,Institutionen för anatomi, fysiologi och biokemi,Department of Anatomy, Physiology and Biochemistry (AFB),Swedish Univ Agr Sci, Dept Anat Physiol & Biochem, S-75007 Uppsala, Sweden.
-
- Andersson, Göran (author)
- Swedish University of Agricultural Sciences,Sveriges lantbruksuniversitet,Institutionen för husdjursgenetik (HGEN),Department of Animal Breeding and Genetics,Swedish Univ Agr Sci, Dept Anim Breeding & Genet, S-75007 Uppsala, Sweden.
-
- Lindblad-Toh, Kerstin (author)
- Uppsala universitet,Institutionen för medicinsk biokemi och mikrobiologi,Broad Inst Harvard & MIT, Cambridge, MA 02142 USA.
-
- Yeo, Giles S. H. (author)
- Univ Cambridge, WT MRC Inst Metab Sci, Metab Res Labs, Cambridge CB2 0QQ, England.
-
- O'Rahilly, Stephen (author)
- Univ Cambridge, WT MRC Inst Metab Sci, Metab Res Labs, Cambridge CB2 0QQ, England.
-
show less...
-
Univ Cambridge, WT MRC Inst Metab Sci, Metab Res Labs, Cambridge CB2 0QQ, England Univ Cambridge, WT MRC Inst Metab Sci, MRC Epidemiol Unit, Cambridge CB2 0QQ, England. (creator_code:org_t)
-
- Elsevier BV, 2016
- 2016
- English.
-
In: Cell Metabolism. - : Elsevier BV. - 1550-4131 .- 1932-7420. ; 23:5, s. 893-900
- Related links:
-
https://uu.diva-port... (primary) (Raw object)
-
show more...
-
http://www.cell.com/...
-
https://urn.kb.se/re...
-
https://doi.org/10.1...
-
https://res.slu.se/i...
-
show less...
Abstract
Subject headings
Close
- Sequencing of candidate genes for obesity in Labrador retriever dogs identified a 14 bp deletion in pro-opiomelanocortin (POMC) with an allele frequency of 12%. The deletion disrupts the b-MSH and beta-endorphin coding sequences and is associated with body weight (per allele effect of 0.33 SD), adiposity, and greater food motivation. Among other dog breeds, the deletion was only found in the closely related flat-coat retriever (FCR), where it is similarly associated with body weight and food motivation. The mutation is significantly more common in Labrador retrievers selected to become assistance dogs than pets. In conclusion, the deletion in POMC is a significant modifier of weight and appetite in Labrador retrievers and FCRs and may influence other behavioral traits.
Subject headings
- MEDICIN OCH HÄLSOVETENSKAP -- Klinisk medicin -- Endokrinologi och diabetes (hsv//swe)
- MEDICAL AND HEALTH SCIENCES -- Clinical Medicine -- Endocrinology and Diabetes (hsv//eng)
- MEDICIN OCH HÄLSOVETENSKAP -- Medicinska och farmaceutiska grundvetenskaper -- Cell- och molekylärbiologi (hsv//swe)
- MEDICAL AND HEALTH SCIENCES -- Basic Medicine -- Cell and Molecular Biology (hsv//eng)
- LANTBRUKSVETENSKAPER -- Bioteknologi med applikationer på växter och djur -- Genetik och förädling inom lantbruksvetenskap (hsv//swe)
- AGRICULTURAL SCIENCES -- Agricultural Biotechnology -- Genetics and Breeding in Agricultural Sciences (hsv//eng)
- LANTBRUKSVETENSKAPER -- Husdjursvetenskap -- Husdjursvetenskap (hsv//swe)
- AGRICULTURAL SCIENCES -- Animal and Dairy Sience -- Animal and Dairy Science. (hsv//eng)
Publication and Content Type
- ref (subject category)
- art (subject category)
Find in a library
To the university's database
- By the author/editor
-
Raffan, Eleanor
-
Dennis, Rowena J ...
-
O'Donovan, Conor ...
-
Becker, Julia M.
-
Scott, Robert A.
-
Smith, Stephen P ...
-
show more...
-
Withers, David J ...
-
Wood, Claire J.
-
Conci, Elena
-
Clements, Dylan ...
-
Summers, Kim M.
-
German, Alexande ...
-
Mellersh, Cathry ...
-
Arendt, Maja L.
-
Iyemere, Valenti ...
-
Withers, Elaine
-
Söder, Josefin
-
Wernersson, Sara
-
Andersson, Göran
-
Lindblad-Toh, Ke ...
-
Yeo, Giles S. H.
-
O'Rahilly, Steph ...
-
show less...
- About the subject
-
- MEDICAL AND HEALTH SCIENCES
-
MEDICAL AND HEAL ...
-
and Clinical Medicin ...
-
and Endocrinology an ...
-
- MEDICAL AND HEALTH SCIENCES
-
MEDICAL AND HEAL ...
-
and Basic Medicine
-
and Cell and Molecul ...
-
- AGRICULTURAL SCIENCES
-
AGRICULTURAL SCI ...
-
and Agricultural Bio ...
-
and Genetics and Bre ...
-
- AGRICULTURAL SCIENCES
-
AGRICULTURAL SCI ...
-
and Animal and Dairy ...
-
and Animal and Dairy ...
- Articles in the publication
-
Cell Metabolism
- By the university
-
Uppsala University
-
Swedish University of Agricultural Sciences