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RNA Polymerase III ...
RNA Polymerase III as a Gatekeeper to Prevent Severe VZV Infections
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Carter-Timofte, M. E. (författare)
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- Paludan, Sören R, 1972 (författare)
- Gothenburg University,Göteborgs universitet,Institutionen för kliniska vetenskaper,Institute of Clinical Sciences
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Mogensen, T. H. (författare)
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(creator_code:org_t)
- Elsevier BV, 2018
- 2018
- Engelska.
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Ingår i: Trends in Molecular Medicine. - : Elsevier BV. - 1471-4914. ; 24:10, s. 904-915
- Relaterad länk:
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https://gup.ub.gu.se...
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visa fler...
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https://doi.org/10.1...
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Abstract
Ämnesord
Stäng
- In most individuals, varicella zoster virus (VZV) causes varicella upon primary infection and zoster during reactivation. However, in a subset of individuals, VZV may cause severe disease, including encephalitis. Host genetics is believed to be the main determinant of exacerbated disease manifestations. Recent studies have demonstrated that defects in the DNA sensor RNA polymerase III (POL III) confer selective increased susceptibility to VZV infection, thus providing fundamental new insight into VZV immunity. Here we describe the roles of POL III in housekeeping and immune surveillance during VZV infection. We present the latest knowledge on the role of POL III in VZV infection and discuss outstanding questions related to the role of POL III in VZV immunity, and how this insight can be translated into clinical medicine.
Ämnesord
- MEDICIN OCH HÄLSOVETENSKAP -- Medicinska och farmaceutiska grundvetenskaper -- Cell- och molekylärbiologi (hsv//swe)
- MEDICAL AND HEALTH SCIENCES -- Basic Medicine -- Cell and Molecular Biology (hsv//eng)
Nyckelord
- varicella-zoster-virus
- herpes-zoster
- rig-i
- transcription initiation
- signaling pathway
- mediated-immunity
- viral-infections
- united-states
- cytosolic DNA
- risk-factors
- Biochemistry & Molecular Biology
- Cell Biology
- Research & Experimental
- Medicine
Publikations- och innehållstyp
- ref (ämneskategori)
- art (ämneskategori)
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