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Ethanol prevents de...
Ethanol prevents development of destructive arthritis
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- Jonsson, Ing-Marie, 1949 (author)
- Gothenburg University,Göteborgs universitet,Institutionen för medicin, avdelningen för reumatologi och inflammationsforskning,Institute of Medicine, Department of Rheumatology and Inflammation Research,Göteborg University, Göteborg, Sweden
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- Verdrengh, Margareta, 1942 (author)
- Gothenburg University,Göteborgs universitet,Institutionen för medicin, avdelningen för reumatologi och inflammationsforskning,Institute of Medicine, Department of Rheumatology and Inflammation Research,Göteborg University, Göteborg, Sweden
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- Brisslert, Mikael, 1974 (author)
- Gothenburg University,Göteborgs universitet,Institutionen för medicin, avdelningen för reumatologi och inflammationsforskning,Institute of Medicine, Department of Rheumatology and Inflammation Research,Göteborg University, Göteborg, Sweden
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- Silfverswärd Lindblad, Sofia, 1980 (author)
- Gothenburg University,Göteborgs universitet,Institutionen för medicin, avdelningen för reumatologi och inflammationsforskning,Institute of Medicine, Department of Rheumatology and Inflammation Research,Göteborg University, Göteborg, Sweden
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- Bokarewa, Maria, 1963 (author)
- Gothenburg University,Göteborgs universitet,Institutionen för medicin, avdelningen för reumatologi och inflammationsforskning,Institute of Medicine, Department of Rheumatology and Inflammation Research,Göteborg University, Göteborg, Sweden
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- Islander, Ulrika, 1975 (author)
- Gothenburg University,Göteborgs universitet,Institutionen för medicin, avdelningen för reumatologi och inflammationsforskning,Institute of Medicine, Department of Rheumatology and Inflammation Research,Göteborg University, Göteborg, Sweden
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- Carlsten, Hans, 1954 (author)
- Gothenburg University,Göteborgs universitet,Institutionen för medicin, avdelningen för reumatologi och inflammationsforskning,Institute of Medicine, Department of Rheumatology and Inflammation Research,Göteborg University, Göteborg, Sweden
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- Ohlsson, Claes, 1965 (author)
- Gothenburg University,Göteborgs universitet,Institutionen för medicin, avdelningen för invärtesmedicin,Institute of Medicine, Department of Internal Medicine,Göteborg University, Göteborg, Sweden
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- Nandakumar, Kutty Selva, 1965- (author)
- Lund University, Lund, Sweden
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- Holmdahl, Rikard (author)
- Lund University,Lunds universitet,Immunologi,Forskargrupper vid Lunds universitet,Immunology,Lund University Research Groups,Lund University, Lund, Sweden
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- Tarkowski, Andrej, 1951 (author)
- Gothenburg University,Göteborgs universitet,Institutionen för medicin, avdelningen för reumatologi och inflammationsforskning,Institute of Medicine, Department of Rheumatology and Inflammation Research,Göteborg University, Göteborg, Sweden; Department of Rheumatology and Inflammation Research, Göteborg, Sweden
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(creator_code:org_t)
- 2007-01-02
- 2007
- English.
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In: Proc Natl Acad Sci U S A. - Washington, DC : Proceedings of the National Academy of Sciences. - 0027-8424 .- 1091-6490. ; 104:1, s. 258-63
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http://dx.doi.org/10... (free)
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https://doi.org/10.1...
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https://doi.org/10.1...
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Abstract
Subject headings
Close
- Environmental factors are thought to play a major role in the development of rheumatoid arthritis. Because the use of ethanol is widespread, we assessed the role of ethanol intake on the propensity to develop chronic arthritis. Collagen type II-immunized mice were given water or water containing 10% (vol/vol) ethanol or its metabolite acetaldehyde. Their development of arthritis was assessed, as well as the impact of ethanol on leukocyte migration and activation of intracellular transcription factors. Mice exposed daily to this dose of ethanol did not display any liver toxicity, and the development of erosive arthritis was almost totally abrogated. In contrast, the antibody-mediated effector phase of collagen-induced arthritis was not influenced by ethanol exposure. Also, the major ethanol metabolite, acetaldehyde, prevented the development of arthritis. This antiinflammatory and antidestructive property of ethanol was mediated by (i) down-regulation of leukocyte migration and (ii) up-regulation of testosterone secretion, with the latter leading to decreased NF-kappaB activation. We conclude that low but persistent ethanol consumption delays the onset and halts the progression of collagen-induced arthritis by interaction with innate immune responsiveness.
Subject headings
- MEDICIN OCH HÄLSOVETENSKAP -- Klinisk medicin -- Reumatologi och inflammation (hsv//swe)
- MEDICAL AND HEALTH SCIENCES -- Clinical Medicine -- Rheumatology and Autoimmunity (hsv//eng)
- MEDICIN OCH HÄLSOVETENSKAP -- Medicinska och farmaceutiska grundvetenskaper -- Immunologi inom det medicinska området (hsv//swe)
- MEDICAL AND HEALTH SCIENCES -- Basic Medicine -- Immunology in the medical area (hsv//eng)
Keyword
- Animals
- Arthritis
- Experimental/immunology/*prevention & control
- Bone Density/drug effects
- Cell Movement/drug effects
- Collagen Type II/immunology
- Ethanol/*pharmacology
- Immunity
- Natural/drug effects
- Interleukin-10/blood
- Interleukin-6/blood
- Leukocytes/drug effects/physiology
- Male
- Mice
- Mice
- Inbred DBA
- NF-kappa B/physiology
- Testosterone/biosynthesis
- Transcription Factor AP-1/physiology
- antibodies
- sex hormones
- inflammation
- cytokines
- immunity
- inflammation
Publication and Content Type
- ref (subject category)
- art (subject category)
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Jonsson, Ing-Mar ...
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Verdrengh, Marga ...
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Brisslert, Mikae ...
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Silfverswärd Lin ...
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Bokarewa, Maria, ...
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Islander, Ulrika ...
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Carlsten, Hans, ...
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Ohlsson, Claes, ...
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Nandakumar, Kutt ...
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Holmdahl, Rikard
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Tarkowski, Andre ...
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MEDICAL AND HEAL ...
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University of Gothenburg
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Halmstad University