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Prevalence of the a...
Prevalence of the apolipoprotein E epsilon 4 allele in amyloid beta positive subjects across the spectrum of Alzheimers disease
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- Mattsson, Niklas (author)
- Lund Univ, Sweden
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- Groot, Colin (author)
- Vrije Univ Amsterdam, Netherlands; Vrije Univ Amsterdam, Netherlands
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- Jansen, Willemijn J. (author)
- Maastricht Univ, Netherlands
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- Landau, Susan M. (author)
- Univ Calif Berkeley, CA 94720 USA
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- Villemagne, Victor L. (author)
- Austin Hlth, Australia; Austin Hlth, Australia
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- Engelborghs, Sebastiaan (author)
- Univ Antwerp, Belgium
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- Mintun, Mark M. (author)
- Avid Radiopharmaceut, PA USA
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- Lleo, Alberto (author)
- Hosp Santa Creu and Sant Pau, Spain
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- Molinuevo, Jose Luis (author)
- Clin Univ Hosp, Spain
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- Jagust, William J. (author)
- Univ Calif Berkeley, CA 94720 USA
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- Frisoni, Giovanni B. (author)
- Univ Hosp, Switzerland; Univ Hosp, Switzerland; Univ Geneva, Switzerland; IRCCS, Italy
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- Ivanoiu, Adrian (author)
- Clin Univ Hosp, Spain; Catholic Univ Louvain, Belgium; Catholic Univ Louvain, Belgium
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- Chetelat, Gael (author)
- Univ Caen Normandie, France
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- de Oliveira, Catarina Resende (author)
- CHU Coimbra, Portugal
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- Rodrigue, Karen M. (author)
- Univ Texas Dallas, TX USA
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- Kornhuber, Johannes (author)
- Friedrich Alexander Univ Erlangen Nuremberg, Germany
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- Wallin, Anders (author)
- Univ Gothenburg, Sweden
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- Klimkowicz-Mrowiec, Aleksandra (author)
- Jagiellonian Univ, Poland
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- Kandimalla, Ramesh (author)
- Postgrad Inst Med Educ and Res PGIMER, India
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- Popp, Julius (author)
- Univ Hosp Lausanne, Switzerland
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- Aalten, Pauline P. (author)
- Maastricht Univ, Netherlands
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- Aarsland, Dag (author)
- Stavanger Univ Hosp, Norway
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- Alcolea, Daniel (author)
- Hosp Santa Creu and Sant Pau, Spain
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- Almdahl, Ina S. (author)
- Akershus Univ Hosp, Norway
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- Baldeiras, Ines (author)
- CHU Coimbra, Portugal
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- van Buchem, Mark A. (author)
- Leiden Univ, Netherlands
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- Cavedo, Enrica (author)
- IRCCS, Italy; Univ Pierre and Marie Curie UPMC Paris 06, France
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- Chen, Kewei (author)
- Banner Alzheimers Inst, AZ USA
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- Cohen, Ann D. (author)
- Univ Pittsburgh, PA USA
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- Foerster, Stefan (author)
- Tech Univ Munich, Germany
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- Fortea, Juan (author)
- Hosp Santa Creu and Sant Pau, Spain
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- Frederiksen, Kristian S. (author)
- Univ Copenhagen, Denmark
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- Freund-Levi, Yvonne (author)
- Karolinska Univ, Sweden
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- Gill, Kiran Dip (author)
- Postgrad Inst Med Educ and Res PGIMER, India
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- Gkatzima, Olymbia (author)
- Aristotle Univ Thessaloniki, Greece
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- Grimmer, Timo (author)
- Techn Univ Munchen, Germany
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- Hampel, Harald (author)
- Univ Pierre and Marie Curie UPMC Paris 06, France; Ludwig Maximilians Univ Munchen, Germany; Ludwig Maximilians Univ Munchen, Germany
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- Herukka, Sanna-Kaisa (author)
- Univ Eastern Finland, Finland; Kuopio Univ Hosp, Finland
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- Johannsen, Peter (author)
- Rigshosp, Denmark
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- van Laere, Koen (author)
- Katholieke Univ Leuven, Belgium
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- de Leon, Mony J. (author)
- NYU, NY USA
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- Maier, Wolfgang (author)
- Univ Bonn, Germany
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- Marcusson, Jan (author)
- Linköpings universitet,Avdelningen för neuro- och inflammationsvetenskap,Medicinska fakulteten,Region Östergötland, Medicinska och geriatriska akutkliniken
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- Meulenbroek, Olga (author)
- Radboud Univ Nijmegen, Netherlands
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- Mollergard, Hanne M. (author)
- Akershus Univ Hosp, Norway
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- Morris, John C. (author)
- Washington Univ, MO 63110 USA
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- Mroczko, Barbara (author)
- Med Univ Bialystok, Poland
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- Nordlund, Arto (author)
- Univ Gothenburg, Sweden
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- Prabhakar, Sudesh (author)
- Postgrad Inst Med Educ and Res PGIMER, India
