Sökning: WFRF:(Penney Kathryn L.) >
Genetic variation i...
Genetic variation in RNASEL associated with prostate cancer risk and progression
-
- Meyer, Mara S. (författare)
- Department of Epidemiology, Harvard School of Public Health, Boston, USA
-
- Penney, Kathryn L. (författare)
- Department of Epidemiology, Harvard School of Public Health, Boston, USA
-
- Stark, Jennifer R. (författare)
- Department of Epidemiology, Harvard School of Public Health, Boston, USA
-
visa fler...
-
- Schumacher, Fredrick R. (författare)
- Department of Preventive Medicine, Keck School of Medicine, University of Southern California, Los Angeles, USA
-
- Sesso, Howard D. (författare)
- Division of Preventive Medicine, Department of Medicine, Brigham and Women’s Hospital, Boston, USA
-
- Loda, Massimo (författare)
- Harvard Radiation Oncology Program Brigham and Women’s Hospital/Dana-Farber Cancer Institute, Boston, USA
-
- Fiorentino, Michelangelo (författare)
- Harvard Radiation Oncology Program Brigham and Women’s Hospital/Dana-Farber Cancer Institute, Boston, USA
-
- Finn, Stephen (författare)
- Harvard Radiation Oncology Program Brigham and Women’s Hospital/Dana-Farber Cancer Institute, Boston, USA
-
- Flavin, Richard J. (författare)
- Harvard Radiation Oncology Program Brigham and Women’s Hospital/Dana-Farber Cancer Institute, Boston, USA
-
- Kurth, Tobias (författare)
- Department of Epidemiology, Harvard School of Public Health, Boston, USA; Division of Preventive Medicine, Department of Medicine, Brigham and Women’s Hospital, Boston, USA
-
- Price, Alkes L. (författare)
- Department of Epidemiology, Harvard School of Public Health, Boston, USA; Department of Biostatistics, Harvard School of Public Health, Boston, USA
-
- Giovannucci, Edward L. (författare)
- Department of Epidemiology, Harvard School of Public Health, Boston, USA; Department of Nutrition, Harvard School of Public Health, Boston,USA
-
- Fall, Katja, 1971- (författare)
- Department of Epidemiology, Harvard School of Public Health, Boston, USA; Department of Medical Epidemiology and Biostatistics, Karolinska Institute, Stockholm, Sweden
-
- Stampfer, Meir J. (författare)
- Department of Epidemiology, Harvard School of Public Health, Boston, USA; Channing Laboratory, Department of Medicine, Brigham and Women’s Hospital and Harvard Medical School, Boston, USA
-
- Ma, Jing (författare)
- Channing Laboratory, Department of Medicine, Brigham and Women’s Hospital and Harvard Medical School, Boston, USA
-
- Mucci, Lorelei A. (författare)
- Department of Epidemiology, Harvard School of Public Health, Boston, USA; Channing Laboratory, Department of Medicine, Brigham and Women’s Hospital and Harvard Medical School, Boston, USA
-
visa färre...
-
(creator_code:org_t)
- 2010-06-24
- 2010
- Engelska.
-
Ingår i: Carcinogenesis. - Oxford, United Kingdom : Oxford University Press. - 0143-3334 .- 1460-2180. ; 31:9, s. 1597-603
- Relaterad länk:
-
https://academic.oup...
-
visa fler...
-
https://urn.kb.se/re...
-
https://doi.org/10.1...
-
http://kipublication...
-
visa färre...
Abstract
Ämnesord
Stäng
- Variation in genes contributing to the host immune response may mediate the relationship between inflammation and prostate carcinogenesis. RNASEL at chromosome 1q25 encodes ribonuclease L, part of the interferon-mediated immune response to viral infection. We therefore investigated the association between variation in RNASEL and prostate cancer risk and progression in a study of 1286 cases and 1264 controls nested within the prospective Physicians' Health Study. Eleven single-nucleotide polymorphisms (SNPs) were selected using the web-based 'Tagger' in the HapMap CEPH panel (Utah residents of Northern and Western European Ancestry). Unconditional logistic regression models assessed the relationship between each SNP and incident advanced stage (T(3)/T(4), T(0)-T(4)/M(1) and lethal disease) and high Gleason grade (>/=7) prostate cancer. Further analyses were stratified by calendar year of diagnosis. Cox proportional hazards models examined the relationship between genotype and prostate cancer-specific survival. We also explored associations between genotype and serum inflammatory biomarkers interleukin-6 (IL-6), C-reactive protein (CRP) and tumor necrosis factor-alpha receptor 2 using linear regression. Individuals homozygous for the variant allele of rs12757998 had an increased risk of prostate cancer [AA versus GG; odds ratio (OR): 1.63, 95% confidence interval (CI): 1.18-2.25), and more specifically, high-grade tumors (OR: 1.90, 95% CI: 1.25-2.89). The same genotype was associated with increased CRP (P = 0.02) and IL-6 (P = 0.05) levels. Missense mutations R462Q and D541E were associated with an increased risk of advanced stage disease only in the pre-prostate-specific antigen era. There were no significant associations with survival. The results of this study support a link between RNASEL and prostate cancer and suggest that the association may be mediated through inflammation. These novel findings warrant replication in future studies.
Ämnesord
- MEDICIN OCH HÄLSOVETENSKAP -- Klinisk medicin -- Cancer och onkologi (hsv//swe)
- MEDICAL AND HEALTH SCIENCES -- Clinical Medicine -- Cancer and Oncology (hsv//eng)
Publikations- och innehållstyp
- ref (ämneskategori)
- art (ämneskategori)
Hitta via bibliotek
Till lärosätets databas
- Av författaren/redakt...
-
Meyer, Mara S.
-
Penney, Kathryn ...
-
Stark, Jennifer ...
-
Schumacher, Fred ...
-
Sesso, Howard D.
-
Loda, Massimo
-
visa fler...
-
Fiorentino, Mich ...
-
Finn, Stephen
-
Flavin, Richard ...
-
Kurth, Tobias
-
Price, Alkes L.
-
Giovannucci, Edw ...
-
Fall, Katja, 197 ...
-
Stampfer, Meir J ...
-
Ma, Jing
-
Mucci, Lorelei A ...
-
visa färre...
- Om ämnet
-
- MEDICIN OCH HÄLSOVETENSKAP
-
MEDICIN OCH HÄLS ...
-
och Klinisk medicin
-
och Cancer och onkol ...
- Artiklar i publikationen
-
Carcinogenesis
- Av lärosätet
-
Örebro universitet
-
Karolinska Institutet