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Comprehensive Trans...
Comprehensive Transcriptional Analysis of Early-Stage Urothelial Carcinoma
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- Hedegaard, Jakob (author)
- Aarhus Univ Hosp, Dept Mol Med, DK-8200 Aarhus, Denmark.,Aarhus University Hospital
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- Lamy, Philippe (author)
- Aarhus Univ Hosp, Dept Mol Med, DK-8200 Aarhus, Denmark.,Aarhus University Hospital
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- Nordentoft, Iver (author)
- Aarhus Univ Hosp, Dept Mol Med, DK-8200 Aarhus, Denmark.,Aarhus University Hospital
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- Algaba, Ferran (author)
- Univ Autonoma Barcelona, Fundacio Puigvert, Sect Pathol, Barcelona 08025, Spain.,Autonomous University of Barcelona
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- Hoyer, Soren (author)
- Aarhus Univ Hosp, Dept Pathol, DK-8000 Aarhus, Denmark.,Aarhus University Hospital
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- Ulhoi, Benedicte Parm (author)
- Aarhus Univ Hosp, Dept Pathol, DK-8000 Aarhus, Denmark.,Aarhus University Hospital
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- Vang, Soren (author)
- Aarhus Univ Hosp, Dept Mol Med, DK-8200 Aarhus, Denmark.,Aarhus University Hospital
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- Reinert, Thomas (author)
- Aarhus Univ Hosp, Dept Mol Med, DK-8200 Aarhus, Denmark.,Aarhus University Hospital
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- Hermann, Gregers G. (author)
- Frederiksberg Univ Hosp, Dept Urol, DK-2000 Frederiksberg, Denmark.,Frederiksberg Hospital
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- Mogensen, Karin (author)
- Frederiksberg Univ Hosp, Dept Urol, DK-2000 Frederiksberg, Denmark.,Frederiksberg Hospital
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- Thomsen, Mathilde Borg Houlberg (author)
- Aarhus Univ Hosp, Dept Mol Med, DK-8200 Aarhus, Denmark.,Aarhus University Hospital
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- Nielsen, Morten Muhlig (author)
- Aarhus Univ Hosp, Dept Mol Med, DK-8200 Aarhus, Denmark.,Aarhus University Hospital
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- Marquez, Mirari (author)
- Spanish Natl Canc Res Ctr CNIO, Madrid 28029, Spain.,Spanish National Cancer Research Center (CNIO),University of Vic,Erasmus University Medical Center
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- Segersten, Ulrika (author)
- Uppsala University,Uppsala universitet,Urologkirurgi
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- Aine, Mattias (author)
- Lund University,Lunds universitet,Bröstcancer-genetik,Sektion I,Institutionen för kliniska vetenskaper, Lund,Medicinska fakulteten,Breastcancer-genetics,Section I,Department of Clinical Sciences, Lund,Faculty of Medicine
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- Höglund, Mattias (author)
- Lund University,Lunds universitet,Bröstcancer-genetik,Sektion I,Institutionen för kliniska vetenskaper, Lund,Medicinska fakulteten,Breastcancer-genetics,Section I,Department of Clinical Sciences, Lund,Faculty of Medicine
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- Birkenkamp-Demtroder, Karin (author)
- Aarhus Univ Hosp, Dept Mol Med, DK-8200 Aarhus, Denmark.,Aarhus University Hospital
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- Fristrup, Niels (author)
- Aarhus Univ Hosp, Dept Mol Med, DK-8200 Aarhus, Denmark.,Aarhus University Hospital
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- Borre, Michael (author)
- Aarhus Univ Hosp, Dept Urol, DK-8200 Aarhus, Denmark.,Aarhus University Hospital
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- Hartmann, Arndt (author)
- Univ Erlangen Nurnberg, Univ Hosp Erlangen, Inst Pathol, D-91054 Erlangen, Germany.,Friedrich-Alexander University Erlangen-Nürnberg
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- Stoehr, Robert (author)
- Univ Erlangen Nurnberg, Univ Hosp Erlangen, Inst Pathol, D-91054 Erlangen, Germany.,Friedrich-Alexander University Erlangen-Nürnberg
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- Wach, Sven (author)
- Univ Erlangen Nurnberg, Univ Hosp Erlangen, Dept Urol, D-91054 Erlangen, Germany.,Friedrich-Alexander University Erlangen-Nürnberg
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- Keck, Bastian (author)
- Univ Erlangen Nurnberg, Univ Hosp Erlangen, Dept Urol, D-91054 Erlangen, Germany.,Friedrich-Alexander University Erlangen-Nürnberg
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- Seitz, Anna Katharina (author)
- Tech Univ Munich, Klinikum Rechts Isar, Dept Urol, D-81675 Munich, Germany.
