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Acute and chronic h...
Acute and chronic hyperglycemic effects of vasopressin in normal rats : Involvement of V1A receptors
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- Taveau, Christopher (author)
- Paris Descartes University
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- Chollet, Catherine (author)
- Paris Descartes University
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- Bichet, Daniel G. (author)
- Sacré-Coeur Hospital
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- Velho, Gilberto (author)
- Institut Gustave Roussy
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- Guillon, Gilles (author)
- University of Montpellier
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- Corbani, Maithe (author)
- University of Montpellier
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- Roussel, Ronan (author)
- Paris Diderot University
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- Bankir, Lise (author)
- Paris Descartes University
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- Melander, Olle (author)
- Lund University,Lunds universitet,Institutionen för kliniska vetenskaper, Malmö,Medicinska fakulteten,Department of Clinical Sciences, Malmö,Faculty of Medicine,Skåne University Hospital
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- Bouby, Nadine (author)
- Paris Descartes University
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(creator_code:org_t)
- American Physiological Society, 2017
- 2017
- English.
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In: American Journal of Physiology - Endocrinology and Metabolism. - : American Physiological Society. - 0193-1849 .- 1522-1555. ; 312:3, s. 127-135
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http://dx.doi.org/10...
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https://lup.lub.lu.s...
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https://doi.org/10.1...
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Abstract
Subject headings
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- Recent epidemiological studies have revealed novel relationships between low water intake or high vasopressin (AVP) and the risk of hyperglycemia and diabetes. AVP V1A and V1B receptors (R) are expressed in the liver and pancreatic islets, respectively. The present study was designed to determine the impact of different levels of circulating AVP on glucose homeostasis in normal Sprague-Dawley rats, as well as the respective roles of V1AR and V1BR. We showed that acute injection of AVP induces a dosedependent increase in glycemia. Pretreatment with a selective V1AR antagonist, but not a V1BR antagonist, dose-dependently prevented the rise in glycemia. V1BR antagonism did not modify the hyperinsulinemic response, resulting from AVP-induced hyperglycemia, but enhanced the fall in glucagonemia. Acute administration of selective V1AR or V1BR agonists confirmed the involvement of V1AR in the hyperglycemic effect of AVP. In chronic experiments, AVP levels were altered in both directions. Sustained AVP infusion through implantable minipumps induced a time-dependent increase in fasting glycemia, whereas lowering endogenous AVP by increasing water intake had no effect. After 4 wk of AVP infusion, the rise in glycemia amounted to 1.1 mmol/l (P < 0.01) without significant change in insulinemia. This effect was attenuated by cotreatment with a V1AR antagonist. Similar results were observed in lean Zucker rats. These findings demonstrate for the first time a causal link between chronic high AVP and hyperglycemia through V1AR activation and, thus, provide a pathophysiological explanation for the relationship observed in human cohorts between the AVP-hydration axis and the risk of diabetes.
Subject headings
- MEDICIN OCH HÄLSOVETENSKAP -- Klinisk medicin -- Annan klinisk medicin (hsv//swe)
- MEDICAL AND HEALTH SCIENCES -- Clinical Medicine -- Other Clinical Medicine (hsv//eng)
Keyword
- Glucagon
- Glycemia
- Insulin
- Vasopressin V receptor
Publication and Content Type
- art (subject category)
- ref (subject category)
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- By the author/editor
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Taveau, Christop ...
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Chollet, Catheri ...
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Bichet, Daniel G ...
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Velho, Gilberto
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Guillon, Gilles
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Corbani, Maithe
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show more...
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Roussel, Ronan
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Bankir, Lise
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Melander, Olle
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Bouby, Nadine
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- About the subject
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- MEDICAL AND HEALTH SCIENCES
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MEDICAL AND HEAL ...
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and Clinical Medicin ...
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and Other Clinical M ...
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American Journal ...
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Lund University