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Sökning: onr:"swepub:oai:DiVA.org:umu-203104" > High-risk subtypes ...

High-risk subtypes of chronic lymphocytic leukemia are detectable as early as 16 years prior to diagnosis

Kolijn, P. Martijn (författare)
Department of Immunology, Laboratory Medical Immunology, Erasmus MC, Rotterdam, Netherlands; Division of Environmental Epidemiology and Veterinary Public Health, Institute for Risk Assessment Sciences, Utrecht University, Utrecht, Netherlands,Erasmus University Medical Center
Hosnijeh, Fatemeh Saberi (författare)
Division of Environmental Epidemiology and Veterinary Public Health, Institute for Risk Assessment Sciences, Utrecht University, Utrecht, Netherlands
Späth, Florentin (författare)
Umeå University
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Hengeveld, Paul J. (författare)
Department of Immunology, Laboratory Medical Immunology, Erasmus MC, Rotterdam, Netherlands,Erasmus University Medical Center
Agathangelidis, Andreas (författare)
Institute of Applied Biosciences, Centre for Research and Technology Hellas, Thessaloniki, Greece; Department of Biology, School of Science, National and Kapodistrian University of Athens, Athens, Greece
Saleh, Manal (författare)
Division of Environmental Epidemiology and Veterinary Public Health, Institute for Risk Assessment Sciences, Utrecht University, Utrecht, Netherlands
Casabonne, Delphine (författare)
Centro de Investigación Biomédica en Red: Epidemiología y Salud Pública, Madrid, Spain; Unit of Molecular and Genetic Epidemiology in Infections and Cancer, Cancer Epidemiology Research Programme, Bellvitge Institute for Biomedical Research (IDIBELL), Catalan Institute of Oncology, Hospitalet De Llobregat, Barcelona, Spain,CIBER Epidemiology and Public Health (CIBERESP)
Benavente, Yolanda (författare)
Centro de Investigación Biomédica en Red: Epidemiología y Salud Pública, Madrid, Spain; Unit of Molecular and Genetic Epidemiology in Infections and Cancer, Cancer Epidemiology Research Programme, Bellvitge Institute for Biomedical Research (IDIBELL), Catalan Institute of Oncology, Hospitalet De Llobregat, Barcelona, Spain,CIBER Epidemiology and Public Health (CIBERESP)
Jerkeman, Mats (författare)
Lund University,Lunds universitet,Medicinsk onkologi,Sektion I,Institutionen för kliniska vetenskaper, Lund,Medicinska fakulteten,Lymfom - Klinisk forskning,Forskargrupper vid Lunds universitet,LUCC: Lunds universitets cancercentrum,Övriga starka forskningsmiljöer,Onkologi övergripande,Institutionen för kliniska vetenskaper, Lund,Medical oncology,Section I,Department of Clinical Sciences, Lund,Faculty of Medicine,Lymphoma - Clinical Research,Lund University Research Groups,LUCC: Lund University Cancer Centre,Other Strong Research Environments,Oncology corporate,Department of Clinical Sciences, Lund,Skåne University Hospital
Agudo, Antonio (författare)
Unit of Nutrition and Cancer, Epidemiology, Public Health, Cancer Prevention, and Palliative Care Program, Bellvitge Biomedical Research Institute, Bellvitge Institute for Biomedical Research (IDIBELL), Catalan Institute of Oncology, Hospitalet De Llobregat, Barcelona, Spain
Barricarte, Aurelio (författare)
Navarra Public Health Institute, Navarra Institute for Health Research, Pamplona, Spain; Biomedical Research Networking Center for Epidemiology and Public Health (CIBERESP), Madrid, Spain,Health Research Institute of Navarra (IDISNA),CIBER Epidemiology and Public Health (CIBERESP)
Besson, Caroline (författare)
Université Paris-Saclay, Université de Versailles Saint-Quentin-en-Yvelines (UVSQ), French Institute of Health and Medical Research (INSERM), Équipe “Exposome et Hérédité”, Centre de Recherche en épidémiologie et Santé des populations (CESP), Villejuif, France; Service d'Hématologie Oncologie, Centre Hospitalier de Versailles, Le Chesnay, France
Sánchez, Maria-Jose (författare)
Centro de Investigación Biomédica en Red: Epidemiología y Salud Pública, Madrid, Spain; Escuela Andaluza de Salud Pública, Instituto de Investigación Biosanitaria ibs.GRANADA, Department of Preventive Medicine and Public Health, University of Granada, Granada, Spain,CIBER Epidemiology and Public Health (CIBERESP)
