Sökning: WFRF:(Sarkisyan Daniil) >
Coordinated express...
Coordinated expression of the renin-angiotensin genes in the lumbar spinal cord : Lateralization and effects of unilateral brain injury
-
- Bakalkin, Georgy (författare)
- Uppsala universitet,Institutionen för farmaceutisk biovetenskap
-
- Kahle, Anika (författare)
- Uppsala universitet,Institutionen för farmaceutisk biovetenskap
-
- Sarkisyan, Daniil (författare)
- Uppsala universitet,Institutionen för farmaceutisk biovetenskap
-
visa fler...
-
- Watanabe, Hiroyuki (författare)
- Uppsala universitet,Institutionen för farmaceutisk biovetenskap
-
- Lukoyanov, Nikolay (författare)
- Univ Porto, Fac Med, Dept Biomed, Porto, Portugal.;Univ Porto, Inst Invest Inovacao Saude, Porto, Portugal.;Univ Porto, Inst Biol Mol & Celular, Porto, Portugal.
-
- Carvalho, Liliana S. (författare)
- Univ Porto, Fac Med, Dept Biomed, Porto, Portugal.;Univ Porto, Inst Invest Inovacao Saude, Porto, Portugal.;Univ Porto, Inst Biol Mol & Celular, Porto, Portugal.
-
- Galatenko, Vladimir (författare)
- Lomonosov Moscow State Univ, Fac Mech & Math, Moscow, Russia.;Evotec Int GmbH, Gottingen, Germany.
-
- Hallberg, Mathias, 1971- (författare)
- Uppsala universitet,Institutionen för farmaceutisk biovetenskap
-
- Nosova, Olga (författare)
- Uppsala universitet,Institutionen för farmaceutisk biovetenskap
-
visa färre...
-
(creator_code:org_t)
- 2021-07-16
- 2021
- Engelska.
-
Ingår i: European Journal of Neuroscience. - : John Wiley & Sons. - 0953-816X .- 1460-9568. ; 54:4, s. 5560-5573
- Relaterad länk:
-
https://doi.org/10.1...
-
visa fler...
-
https://uu.diva-port... (primary) (Raw object)
-
https://onlinelibrar...
-
https://urn.kb.se/re...
-
https://doi.org/10.1...
-
visa färre...
Abstract
Ämnesord
Stäng
- In spite of its apparent symmetry, the spinal cord is asymmetric in its reflexes and gene expression patterns including leftward expression bias of the opioid and glutamate genes. To examine whether this is a general phenomenon for neurotransmitter and neurohormonal genes, we here characterized expression and co-expression (transcriptionally coordinated) patterns of genes of the renin-angiotensin system (RAS) that is involved in neuroprotection and pathological neuroplasticity in the left and right lumbar spinal cord. We also tested whether the RAS expression patterns were affected by unilateral brain injury (UBI) that rewired lumbar spinal neurocircuits. The left and right halves of the lumbar spinal cord were analysed in intact rats, and rats with left- or right-sided unilateral cortical injury, and left- or right-sided sham surgery. The findings were (i) lateralized expression of the RAS genes Ace, Agtr2 and Ren with higher levels on the left side; (ii) the asymmetry in coordination of the RAS gene expression that was stronger on the right side; (iii) the decay in coordination of co-expression of the RAS and neuroplasticity-related genes induced by the right-side but not left-side sham surgery and UBI; and (iv) the UBI-induced shift to negative regulatory interactions between RAS and neuroplasticity-related genes on the contralesional spinal side. Thus, the RAS genes may be a part of lateralized gene co-expression networks and have a role in a side-specific regulation of spinal neurocircuits.
Ämnesord
- MEDICIN OCH HÄLSOVETENSKAP -- Medicinska och farmaceutiska grundvetenskaper -- Neurovetenskaper (hsv//swe)
- MEDICAL AND HEALTH SCIENCES -- Basic Medicine -- Neurosciences (hsv//eng)
Nyckelord
- brain injury
- co-expression patterns
- gene expression
- neuroplasticity
- renin-angiotensin system
- spinal cord
Publikations- och innehållstyp
- ref (ämneskategori)
- art (ämneskategori)
Hitta via bibliotek
Till lärosätets databas