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Re-evaluation of cl...
Re-evaluation of clinical dementia diagnoses with PET-PIB
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Degerman Gunnarsson, Malin (författare)
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Lindau, Maria (författare)
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Santillo, Alexander (författare)
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visa fler...
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- Wall, Anders (författare)
- Uppsala universitet,Enheten för nuklearmedicin och PET
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Engler, Henry (författare)
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Lannfelt, Lars (författare)
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Basun, Hans (författare)
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Kilander, Lena (författare)
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visa färre...
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(creator_code:org_t)
- Engelska.
- Relaterad länk:
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https://urn.kb.se/re...
Abstract
Ämnesord
Stäng
- Objectives: There is an overlap regarding Pittsburgh Compound-B (PIB) retention in patients clinically diagnosed as Alzheimer’s disease (AD) and non-AD dementia. The aim of the present study was to investigate whether there are any differences between PIB+ and PIB PIB- patients in a mixed cohort of patients with neurodegenerative dementia of mild severity regarding neuropsychological test performance and regional cerebral glucose metabolism measured with 18 Fluoro-2-deoxy-d-glucose (FDG) PET.Methods: Eighteen patients clinically diagnosed as probable AD or frontotemporal dementia were examined with PIB PET, FDG PET and neuropsychological tests and followed for 5-9 years in a clinical setting.Results: The PIB+ patients (7/18) had slower psychomotor speed and more impaired visual episodic memory than the PIB- patients, otherwise performance did not differ between groups. The initial clinical diagnoses were changed in one third of the patients (6/18) during follow-up. Conclusions: The subtle differences in neuropsychological performance, the overlap of hypometabolic patterns and clinical features between AD and non-AD dementia highlight the need of amyloid biomarkers and readiness to re-evaluate the initial diagnosis.
Nyckelord
- Alzheimer’s disease
- PIB PET
- Dementia with Lewy Bodies
- Frontotemporal dementia
- ß-amyloid
- amyloid biomarker
- FDG PET
- neuropsychological tests
- TMT A
- episodic memory
- Medicinsk vetenskap
- Medical Science
Publikations- och innehållstyp
- vet (ämneskategori)
- ovr (ämneskategori)