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Follicular fluid an...
Follicular fluid and blood levels of persistent organic pollutants and reproductive outcomes among women undergoing assisted reproductive technologies
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- Bjorvang, Richelle D. (författare)
- Karolinska Institutet,Karolinska Inst, Dept Clin Sci Intervent & Technol, Div Obstet & Gynecol, S-14186 Stockholm, Sweden.;Karolinska Univ Hosp Huddinge, S-14186 Stockholm, Sweden.,Karolinska University Hospital
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- Hallberg, Ida (författare)
- Sveriges lantbruksuniversitet,Swedish University of Agricultural Sciences,Institutionen för kliniska vetenskaper (KV),Department of Clinical Sciences
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- Pikki, Anne (författare)
- Uppsala University,Uppsala universitet,Institutionen för kvinnors och barns hälsa,Carl von Linnekliniken, S-75183 Uppsala, Sweden.
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- Berglund, Lars, Docent, 1955- (författare)
- Dalarna University College,Högskolan Dalarna,Uppsala universitet,Uppsala kliniska forskningscentrum (UCR),Geriatrik,Institutionen för medicinska vetenskaper,Dalarna Univ, Sch Hlth & Welf, S-79188 Falun, Sweden.,Medicinsk vetenskap,Uppsala University
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- Pedrelli, Matteo (författare)
- Karolinska Institute,Karolinska Institutet,Karolinska Inst, Dept Lab Med, Cardio Metab Unit, S-14152 Stockholm, Sweden.;Karolinska Inst, Dept Med, S-14152 Stockholm, Sweden.;Karolinska Univ Hosp, Med Unit Endocrinol, Theme Inflammat & Ageing, S-14186 Stockholm, Sweden.,Karolinska University Hospital
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- Kiviranta, Hannu (författare)
- Finnish Inst Hlth & Welf, Dept Hlth Secur, Kuopio 70701, Finland.,Finnish National Institute for Health and Welfare
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- Rantakokko, Panu (författare)
- Finnish Inst Hlth & Welf, Dept Hlth Secur, Kuopio 70701, Finland.,Finnish National Institute for Health and Welfare
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- Ruokojarvi, Paivi (författare)
- Finnish Inst Hlth & Welf, Dept Hlth Secur, Kuopio 70701, Finland.
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- Lindh, Christian H. (författare)
- Lund University,Lunds universitet,Avdelningen för arbets- och miljömedicin,Institutionen för laboratoriemedicin,Medicinska fakulteten,Division of Occupational and Environmental Medicine, Lund University,Department of Laboratory Medicine,Faculty of Medicine
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- Olovsson, Matts, 1958- (författare)
- Uppsala University,Uppsala universitet,Reproduktionsbiologi
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- Persson, Sara (författare)
- Sveriges lantbruksuniversitet,Swedish University of Agricultural Sciences,Institutionen för kliniska vetenskaper (KV),Department of Clinical Sciences
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- Holte, Jan (författare)
- Uppsala University,Uppsala universitet,Reproduktionsbiologi,Carl von Linnekliniken, S-75183 Uppsala, Sweden.
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- Sjunnesson, Ylva (författare)
- Sveriges lantbruksuniversitet,Swedish University of Agricultural Sciences,Uppsala universitet,Reproduktionsbiologi,Institutionen för kliniska vetenskaper (KV),Department of Clinical Sciences
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- Damdimopoulou, Pauliina (författare)
- Karolinska Institutet,Karolinska Inst, Dept Clin Sci Intervent & Technol, Div Obstet & Gynecol, S-14186 Stockholm, Sweden.;Karolinska Univ Hosp Huddinge, S-14186 Stockholm, Sweden.,Karolinska University Hospital
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Karolinska Institutet Karolinska Inst, Dept Clin Sci Intervent & Technol, Div Obstet & Gynecol, S-14186 Stockholm, Sweden;Karolinska Univ Hosp Huddinge, S-14186 Stockholm, Sweden. (creator_code:org_t)
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- Elsevier, 2022
- 2022
- Engelska.
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Ingår i: Environmental Research. - : Elsevier. - 0013-9351 .- 1096-0953. ; 208
- Relaterad länk:
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https://doi.org/10.1...
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https://uu.diva-port... (primary) (Raw object)
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https://pub.epsilon.... (primary) (Raw object) (free)
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https://urn.kb.se/re...
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https://doi.org/10.1...