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- Nawroth, Roman (author)
- Tech Univ Munich, Klinikum Rechts Isar, Dept Urol, D-81675 Munich, Germany.
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- Maurer, Tobias (author)
- Tech Univ Munich, Klinikum Rechts Isar, Dept Urol, D-81675 Munich, Germany.
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- Tulic, Cane (author)
- Univ Belgrade, Clin Ctr Serbia, Clin Urol, Fac Med, Belgrade 11000, Serbia.,University of Belgrade
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- Simic, Tatjana (author)
- Univ Belgrade, Fac Med, Inst Med & Clin Biochem, Belgrade 11000, Serbia.,University of Belgrade
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- Junker, Kerstin (author)
- Univ Saarland, Dept Urol, D-66421 Homburg, Germany.,Saarland University
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- Horstmann, Marcus (author)
- Univ Jena, Dept Urol, D-07737 Jena, Germany.,Friedrich Schiller University Jena
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- Harving, Niels (author)
- Aalborg Univ Hosp, Dept Urol, DK-9000 Aalborg, Denmark.,Aalborg University Hospital
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- Petersen, Astrid Christine (author)
- Aalborg Univ Hosp, Dept Pathol, DK-9000 Aalborg, Denmark.,Aalborg University Hospital
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- Luz Calle, M. (author)
- Univ Vic, Dept Syst Biol, Barcelona 08500, Spain.
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- Steyerberg, Ewout W. (author)
- Erasmus MC, Dept Publ Hlth, NL-3015 CE Rotterdam, Netherlands.,Erasmus University Medical Center
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- Beukers, Willemien (author)
- Erasmus MC, Dept Pathol, NL-3015 CE Rotterdam, Netherlands.,Erasmus University Medical Center
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- van Kessel, Kim E. M. (author)
- Erasmus MC, Dept Pathol, NL-3015 CE Rotterdam, Netherlands.
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- Jensen, Jorgen Bjerggaard (author)
- Aarhus Univ Hosp, Dept Urol, DK-8200 Aarhus, Denmark.,Aarhus University Hospital
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- Pedersen, Jakob Skou (author)
- Aarhus Univ Hosp, Dept Mol Med, DK-8200 Aarhus, Denmark.,Aarhus University Hospital
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- Malmström, Per-Uno (author)
- Uppsala University,Uppsala universitet,Urologkirurgi
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- Malats, Nuria (author)
- Spanish Natl Canc Res Ctr CNIO, Madrid 28029, Spain.,Spanish National Cancer Research Center (CNIO)
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- Real, Francisco X. (author)
- Spanish Natl Canc Res Ctr CNIO, Madrid 28029, Spain.;Univ Pompeu Fabra, Dept Ciencies Expt & Salut, Barcelona 08003, Spain.,Pompeu Fabra University
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- Zwarthoff, Ellen C. (author)
- Erasmus MC, Dept Pathol, NL-3015 CE Rotterdam, Netherlands.,Erasmus University Medical Center
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- Orntoft, Torben Falck (author)
- Aarhus Univ Hosp, Dept Mol Med, DK-8200 Aarhus, Denmark.,Aarhus University Hospital
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- Dyrskjot, Lars (author)
- Aarhus Univ Hosp, Dept Mol Med, DK-8200 Aarhus, Denmark.,Aarhus University Hospital
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Aarhus Univ Hosp, Dept Mol Med, DK-8200 Aarhus, Denmark Aarhus University Hospital (creator_code:org_t)
- Elsevier BV, 2016
- 2016
- English.
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In: Cancer Cell. - : Elsevier BV. - 1535-6108 .- 1878-3686. ; 30:1, s. 27-42
- Related links:
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http://www.cell.com/...
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http://dx.doi.org/10...
