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Sökning: onr:"swepub:oai:DiVA.org:uu-409789" > Amount and Intensit...

Amount and Intensity of Leisure-Time Physical Activity and Lower Cancer Risk

Matthews, Charles E. (författare)
NCI, Div Canc Epidemiol & Genet, Metab Epidemiol Branch, Bethesda, MD 20892 USA
Moore, Steven C. (författare)
NCI, Div Canc Epidemiol & Genet, Metab Epidemiol Branch, Bethesda, MD 20892 USA
Arem, Hannah (författare)
George Washington Univ, Sch Publ Hlth, Dept Epidemiol, Washington, DC USA
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Cook, Michael B. (författare)
NCI, Div Canc Epidemiol & Genet, Metab Epidemiol Branch, Bethesda, MD 20892 USA
Trabert, Britton (författare)
NCI, Div Canc Epidemiol & Genet, Metab Epidemiol Branch, Bethesda, MD 20892 USA
Håkansson, Niclas (författare)
Karolinska Institutet
Larsson, Susanna C. (författare)
Karolinska Institutet,Uppsala universitet,Ortopedi,Karolinska Inst, Inst Environm Med, Unit Cardiovasc & Nutr Epidemiol, Stockholm, Sweden
Wolk, Alicja (författare)
Karolinska Institutet,Uppsala universitet,Ortopedi,Karolinska Inst, Inst Environm Med, Unit Cardiovasc & Nutr Epidemiol, Stockholm, Sweden
Gapstur, Susan M. (författare)
Amer Canc Soc, Behav & Epidemiol Res, Atlanta, GA 30329 USA
Lynch, Brigid M. (författare)
Canc Council Victoria, Canc Epidemiol Div, Melbourne, Vic, Australia;Univ Melbourne, Ctr Epidemiol & Biostat, Sch Populat & Global Hlth, Melbourne, Vic, Australia;Baker Heart & Diabet Inst, Phys Act Lab, Melbourne, Vic, Australia
Milne, Roger L. (författare)
Canc Council Victoria, Canc Epidemiol Div, Melbourne, Vic, Australia;Univ Melbourne, Ctr Epidemiol & Biostat, Sch Populat & Global Hlth, Melbourne, Vic, Australia;Monash Univ, Sch Clin Sci, Precis Med, Monash Hlth, Melbourne, Vic, Australia
Freedman, Neal D. (författare)
NCI, Div Canc Epidemiol & Genet, Metab Epidemiol Branch, Bethesda, MD 20892 USA
Huang, Wen-Yi (författare)
NCI, Div Canc Epidemiol & Genet, Metab Epidemiol Branch, Bethesda, MD 20892 USA
de Gonzalez, Amy Berrington (författare)
NCI, Div Canc Epidemiol & Genet, Radiat Epidemiol Branch, Bethesda, MD 20892 USA
Kitahara, Cari M. (författare)
NCI, Div Canc Epidemiol & Genet, Radiat Epidemiol Branch, Bethesda, MD 20892 USA
Linet, Martha S. (författare)
Karolinska Institutet
Shiroma, Eric J. (författare)
NIA, Lab Epidemiol & Populat Sci, Baltimore, MD 21224 USA
Sandin, Sven (författare)
Karolinska Inst, Dept Med Epidemiol & Biostat, Stockholm, Sweden;Icahn Sch Med Mt Sinai, Dept Psychiat, New York, NY 10029 USA;Seaver Autism Ctr Res & Treatment Mt Sinai, New York, NY USA
Patel, Alpa, V (författare)
Amer Canc Soc, Behav & Epidemiol Res, Atlanta, GA 30329 USA
Lee, I-Min (författare)
Brigham & Womens Hosp, 75 Francis St, Boston, MA 02115 USA;Harvard Med Sch, Harvard TH Chan Sch Publ Hlth, Boston, MA 02115 USA
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 (creator_code:org_t)
AMER SOC CLINICAL ONCOLOGY, 2020
2020
Engelska.
Ingår i: Journal of Clinical Oncology. - : AMER SOC CLINICAL ONCOLOGY. - 0732-183X .- 1527-7755. ; 38:7, s. 686-697
Relaterad länk:
https://doi.org/10.1...
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https://uu.diva-port... (primary) (Raw object)
https://urn.kb.se/re...
https://doi.org/10.1...
http://kipublication...
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  • Tidskriftsartikel (refereegranskat)
Abstract Ämnesord
Stäng  
  • PURPOSE: To determine whether recommended amounts of leisure-time physical activity (ie, 7.5-15 metabolic equivalent task [MET] hours/week) are associated with lower cancer risk, describe the shape of the dose-response relationship, and explore associations with moderate- and vigorous-intensity physical activity.METHODS: Data from 9 prospective cohorts with self-reported leisure-time physical activity and follow-up for cancer incidence were pooled. Multivariable Cox regression was used to estimate adjusted hazard ratios (HRs) and 95% CIs of the relationships between physical activity with incidence of 15 types of cancer. Dose-response relationships were modeled with restricted cubic spline functions that compared 7.5, 15.0, 22.5, and 30.0 MET hours/week to no leisure-time physical activity, and statistically significant associations were determined using tests for trend (P < .05) and 95% CIs (< 1.0).RESULTS: A total of 755,459 participants (median age, 62 years [range, 32-91 years]; 53% female) were followed for 10.1 years, and 50,620 incident cancers accrued. Engagement in recommended amounts of activity (7.5-15 MET hours/week) was associated with a statistically significant lower risk of 7 of the 15 cancer types studied, including colon (8%-14% lower risk in men), breast (6%-10% lower risk), endometrial (10%-18% lower risk), kidney (11%-17% lower risk), myeloma (14%-19% lower risk), liver (18%-27% lower risk), and non-Hodgkin lymphoma (11%-18% lower risk in women). The dose response was linear in shape for half of the associations and nonlinear for the others. Results for moderate- and vigorous-intensity leisure-time physical activity were mixed. Adjustment for body mass index eliminated the association with endometrial cancer but had limited effect on other cancer types.CONCLUSION: Health care providers, fitness professionals, and public health practitioners should encourage adults to adopt and maintain physical activity at recommended levels to lower risks of multiple cancers. 

Ämnesord

MEDICIN OCH HÄLSOVETENSKAP  -- Klinisk medicin -- Cancer och onkologi (hsv//swe)
MEDICAL AND HEALTH SCIENCES  -- Clinical Medicine -- Cancer and Oncology (hsv//eng)

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