Chirlaque, María-Dolores (författare)
Biomedical Research Networking Center for Epidemiology and Public Health (CIBERESP), Madrid, Spain; Department of Epidemiology, Regional Health Council, Instituto Murciano de Investigación Biosanitaria Virgen de la Arrixaca (IMIB-Arrixaca), Murcia University, Murcia, Spain,CIBER Epidemiology and Public Health (CIBERESP)
Masala, Giovanna (författare)
Epidemiology Unit, Institute for Cancer Research, Prevention and Clinical Network, Florence, Italy,Institute for Cancer Research, Prevention and Clinical Network (ISPRO)
Sacerdote, Carlotta (författare)
Unit of Cancer Epidemiology, Città della Salute e della Scienza University-Hospital, Turin, Italy
Grioni, Sara (författare)
Epidemiology and Prevention Unit, Fondazione Istituto di Ricovero e Cura a Carattere Scientifico (IRCCS) Istituto Nazionale dei Tumori di Milano, Milano, Italy
Schulze, Matthias B. (författare)
Department of Molecular Epidemiology, German Institute of Human Nutrition Potsdam-Rehbruecke, Nuthetal, Germany; Institute of Nutritional Science, University of Potsdam, Potsdam, Germany
Nieters, Alexandra (författare)
Institute for Immunodeficiency, University Medical Center Freiburg, Freiburg, Germany
Engelfriet, Peter (författare)
National Institute for Public Health and the Environment, Bilthoven, Netherlands,National Institute for Public Health and the Environment (RIVM)
Hultdin, Magnus (författare)
Umeå University,Umeå universitet,Patologi
McKay, James D. (författare)
Genomic Epidemiology Branch, International Agency for Research on Cancer, Lyon, France,International Agency for Research on Cancer, World Health Organization
Vermeulen, Roel C.H. (författare)
Division of Environmental Epidemiology and Veterinary Public Health, Institute for Risk Assessment Sciences, Utrecht University, Utrecht, Netherlands
Langerak, Anton W. (författare)
Department of Immunology, Laboratory Medical Immunology, Erasmus MC, Rotterdam, Netherlands,Erasmus University Medical Center
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 (creator_code:org_t)
American Society of Hematology, 2022
2022
Engelska.
Ingår i: Blood. - : American Society of Hematology. - 0006-4971 .- 1528-0020. ; 139:10, s. 1557-1563
Relaterad länk:
https://doi.org/10.1...
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https://umu.diva-por... (primary) (Raw object)
http://dx.doi.org/10... (free)
https://urn.kb.se/re...
https://doi.org/10.1...
https://lup.lub.lu.s...
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  • Tidskriftsartikel (refereegranskat)
Abstract Ämnesord
Stäng  
  • Chronic lymphocytic leukemia (CLL) is preceded by monoclonal B-cell lymphocytosis (MBL), a CLL precursor state with a prevalence of up to 12% in aged individuals; however, the duration of MBL and the mechanisms of its evolution to CLL remain largely unknown. In this study, we sequenced the B-cell receptor (BcR) immunoglobulin heavy chain (IGH) gene repertoire of 124 patients with CLL and 118 matched controls in blood samples taken up to 22 years prior to diagnosis. Significant skewing in the BcR IGH gene repertoire was detected in the majority of patients, even before the occurrence of lymphocytosis and irrespective of the clonotypic IGH variable gene somatic hypermutation status. Furthermore, we identified dominant clonotypes belonging to major stereotyped subsets associated with poor prognosis up to 16 years before diagnosis in 14 patients with CLL. In 22 patients with longitudinal samples, the skewing of the BcR IGH gene repertoire increased significantly over time to diagnosis or remained stable at high levels. For 14 of 16 patients with available samples at diagnosis, the CLL clonotype was already present in the prediagnostic samples. Overall, our data indicate that the preclinical phase of CLL could be longer than previously thought, even in adverse-prognostic cases.

Ämnesord

MEDICIN OCH HÄLSOVETENSKAP  -- Klinisk medicin -- Hematologi (hsv//swe)
MEDICAL AND HEALTH SCIENCES  -- Clinical Medicine -- Hematology (hsv//eng)
MEDICIN OCH HÄLSOVETENSKAP  -- Klinisk medicin -- Cancer och onkologi (hsv//swe)
MEDICAL AND HEALTH SCIENCES  -- Clinical Medicine -- Cancer and Oncology (hsv//eng)

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