Microbiome and metabolome features of the cardiometabolic disease spectrum

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Microbiome and metabolome features of the cardiometabolic disease spectrum

Fromentin, S. (author): Université Paris-Saclay,University Paris-Saclay

Forslund, S. K. (author): European Molecular Biology Laboratory,Charité Universitätsmedizin Berlin,Charité University Medicine Berlin,Max Delbrueck Centrum Fuer Molekulare Medizin,The Max Delbrück Center for Molecular Medicine

Chechi, K. (author): St Mary's Hospital

Aron-Wisnewsky, J. (author): Sorbonne Université,Sorbonne University,Assistance publique – Hôpitaux de Paris (AP-HP)

Chakaroun, R. (author): Universität Leipzig,Leipzig University

Nielsen, T. (author): Köpenhamns universitet,University of Copenhagen

Tremaroli, Valentina, 1978 (author): Gothenburg University,Göteborgs universitet,Institutionen för medicin, avdelningen för molekylär och klinisk medicin,Wallenberglaboratoriet,Institute of Medicine, Department of Molecular and Clinical Medicine,Wallenberg Laboratory

Ji, Boyang, 1983 (author): Chalmers tekniska högskola,Chalmers University of Technology

Prifti, E. (author): Sorbonne Université,Sorbonne University,UMMISCO

Myridakis, A. (author)

Chilloux, J. (author)

Andrikopoulos, P. (author)

Fan, Y. (author): Köpenhamns universitet,University of Copenhagen

Olanipekun, M. T. (author)

Alves, R. (author): European Molecular Biology Laboratory

Adiouch, S. (author): Sorbonne Université,Sorbonne University

Nielsen, Jens B, 1962 (author): Weizmann Institute of Science,Köpenhamns universitet,University of Copenhagen,Chalmers tekniska högskola,Chalmers University of Technology

Talmor-Barkan, Y. (author): Weizmann Institute of Science

Belda, E. (author): Assistance publique – Hôpitaux de Paris (AP-HP),Sorbonne Université,Sorbonne University

Caesar, Robert, 1973 (author): Gothenburg University,Göteborgs universitet,Institutionen för medicin, avdelningen för molekylär och klinisk medicin,Wallenberglaboratoriet,Institute of Medicine, Department of Molecular and Clinical Medicine,Wallenberg Laboratory

Li, Peishun, 1988 (author): European Molecular Biology Laboratory,Chalmers tekniska högskola,Chalmers University of Technology

Falony, G. (author): Flanders Interuniversity Institute for Biotechnology,Katholieke Universiteit Leuven

Fellahi, S. (author)

Galan, P. (author): Université Paris-Saclay,University Paris-Saclay

Galleron, N. (author): Université Paris-Saclay,University Paris-Saclay

Helft, G. (author): Assistance publique – Hôpitaux de Paris (AP-HP)

Hoyles, L. (author): Nottingham Trent University

Isnard, R. (author): Assistance publique – Hôpitaux de Paris (AP-HP)

Le Chatelier, E. (author): Université Paris-Saclay,University Paris-Saclay

Julienne, H. (author): Université Paris-Saclay,University Paris-Saclay

Olsson, Lisa M., 1984 (author): Gothenburg University,Göteborgs universitet,Institutionen för medicin, avdelningen för molekylär och klinisk medicin,Wallenberglaboratoriet,Institute of Medicine, Department of Molecular and Clinical Medicine,Wallenberg Laboratory

Pedersen, H. K. (author): Köpenhamns universitet,University of Copenhagen

Pons, N. (author): Université Paris-Saclay,University Paris-Saclay

Quinquis, B. (author): Université Paris-Saclay,University Paris-Saclay

Rouault, C. (author): Sorbonne Université,Sorbonne University

Roume, H. (author): Université Paris-Saclay,University Paris-Saclay

Salem, J. E. (author): Sorbonne Université,Sorbonne University

Schmidt, T. S. B. (author): European Molecular Biology Laboratory

Vieira-Silva, S. (author): Katholieke Universiteit Leuven,Flanders Interuniversity Institute for Biotechnology