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https://urn.kb.se/re...
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https://doi.org/10.1...
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https://lup.lub.lu.s...
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Abstract
Subject headings
Close
- Non-muscle-invasive bladder cancer (NMIBC) is a heterogeneous disease with widely different outcomes. We performed a comprehensive transcriptional analysis of 460 early-stage urothelial carcinomas and showed that NMIBC can be subgrouped into three major classes with basal-and luminal-like characteristics and different clinical outcomes. Large differences in biological processes such as the cell cycle, epithelial-mesenchymal transition, and differentiation were observed. Analysis of transcript variants revealed frequent mutations in genes encoding proteins involved in chromatin organization and cytoskeletal functions. Furthermore, mutations in well-known cancer driver genes (e.g., TP53 and ERBB2) were primarily found in high-risk tumors, together with APOBEC-related mutational signatures. The identification of subclasses in NMIBC may offer better prognostication and treatment selection based on subclass assignment.
Subject headings
- MEDICIN OCH HÄLSOVETENSKAP -- Klinisk medicin -- Cancer och onkologi (hsv//swe)
- MEDICAL AND HEALTH SCIENCES -- Clinical Medicine -- Cancer and Oncology (hsv//eng)
- MEDICIN OCH HÄLSOVETENSKAP -- Klinisk medicin -- Urologi och njurmedicin (hsv//swe)
- MEDICAL AND HEALTH SCIENCES -- Clinical Medicine -- Urology and Nephrology (hsv//eng)
- MEDICIN OCH HÄLSOVETENSKAP -- Medicinska och farmaceutiska grundvetenskaper -- Cell- och molekylärbiologi (hsv//swe)
- MEDICAL AND HEALTH SCIENCES -- Basic Medicine -- Cell and Molecular Biology (hsv//eng)
- MEDICIN OCH HÄLSOVETENSKAP -- Medicinska och farmaceutiska grundvetenskaper -- Medicinsk genetik (hsv//swe)
- MEDICAL AND HEALTH SCIENCES -- Basic Medicine -- Medical Genetics (hsv//eng)
Publication and Content Type
- ref (subject category)
- art (subject category)
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To the university's database
- By the author/editor
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Hedegaard, Jakob
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Lamy, Philippe
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Nordentoft, Iver
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Algaba, Ferran
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Hoyer, Soren
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Ulhoi, Benedicte ...
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show more...
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Vang, Soren
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Reinert, Thomas
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Hermann, Gregers ...
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Mogensen, Karin
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Thomsen, Mathild ...
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Nielsen, Morten ...
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Marquez, Mirari
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Segersten, Ulrik ...
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Aine, Mattias
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Höglund, Mattias
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Birkenkamp-Demtr ...
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Fristrup, Niels
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Borre, Michael
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Hartmann, Arndt
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Stoehr, Robert
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Wach, Sven
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Keck, Bastian
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Seitz, Anna Kath ...
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Nawroth, Roman
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Maurer, Tobias
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Tulic, Cane
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Simic, Tatjana
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Junker, Kerstin
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Horstmann, Marcu ...
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Harving, Niels
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Petersen, Astrid ...
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Luz Calle, M.
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Steyerberg, Ewou ...
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Beukers, Willemi ...
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van Kessel, Kim ...
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Jensen, Jorgen B ...
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Pedersen, Jakob ...
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Malmström, Per-U ...
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Malats, Nuria
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Real, Francisco ...
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Zwarthoff, Ellen ...
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Orntoft, Torben ...
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Dyrskjot, Lars
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- About the subject
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- MEDICAL AND HEALTH SCIENCES
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MEDICAL AND HEAL ...
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and Clinical Medicin ...
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and Cancer and Oncol ...
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- MEDICAL AND HEALTH SCIENCES
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MEDICAL AND HEAL ...
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and Clinical Medicin ...
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and Urology and Neph ...
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- MEDICAL AND HEALTH SCIENCES
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MEDICAL AND HEAL ...
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and Basic Medicine
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and Cell and Molecul ...
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- MEDICAL AND HEALTH SCIENCES
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MEDICAL AND HEAL ...
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and Basic Medicine
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and Medical Genetics
- Articles in the publication
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Cancer Cell
- By the university
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Uppsala University
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Lund University