Fibroblast Growth Factor-23 and Risk of Cardiovascular Diseases A Mendelian Randomization Study

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Fibroblast Growth Factor-23 and Risk of Cardiovascular Diseases A Mendelian Randomization Study

Donovan, Killian (author): Univ Oxford, Nuffield Dept Populat Hlth NDPH, Clin Trial Serv Unit, Oxford, England.;Univ Oxford, Nuffield Dept Populat Hlth NDPH, Epidemiol Studies Unit, Oxford, England.

Herrington, William G. (author): Univ Oxford, Nuffield Dept Populat Hlth NDPH, Clin Trial Serv Unit, Oxford, England.;Univ Oxford, Nuffield Dept Populat Hlth NDPH, Epidemiol Studies Unit, Oxford, England.;Univ Oxford, NDPH, Med Res Council Populat Hlth Res Unit, Oxford, England.;Churchill Hosp, Oxford Kidney Unit, Oxford, England.

Pare, Guillaume (author): McMaster Univ, Populat Hlth Res Inst, Hamilton, ON, Canada.

Pigeyre, Marie (author): McMaster Univ, Populat Hlth Res Inst, Hamilton, ON, Canada.

Haynes, Richard (author): Univ Oxford, Nuffield Dept Populat Hlth NDPH, Clin Trial Serv Unit, Oxford, England.;Univ Oxford, Nuffield Dept Populat Hlth NDPH, Epidemiol Studies Unit, Oxford, England.;Univ Oxford, NDPH, Med Res Council Populat Hlth Res Unit, Oxford, England.;Churchill Hosp, Oxford Kidney Unit, Oxford, England.

Sardell, Rebecca (author): Univ Oxford, Nuffield Dept Populat Hlth NDPH, Clin Trial Serv Unit, Oxford, England.;Univ Oxford, Nuffield Dept Populat Hlth NDPH, Epidemiol Studies Unit, Oxford, England.

Butterworth, Adam S. (author): Univ Cambridge, Dept Publ Hlth & Primary Care, BHF Cardiovasc Epidemiol Unit, Cambridge, England.

Folkersen, Lasse (author): Danish Natl Genome Ctr, Copenhagen, Denmark.

Gustafsson, Stefan (author): Uppsala universitet,Science for Life Laboratory, SciLifeLab,Molekylär epidemiologi

Wang, Qin (author): Baker Heart & Diabet Inst, Syst Epidemiol, Melbourne, Vic, Australia.

Baigent, Colin (author): Univ Oxford, Nuffield Dept Populat Hlth NDPH, Clin Trial Serv Unit, Oxford, England.;Univ Oxford, Nuffield Dept Populat Hlth NDPH, Epidemiol Studies Unit, Oxford, England.;Univ Oxford, NDPH, Med Res Council Populat Hlth Res Unit, Oxford, England.

Malarstig, Anders (author): Karolinska Inst, Dept Med Epidemiol & Biostat, Solna, Sweden.

Holmes, Michael V. (author): Univ Oxford, Nuffield Dept Populat Hlth NDPH, Clin Trial Serv Unit, Oxford, England.;Univ Oxford, Nuffield Dept Populat Hlth NDPH, Epidemiol Studies Unit, Oxford, England.;Univ Oxford, NDPH, Med Res Council Populat Hlth Res Unit, Oxford, England.;Univ Oxford, Big Data Inst, Li Ka Shing Ctr Hlth Informat & Discovery, Oxford, England.

Staplin, Natalie (author): Univ Oxford, Nuffield Dept Populat Hlth NDPH, Clin Trial Serv Unit, Oxford, England.;Univ Oxford, Nuffield Dept Populat Hlth NDPH, Epidemiol Studies Unit, Oxford, England.;Univ Oxford, NDPH, Med Res Council Populat Hlth Res Unit, Oxford, England.;Univ Oxford, Big Data Inst, Li Ka Shing Ctr Hlth Informat & Discovery, Oxford, England.