Li, P. S. (author)

Zimmermann-Kogadeeva, M. (author): European Molecular Biology Laboratory

Lewinter, C. (author): Köpenhamns universitet,University of Copenhagen

Sondertoft, N. B. (author)

Hansen, T. H. (author): Köpenhamns universitet,University of Copenhagen

Gauguier, D. (author)

Gotze, J. P. (author): Köpenhamns universitet,University of Copenhagen

Kober, L. (author): Köpenhamns universitet,University of Copenhagen

Kornowski, R. (author)

Vestergaard, H. (author): Köpenhamns universitet,University of Copenhagen

Hansen, T. (author)

Zucker, J. D. (author): UMMISCO,Sorbonne Université,Sorbonne University

Hercberg, S. (author)

Letunic, I. (author): Biobyte Solutions GmbH

Bäckhed, Fredrik, 1973 (author): Gothenburg University,Göteborgs universitet,Institutionen för medicin, avdelningen för molekylär och klinisk medicin,Wallenberglaboratoriet,Institute of Medicine, Department of Molecular and Clinical Medicine,Wallenberg Laboratory,Köpenhamns universitet,University of Copenhagen

Oppert, J. M. (author): Assistance publique – Hôpitaux de Paris (AP-HP)

Nielsen, J. (author)

Raes, J. (author): Flanders Interuniversity Institute for Biotechnology,Katholieke Universiteit Leuven

Bork, P. (author): European Molecular Biology Laboratory,Köpenhamns universitet,University of Copenhagen

Stumvoll, M. (author): Universität Leipzig,Leipzig University

Segal, E. (author): Weizmann Institute of Science

Clement, K. (author): Sorbonne Université,Sorbonne University,Assistance publique – Hôpitaux de Paris (AP-HP)

Dumas, M. E. (author)

Ehrlich, S. D. (author): Université Paris-Saclay,University Paris-Saclay,University College London (UCL)

Pedersen, O. (author)

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2022-02-17
2022
English.
In: Nature Medicine. - : Springer Science and Business Media LLC. - 1078-8956 .- 1546-170X. ; 28:2

Related links:: https://www.nature.c...; show more...; https://research.cha... (primary) (free); https://gup.ub.gu.se...; https://doi.org/10.1...; https://research.cha...; show less...

Journal article (peer-reviewed)

Abstract Subject headings

By studying individuals along a spectrum of cardiometabolic disease and adjusting for effects of lifestyle and medication, this investigation identifies alterations of the metabolome and microbiome from dysmetabolic conditions, such as obesity and type 2 diabetes, to ischemic heart disease. Previous microbiome and metabolome analyses exploring non-communicable diseases have paid scant attention to major confounders of study outcomes, such as common, pre-morbid and co-morbid conditions, or polypharmacy. Here, in the context of ischemic heart disease (IHD), we used a study design that recapitulates disease initiation, escalation and response to treatment over time, mirroring a longitudinal study that would otherwise be difficult to perform given the protracted nature of IHD pathogenesis. We recruited 1,241 middle-aged Europeans, including healthy individuals, individuals with dysmetabolic morbidities (obesity and type 2 diabetes) but lacking overt IHD diagnosis and individuals with IHD at three distinct clinical stages-acute coronary syndrome, chronic IHD and IHD with heart failure-and characterized their phenome, gut metagenome and serum and urine metabolome. We found that about 75% of microbiome and metabolome features that distinguish individuals with IHD from healthy individuals after adjustment for effects of medication and lifestyle are present in individuals exhibiting dysmetabolism, suggesting that major alterations of the gut microbiome and metabolome might begin long before clinical onset of IHD. We further categorized microbiome and metabolome signatures related to prodromal dysmetabolism, specific to IHD in general or to each of its three subtypes or related to escalation or de-escalation of IHD. Discriminant analysis based on specific IHD microbiome and metabolome features could better differentiate individuals with IHD from healthy individuals or metabolically matched individuals as compared to the conventional risk markers, pointing to a pathophysiological relevance of these features.

