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Patterns of sensiti...
Patterns of sensitization to furry animal allergen components in adult asthma and indicators of severity
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Nwaru, Bright (författare)
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Suzuki, Shintaro (författare)
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Ekerljung, Linda (författare)
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Sjölander, Sigrid (författare)
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Mincheva, Roxana (författare)
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Rönmark, Erik (författare)
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- Rönmark, Eva (författare)
- Umeå universitet,Yrkes- och miljömedicin
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Borres, Magnus (författare)
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Lundbäck, Bo (författare)
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Lotvall, Jan (författare)
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(creator_code:org_t)
- European Respiratory Society, 2018
- 2018
- Engelska.
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Ingår i: European Respiratory Journal. - : European Respiratory Society. - 0903-1936 .- 1399-3003. ; 52
- Relaterad länk:
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https://urn.kb.se/re...
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https://doi.org/10.1...
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Abstract
Ämnesord
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- Background: Whilst the role of allergen component sensitization in asthma has been investigated in children, studies in adults are lacking.Aim: To study the relationship between patterns of sensitization to furry animal allergen components and asthma, concomitant asthma/allergic rhinitis, and indicators of asthma severity in a population-representative adult sample.Methods: From the West Sweden Asthma Study, 2006 were clinically phenotyped, of which 1872 had Phadiatop analyzed. Those with IgE>0.35 kUA/L were then analyzed for specific cat (Fel d 1, 2, & 4), dog (Can f 1, 2, 3, & 5), and horse (Equ c 1) allergen components. Sensitization patterns were defined as mono-, double-, and poly-sensitization (i.e. >2 components). Outcomes were current asthma, current allergic rhinitis, concomitant asthma/rhinitis, and indicators of asthma severity.Results: Mono-, double-, and poly-sensitization to furry animal components were each associated with a substantial increased risk of asthma, allergic rhinitis, concomitant asthma/rhinitis, and ACT well-controlled asthma. Poly-sensitization was further associated with increased FeNo (β 0.43, 95%CI 0.18 to 0.68) and eosinophil (β 0.26, 95%CI 0.02 to 0.50) levels, and lower PD20 methacoline values (β -0.57, 95%CI -0.99 to -0.15). Sensitization patterns were not associated with asthma exacerbations, FEV1 values, emergency visits or oral steroid use, and neutrophil levels.Conclusion: Patterns of sensitization to furry animal allergen components are a good predictor of clinical outcomes and indicators of asthma severity in adults, but only poly-sensitization had impact on eosinophilic inflammatory markers of severity.
Ämnesord
- MEDICIN OCH HÄLSOVETENSKAP -- Klinisk medicin -- Lungmedicin och allergi (hsv//swe)
- MEDICAL AND HEALTH SCIENCES -- Clinical Medicine -- Respiratory Medicine and Allergy (hsv//eng)
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Nwaru, Bright
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Suzuki, Shintaro
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Ekerljung, Linda
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Sjölander, Sigri ...
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Mincheva, Roxana
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Rönmark, Erik
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visa fler...
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Rönmark, Eva
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Borres, Magnus
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Lundbäck, Bo
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Lotvall, Jan
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visa färre...
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