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Univ Oxford, Nuffield Dept Populat Hlth NDPH, Clin Trial Serv Unit, Oxford, England;Univ Oxford, Nuffield Dept Populat Hlth NDPH, Epidemiol Studies Unit, Oxford, England. Univ Oxford, Nuffield Dept Populat Hlth NDPH, Clin Trial Serv Unit, Oxford, England.;Univ Oxford, Nuffield Dept Populat Hlth NDPH, Epidemiol Studies Unit, Oxford, England.;Univ Oxford, NDPH, Med Res Council Populat Hlth Res Unit, Oxford, England.;Churchill Hosp, Oxford Kidney Unit, Oxford, England. (creator_code:org_t)

Wolters Kluwer, 2023
2023
English.
In: American Society of Nephrology. Clinical Journal. - : Wolters Kluwer. - 1555-9041 .- 1555-905X. ; 18:1, s. 17-27

Related links:: https://doi.org/10.2...; show more...; https://uu.diva-port... (primary) (Raw object); https://urn.kb.se/re...; https://doi.org/10.2...; http://kipublication...; show less...

Journal article (peer-reviewed)

Abstract Subject headings

Background Fibroblast growth factor-23 (FGF-23) is associated with a range of cardiovascular and noncardiovascular diseases in conventional epidemiological studies, but substantial residual confounding may exist. Mendelian randomization approaches can help control for such confounding.Methods SCALLOP Consortium data of 19,195 participants were used to generate an FGF-23 genetic score. Data from 337,448 UK Biobank participants were used to estimate associations between higher genetically predicted FGF-23 concentration and the odds of any atherosclerotic cardiovascular disease (n=26,266 events), nonatherosclerotic cardiovascular disease (n=12,652), and noncardiovascular diseases previously linked to FGF-23. Measurements of carotid intima-media thickness and left ventricular mass were available in a subset. Associations with cardiovascular outcomes were also tested in three large case-control consortia: CARDIOGRAMplusC4D (coronary artery disease, n=181,249 cases), MEGASTROKE (stroke, n=34,217), and HERMES (heart failure, n=47,309).Results We identified 34 independent variants for circulating FGF-23, which formed a validated genetic score. There were no associations between genetically predicted FGF-23 and any of the cardiovascular or non cardiovascular outcomes. In UK Biobank, the odds ratio (OR) for any atherosclerotic cardiovascular disease per 1-SD higher genetically predicted logFGF-23 was 1.03 (95% confidence interval [95% CI], 0.98 to 1.08), and for any nonatherosclerotic cardiovascular disease, it was 1.01 (95% CI, 0.94 to 1.09). The ORs in the case-control consortia were 1.00 (95% CI, 0.97 to 1.03) for coronary artery disease, 1.01 (95% CI, 0.95 to 1.07) for stroke, and 1.00 (95% CI, 0.95 to 1.05) for heart failure. In those with imaging, logFGF-23 was not associated with carotid or cardiac abnormalities.Conclusions Genetically predicted FGF-23 levels are not associated with atherosclerotic and nonatherosclerotic cardiovascular diseases, suggesting no important causal link.

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By the author/editor: Donovan, Killian; Herrington, Will ...; Pare, Guillaume; Pigeyre, Marie; Haynes, Richard; Sardell, Rebecca; show more...; Butterworth, Ada ...; Folkersen, Lasse; Gustafsson, Stef ...; Wang, Qin; Baigent, Colin; Malarstig, Ander ...; Holmes, Michael ...; Staplin, Natalie; show less...

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MEDICAL AND HEALTH SCIENCES: MEDICAL AND HEAL ...; and Clinical Medicin ...; and Cardiac and Card ...

Articles in the publication: American Society ...

By the university: Uppsala University; Karolinska Institutet

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Fibroblast Growth Factor-23 and Risk of Cardiovascular Diseases A Mendelian Randomization Study

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