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Bone morphogenetic ...
Bone morphogenetic proteins but not growth differentiation factors induce dopaminergic differentiation in mesencephalic precursors.
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- Brederlau, Anke, 1968 (författare)
- Gothenburg University,Göteborgs universitet,Institutionen för anatomi och cellbiologi,Institute of Anatomy and Cell Biology
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- Faigle, Roland, 1977 (författare)
- Gothenburg University,Göteborgs universitet,Institutionen för anatomi och cellbiologi,Institute of Anatomy and Cell Biology
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Kaplan, P (författare)
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visa fler...
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Odin, P (författare)
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- Funa, Keiko, 1949 (författare)
- Gothenburg University,Göteborgs universitet,Institutionen för anatomi och cellbiologi,Institute of Anatomy and Cell Biology
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visa färre...
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(creator_code:org_t)
- 2002
- 2002
- Engelska.
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Ingår i: Molecular and cellular neurosciences. - 1044-7431. ; 21:3, s. 367-78
- Relaterad länk:
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https://gup.ub.gu.se...
Abstract
Ämnesord
Stäng
- Bone morphogenetic proteins (BMPs) and growth differentiation factors (GDFs) are potential therapeutic molecules for the treatment of Parkinson's disease (PO). Here we compare the effects of BMP3, 5, 6, and 7 and GDF5 and 6 in a rat mesencephalic cell culture system that reflects the developmental stage of neurons around birth. High concentrations of BMP5, 6, and 7 and GDF5 and 6 induced astroglial cell fate and a depletion of oligodendrocytes. Only BMP5, 6, and 7, however, significantly increased the number of tyrosine hydroxylase (TH)-positive neurons and induced nuclear translocation of the phosphorylated BMP-restricted Smad in a substantial number of TH- and microtubule-associated protein 2(MAP2ab)-positive cells. None of the proteins protected TH-positive cells against 6-hydroxydopamine-induced oxidative stress. BMP3 was without any effect throughout the studies. We conclude that BMP5, 6, and 7 act directly and independently on precursors of the dopaminergic and astroglial lineage and induce their differentiation. In contrast, GDF5 and 6 primarily affect nonneuronal cells in mesencephalic cultures of this stage.
Ämnesord
- MEDICIN OCH HÄLSOVETENSKAP -- Medicinska och farmaceutiska grundvetenskaper (hsv//swe)
- MEDICAL AND HEALTH SCIENCES -- Basic Medicine (hsv//eng)
Nyckelord
- Animals
- Bone Morphogenetic Proteins
- pharmacology
- therapeutic use
- Brain Tissue Transplantation
- Cell Differentiation
- drug effects
- physiology
- Cell Survival
- drug effects
- physiology
- Cells
- Cultured
- Dopamine
- metabolism
- Dose-Response Relationship
- Drug
- Fetus
- Graft Survival
- drug effects
- physiology
- Growth Substances
- pharmacology
- therapeutic use
- Neurons
- cytology
- drug effects
- metabolism
- Neuroprotective Agents
- pharmacology
- Oligodendroglia
- cytology
- drug effects
- metabolism
- Oxidopamine
- pharmacology
- Parkinson Disease
- therapy
- Rats
- Rats
- Sprague-Dawley
- Stem Cells
- cytology
- drug effects
- metabolism
- Substantia Nigra
- cytology
- drug effects
- embryology
- Tyrosine 3-Monooxygenase
- metabolism
Publikations- och innehållstyp
- ref (ämneskategori)
- art (ämneskategori)
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