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http://kipublication...
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https://urn.kb.se/re...
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Abstract
Ämnesord
Stäng
- Persistent organic pollutants (POPs) are industrial chemicals resistant to degradation and have been shown to have adverse effects on reproductive health in wildlife and humans. Although regulations have reduced their levels, they are still ubiquitously present and pose a global concern. Here, we studied a cohort of 185 women aged 21-43 years with a median of 2 years of infertility who were seeking assisted reproductive technology (ART) treatment at the Carl von Linne Clinic in Uppsala, Sweden. We analyzed the levels of 9 organochlorine pesticides (OCPs), 10 polychlorinated biphenyls (PCBs), 3 polybrominated diphenyl ethers (PBDEs), and 8 perfluoroalkyl substances (PFASs) in the blood and follicular fluid (FF) samples collected during ovum pick-up. Impact of age on chemical transfer from blood to FF was analyzed. Associations of chemicals, both individually and as a mixture, to 10 ART endpoints were investigated using linear, logistic, and weighted quantile sum regression, adjusted for age, body mass index, parity, fatty fish intake and cause of infertility. Out of the 30 chemicals, 20 were detected in more than half of the blood samples and 15 in FF. Chemical transfer from blood to FF increased with age. Chemical groups in blood crossed the blood-follicle barrier at different rates: OCPs > PCBs > PFASs. Hexachlorobenzene, an OCP, was associated with lower anti-Miillerian hormone, clinical pregnancy, and live birth. PCBs and PFASs were associated with higher antral follicle count and ovarian response as measured by ovarian sensitivity index, but also with lower embryo quality. As a mixture, similar findings were seen for the sum of PCBs and PFASs. Our results suggest that age plays a role in the chemical transfer from blood to FF and that exposure to POPs significantly associates with ART outcomes. We strongly encourage further studies to elucidate the underlying mechanisms of reproductive effects of POPs in humans.
Ämnesord
- MEDICIN OCH HÄLSOVETENSKAP -- Hälsovetenskap -- Arbetsmedicin och miljömedicin (hsv//swe)
- MEDICAL AND HEALTH SCIENCES -- Health Sciences -- Occupational Health and Environmental Health (hsv//eng)
- MEDICIN OCH HÄLSOVETENSKAP -- Klinisk medicin -- Reproduktionsmedicin och gynekologi (hsv//swe)
- MEDICAL AND HEALTH SCIENCES -- Clinical Medicine -- Obstetrics, Gynaecology and Reproductive Medicine (hsv//eng)
- NATURVETENSKAP -- Geovetenskap och miljövetenskap -- Miljövetenskap (hsv//swe)
- NATURAL SCIENCES -- Earth and Related Environmental Sciences -- Environmental Sciences (hsv//eng)
Nyckelord
- Persistent organic pollutants
- Assisted reproductive technologies
- Follicular fluid
- Ovarian sensitivity index
- Embryo quality
- Live birth
- Assisted reproductive technologies
- Embryo quality
- Follicular fluid
- Live birth
- Ovarian sensitivity index
- Persistent organic pollutants
Publikations- och innehållstyp
- ref (ämneskategori)
- art (ämneskategori)
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Till lärosätets databas
- Av författaren/redakt...
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Bjorvang, Richel ...
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Hallberg, Ida
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Pikki, Anne
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Berglund, Lars, ...
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Pedrelli, Matteo
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Kiviranta, Hannu
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visa fler...
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Rantakokko, Panu
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Ruokojarvi, Paiv ...
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Lindh, Christian ...
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Olovsson, Matts, ...
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Persson, Sara
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Holte, Jan
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Sjunnesson, Ylva
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Damdimopoulou, P ...
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- Om ämnet
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- MEDICIN OCH HÄLSOVETENSKAP
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MEDICIN OCH HÄLS ...
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och Hälsovetenskap
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och Arbetsmedicin oc ...
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- MEDICIN OCH HÄLSOVETENSKAP
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MEDICIN OCH HÄLS ...
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och Klinisk medicin
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och Reproduktionsmed ...
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- NATURVETENSKAP
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NATURVETENSKAP
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och Geovetenskap och ...
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och Miljövetenskap
- Artiklar i publikationen
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Environmental Re ...
- Av lärosätet
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Uppsala universitet
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Karolinska Institutet
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Högskolan Dalarna
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Lunds universitet
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Sveriges Lantbruksuniversitet