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- Peters, Oliver (author)
- German Ctr Neurodegenerat Dis DZNE, Germany
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- Rami, Lorena (author)
- Clin Univ Hosp, Spain
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- Rodriguez-Rodriguez, Eloy (author)
- Univ Hosp Marques Valdecilla, Spain
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- Roe, Catherine M. (author)
- Washington Univ, MO 63110 USA
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- Ruther, Eckart (author)
- Georg August Univ, Germany
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- Santana, Isabel (author)
- CHU Coimbra, Portugal
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- Schroder, Johannes (author)
- Heidelberg Univ, Germany
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- Seo, Sang W. (author)
- Sungkyunkwan Univ, South Korea
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- Soininen, Hilkka (author)
- Univ Eastern Finland, Finland; Kuopio Univ Hosp, Finland
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- Spiru, Luiza (author)
- Carol Davila Univ Med and Pharm, Romania
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- Stomrud, Erik (author)
- Lund Univ, Sweden
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- Struyfs, Hanne (author)
- Univ Antwerp, Belgium
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- Teunissen, Charlotte E. (author)
- Vrije Univ Amsterdam, Netherlands; Vrije Univ Amsterdam, Netherlands
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- Verhey, Frans R. J. (author)
- Maastricht Univ, Netherlands
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- Vos, Stephanie J. B. (author)
- Maastricht Univ, Netherlands
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- van Doorn, Linda J. C. van Waalwijk (author)
- Radboud Univ Nijmegen, Netherlands; Radboud Univ Nijmegen, Netherlands
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- Waldemar, Gunhild (author)
- Univ Copenhagen, Denmark
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- Wallin, Asa K. (author)
- Lund Univ, Sweden
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- Wiltfang, Jens (author)
- Georg August Univ, Germany; Georg August Univ, Germany
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- Vandenberghe, Rik (author)
- Katholieke Univ Leuven, Belgium; Katholieke Univ Leuven, Belgium
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- Brooks, David J. (author)
- Imperial Coll London, England
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- Fladby, Tormod (author)
- Akershus Univ Hosp, Norway
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- Rowe, Christopher C. (author)
- Austin Hlth, Australia; Austin Hlth, Australia
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- Drzezga, Alexander (author)
- Univ Cologne, Germany
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- Verbeek, Marcel M. (author)
- Radboud Univ Nijmegen, Netherlands; Radboud Univ Nijmegen, Netherlands
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- Sarazin, Marie (author)
- Sorbonne Paris Cite, France
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- Wolk, David A. (author)
- Univ Penn, PA 19104 USA
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- Fleisher, Adam S. (author)
- Banner Alzheimers Inst, AZ USA; Eli Lilly, IN USA; Univ Calif San Diego, CA 92103 USA
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- Klunk, William E. (author)
- Univ Pittsburgh, PA USA
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- Na, Duk L. (author)
- Sungkyunkwan Univ, South Korea
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- Sanchez-Juan, Pascual (author)
- Univ Hosp Marques Valdecilla, Spain
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- Lee, Dong Young (author)
- Seoul Natl Univ, South Korea
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- Nordberg, Agneta (author)
- Karolinska Univ Hosp, Sweden
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- Tsolaki, Magda (author)
- Aristotle Univ Thessaloniki, Greece
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- Camus, Vincent (author)
- Univ Francois Rabelais Tours, France
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- Rinne, Juha O. (author)
- Univ Turku, Finland; Univ Turku, Finland; Turku Univ Hosp, Finland
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- Fagan, Anne M. (author)
- Washington Univ, MO 63110 USA
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- Zetterberg, Henrik (author)
- UCL, England; UK Dementia Res Inst, England; Univ Gothenburg, Sweden; Sahlgrens Univ Hosp, Sweden
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- Blennow, Kaj (author)
- Univ Gothenburg, Sweden; Sahlgrens Univ Hosp, Sweden
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- Rabinovici, Gil D. (author)
- Univ Calif San Francisco, CA 94143 USA
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- Hansson, Oskar (author)
- Lund Univ, Sweden
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- van Berckel, Bart N. M. (author)
- Vrije Univ Amsterdam, Netherlands
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- van der Flier, Wiesje M. (author)
- Vrije Univ Amsterdam, Netherlands; Vrije Univ Amsterdam, Netherlands; Vrije Univ Amsterdam, Netherlands
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- Scheltens, Philip (author)
- Vrije Univ Amsterdam, Netherlands; Vrije Univ Amsterdam, Netherlands
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- Visser, Pieter Jelle (author)
- Vrije Univ Amsterdam, Netherlands; Vrije Univ Amsterdam, Netherlands; Maastricht Univ, Netherlands
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- Ossenkoppele, Rik (author)
- Lund Univ, Sweden; Vrije Univ Amsterdam, Netherlands; Vrije Univ Amsterdam, Netherlands; Vrije Univ Amsterdam, Netherlands
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(creator_code:org_t)
- 2018-03-27
- 2018
- English.
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In: Alzheimer's & Dementia. - : ELSEVIER SCIENCE INC. - 1552-5260 .- 1552-5279. ; 14:7, s. 913-924
- Related links:
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https://lirias.kuleu...