Subject headings

MEDICIN OCH HÄLSOVETENSKAP -- Klinisk medicin -- Kardiologi (hsv//swe)
MEDICAL AND HEALTH SCIENCES -- Clinical Medicine -- Cardiac and Cardiovascular Systems (hsv//eng)
MEDICIN OCH HÄLSOVETENSKAP -- Klinisk medicin -- Endokrinologi och diabetes (hsv//swe)
MEDICAL AND HEALTH SCIENCES -- Clinical Medicine -- Endocrinology and Diabetes (hsv//eng)
MEDICIN OCH HÄLSOVETENSKAP -- Klinisk medicin -- Annan klinisk medicin (hsv//swe)
MEDICAL AND HEALTH SCIENCES -- Clinical Medicine -- Other Clinical Medicine (hsv//eng)
MEDICIN OCH HÄLSOVETENSKAP -- Medicinsk bioteknologi -- Biomedicinsk laboratorievetenskap/teknologi (hsv//swe)
MEDICAL AND HEALTH SCIENCES -- Medical Biotechnology -- Biomedical Laboratory Science/Technology (hsv//eng)

Keyword

coronary-artery-disease
gut microbiota
p-cresol
heart
risk
impact
serum
signatures
plasma
health
Biochemistry & Molecular Biology
Cell Biology
Research & Experimental
Medicine

Publication and Content Type

ref (subject category)
art (subject category)

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By the author/editor: Fromentin, S.; Forslund, S. K.; Chechi, K.; Aron-Wisnewsky, ...; Chakaroun, R.; Nielsen, T.; show more...; Tremaroli, Valen ...; Ji, Boyang, 1983; Prifti, E.; Myridakis, A.; Chilloux, J.; Andrikopoulos, P ...; Fan, Y.; Olanipekun, M. T ...; Alves, R.; Adiouch, S.; Nielsen, Jens B, ...; Talmor-Barkan, Y ...; Belda, E.; Caesar, Robert, ...; Li, Peishun, 198 ...; Falony, G.; Fellahi, S.; Galan, P.; Galleron, N.; Helft, G.; Hoyles, L.; Isnard, R.; Le Chatelier, E.; Julienne, H.; Olsson, Lisa M., ...; Pedersen, H. K.; Pons, N.; Quinquis, B.; Rouault, C.; Roume, H.; Salem, J. E.; Schmidt, T. S. B ...; Vieira-Silva, S.; Li, P. S.; Zimmermann-Kogad ...; Lewinter, C.; Sondertoft, N. B ...; Hansen, T. H.; Gauguier, D.; Gotze, J. P.; Kober, L.; Kornowski, R.; Vestergaard, H.; Hansen, T.; Zucker, J. D.; Hercberg, S.; Letunic, I.; Bäckhed, Fredrik ...; Oppert, J. M.; Nielsen, J.; Raes, J.; Bork, P.; Stumvoll, M.; Segal, E.; Clement, K.; Dumas, M. E.; Ehrlich, S. D.; Pedersen, O.; show less...

About the subject

MEDICAL AND HEALTH SCIENCES: MEDICAL AND HEAL ...; and Clinical Medicin ...; and Cardiac and Card ...

MEDICAL AND HEALTH SCIENCES: MEDICAL AND HEAL ...; and Clinical Medicin ...; and Endocrinology an ...

MEDICAL AND HEALTH SCIENCES: MEDICAL AND HEAL ...; and Clinical Medicin ...; and Other Clinical M ...

MEDICAL AND HEALTH SCIENCES: MEDICAL AND HEAL ...; and Medical Biotechn ...; and Biomedical Labor ...

Articles in the publication: Nature Medicine

By the university: University of Gothenburg; Chalmers University of Technology

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