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https://urn.kb.se/re...
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https://doi.org/10.1...
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Abstract
Subject headings
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- Introduction: Apolipoprotein E (APOE) epsilon 4 is the major genetic risk factor for Alzheimers disease (AD), but its prevalence is unclear because earlier studies did not require biomarker evidence of amyloid beta(A beta) pathology. Methods: We included 3451 A beta+ subjects (853 AD-type dementia, 1810 mild cognitive impairment, and 788 cognitively normal). Generalized estimating equation models were used to assess APOE epsilon 4 prevalence in relation to age, sex, education, and geographical location. Results: The APOE epsilon 4 prevalence was 66% in AD-type dementia, 64% in mild cognitive impairment, and 51% in cognitively normal, and it decreased with advancing age in A beta+ cognitively normal and A beta+ mild cognitive impairment (P amp;lt;.05) but not in A beta+ AD dementia (P =.66). The prevalence was highest in Northern Europe but did not vary by sex or education. Discussion: The APOE E4 prevalence in AD was higher than that in previous studies, which did not require presence of A beta pathology. Furthermore, our results highlight disease heterogeneity related to age and geographical location. (C) 2018 the Alzheimers Association. Published by Elsevier Inc. All rights reserved.
Subject headings
- MEDICIN OCH HÄLSOVETENSKAP -- Klinisk medicin -- Geriatrik (hsv//swe)
- MEDICAL AND HEALTH SCIENCES -- Clinical Medicine -- Geriatrics (hsv//eng)
Keyword
- APOE; Prevalence; Amyloid; PET; CSF; Alzheimers disease; Mild cognitive impairment; Subjective cognitive decline; Age; Sex; Education; Geographical location
Publication and Content Type
- ref (subject category)
- art (subject category)
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Mattsson, Niklas
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Groot, Colin
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Jansen, Willemij ...
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Landau, Susan M.
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Villemagne, Vict ...
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Engelborghs, Seb ...
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show more...
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Mintun, Mark M.
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Lleo, Alberto
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Molinuevo, Jose ...
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Jagust, William ...
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Frisoni, Giovann ...
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Ivanoiu, Adrian
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Chetelat, Gael
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de Oliveira, Cat ...
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Rodrigue, Karen ...
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Kornhuber, Johan ...
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Wallin, Anders
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Klimkowicz-Mrowi ...
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Kandimalla, Rame ...
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Popp, Julius
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Aalten, Pauline ...
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Aarsland, Dag
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Alcolea, Daniel
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Almdahl, Ina S.
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Baldeiras, Ines
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van Buchem, Mark ...
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Cavedo, Enrica
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Chen, Kewei
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Cohen, Ann D.
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Foerster, Stefan
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Fortea, Juan
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Frederiksen, Kri ...
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Freund-Levi, Yvo ...
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Gill, Kiran Dip
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Gkatzima, Olymbi ...
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Grimmer, Timo
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Hampel, Harald
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Herukka, Sanna-K ...
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Johannsen, Peter
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van Laere, Koen
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de Leon, Mony J.
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Maier, Wolfgang
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Marcusson, Jan
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Meulenbroek, Olg ...
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Mollergard, Hann ...
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Morris, John C.
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Mroczko, Barbara
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Nordlund, Arto
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Prabhakar, Sudes ...
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Peters, Oliver
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Rami, Lorena
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Rodriguez-Rodrig ...
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Roe, Catherine M ...
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Ruther, Eckart
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Santana, Isabel
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Schroder, Johann ...
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Seo, Sang W.
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Soininen, Hilkka
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Spiru, Luiza
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Stomrud, Erik
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Struyfs, Hanne
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Teunissen, Charl ...
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Verhey, Frans R. ...
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Vos, Stephanie J ...
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van Doorn, Linda ...
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Waldemar, Gunhil ...
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Wallin, Asa K.
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Wiltfang, Jens
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Vandenberghe, Ri ...
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Brooks, David J.
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Fladby, Tormod
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Rowe, Christophe ...
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Drzezga, Alexand ...
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Verbeek, Marcel ...
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Sarazin, Marie
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Wolk, David A.
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Fleisher, Adam S ...
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Klunk, William E ...
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Na, Duk L.
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Sanchez-Juan, Pa ...
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Lee, Dong Young
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Nordberg, Agneta
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Tsolaki, Magda
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Camus, Vincent
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Rinne, Juha O.
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Fagan, Anne M.
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Zetterberg, Henr ...
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Blennow, Kaj
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Rabinovici, Gil ...
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Hansson, Oskar
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van Berckel, Bar ...
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van der Flier, W ...
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Scheltens, Phili ...
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Visser, Pieter J ...
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Ossenkoppele, Ri ...
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- About the subject
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- MEDICAL AND HEALTH SCIENCES
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MEDICAL AND HEAL ...
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and Clinical Medicin ...
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and Geriatrics
- Articles in the publication
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Alzheimer's & De ...
- By the university
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Linköping University