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Sökning: onr:"swepub:oai:DiVA.org:uu-375819" > Donor Experiences o...

Donor Experiences of Second Marrow or Peripheral Blood Stem Cell Collection Mirror the First, but CD34+ Yields Are Less

Stroncek, David F (författare)
Department of Transfusion Medicine, Cell Processing Section, Clinical Center, National Institutes of Health, Bethesda, Maryland
Shaw, Bronwen E (författare)
Center for International Blood and Bone Marrow Transplant Research, Medical College of Wisconsin, Milwaukee, Wisconsin
Logan, Brent R (författare)
Center for International Blood and Bone Marrow Transplant Research, Medical College of Wisconsin, Milwaukee, Wisconsin
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Kiefer, Deidre M (författare)
Center for International Blood and Bone Marrow Transplant Research, National Marrow Donor Program, Minneapolis, Minnesota
Savani, Bipin N (författare)
Hematology & Stem Cell Transplantation, Vanderbilt University Medical Center, Nashville, Tennessee
Anderlini, Paolo (författare)
Stem Cell Transplantation and Cellular Therapy, The University of Texas M.D. Anderson Cancer Center, Houston, Texas
Bredeson, Christopher N (författare)
The Ottawa Hospital Blood & Marrow Transplant Program, University of Ottawa, Ottawa, Ontario, Canada
Hematti, Peiman (författare)
Department of Medicine, University of Wisconsin, Madison, Wisconsin
Ganguly, Siddhartha (författare)
Hematologic Malignancies and Cellular Therapies, University of Kansas Medical Center, Westwood, Kansas
Diaz, Miguel Angel (författare)
Unidad de Trasplante Hematopoyetico, Hospital Infantil Universitario Niño Jesús, Madrid, Spain
Abdel-Azim, Hisham (författare)
Department of Pediatrics, Children's Hospital Los Angeles, Los Angeles, California
Ahmed, Ibrahim (författare)
Children's Mercy Hospital—UMKC, Kansas City, Missouri
Maharaj, Dipnarine (författare)
South Florida Bone Marrow Transplant/Stem Cell Transplant Institute, Bethesda Health City, Boynton Beach, Florida
Seftel, Matthew (författare)
Medical Oncology and Haematology, CancerCare Manitoba, Winnipeg, Ontario, Canada
Beitinjaneh, Amer (författare)
Stem Cell Transplantation and Cell Therapy Program, Miller School of Medicine, University of Miami, Miami, Florida
Seo, Sachiko (författare)
Vaccine and Infectious Disease Division, Fred Hutchinson Cancer Research Center, Seattle, Washington
Yared, Jean A (författare)
Department of Medicine, Greenbaum Cancer Center, University of Maryland, Baltimore, Maryland
Halter, Joerg (författare)
Department of Haematology, University Hospital Basel, Basel, Switzerland
O'Donnell, Paul V (författare)
Blood and Marrow Transplant Program, Massachusetts General Hospital, Harvard Medical School, Boston, Massachusetts
Hale, Gregory A (författare)
Cancer and Blood Disorders Institute, All Children's Hospital, St. Petersburg, Florida
DeFilipp, Zachariah (författare)
Blood and Marrow Transplant Program, Massachusetts General Hospital, Harvard Medical School, Boston, Massachusetts
Lazarus, Hillard (författare)
Department of Medicine, University Hospitals Case Medical Center, Case Western Reserve University, Cleveland, Ohio
Liesveld, Jane L (författare)
Hematology-Oncology Unit, Department of Medicine, Strong Memorial Hospital, University of Rochester Medical Center, Rochester, New York
Zhou, Zheng (författare)
University of Massachusetts, Marlboro, Massachusetts
Munshi, Pashna (författare)
Georgetown University Hospital, Washington, District of Columbia
Olsson, Richard F. (författare)
Karolinska Institutet
Kasow, Kimberly Anne (författare)
Division of Hematology-Oncology, Department of Pediatrics, University of North Carolina at Chapel Hill, Chapel Hill, North Carolina
Szer, Jeffrey (författare)
Department of Hematology and Bone Marrow Transplantation, Royal Melbourne Hospital City Campus, Victoria, Australia
Switzer, Galen E (författare)
Department of Medicine, University of Pittsburgh, Pittsburgh, Pennsylvania
Chitphakdithai, Pintip (författare)
Center for International Blood and Bone Marrow Transplant Research, National Marrow Donor Program, Minneapolis, Minnesota
Shah, Nirali (författare)
Pediatric Oncology Branch, National Cancer Institute, National Institutes of Health, Bethesda, Maryland
Confer, Dennis L (författare)
Center for International Blood and Bone Marrow Transplant Research, National Marrow Donor Program, Minneapolis, Minnesota
Pulsipher, Michael A (författare)
Department of Pediatrics, Children's Hospital Los Angeles, Los Angeles, California
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 (creator_code:org_t)
Elsevier BV, 2018
2018
Engelska.
Ingår i: Biology of blood and marrow transplantation. - : Elsevier BV. - 1083-8791 .- 1523-6536. ; 24:1, s. 175-184
Relaterad länk:
https://doi.org/10.1...
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http://www.bbmt.org/...
https://urn.kb.se/re...
https://doi.org/10.1...
http://kipublication...
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  • Tidskriftsartikel (refereegranskat)
Abstract Ämnesord
Stäng  
  • Little is known about the experiences of individuals donating peripheral blood stem cells (PBSCs) or marrow for a second time. To study this, unrelated donors making a second donation through the National Marrow Donor Program between 2004 and 2013 were evaluated. Experiences of second-time donors giving marrow (n = 118: first donation was PBSC in 76 and marrow in 42) were compared with those making only 1 marrow donation (n = 5829). Experiences of second-time donors giving PBSCs (n = 602) (first donation was PBSCs in 362; marrow in 240) were compared to first-time PBSC donors (n = 16,095). For donors giving a second PBSC or marrow donation there were no significant differences in maximum skeletal pain, maximum symptoms measured by an established modified toxicity criteria, and recovery time compared with those who donated only once. Notably, the yield of marrow nucleated cells and PBSC CD34+ cells with second donations was less. As previously noted with single first-time donations, female (PBSCs and marrow) and obese donors (PBSCs) had higher skeletal pain and/or toxicity with a second donation. PBSC donors who experienced high levels of pain or toxicity with the first donation also experienced high levels of these symptoms with their second donation and slower recovery times. In conclusion, for most donors second donation experiences were similar to first donation experiences, but CD34+ yields were less. Knowledge of the donor's first experience and stem cell yields may help centers decide whether second donations are appropriate and institute measures to improve donor experiences.

Ämnesord

MEDICIN OCH HÄLSOVETENSKAP  -- Klinisk medicin -- Hematologi (hsv//swe)
MEDICAL AND HEALTH SCIENCES  -- Clinical Medicine -- Hematology (hsv//eng)
MEDICIN OCH HÄLSOVETENSKAP  -- Medicinska och farmaceutiska grundvetenskaper -- Immunologi inom det medicinska området (hsv//swe)
MEDICAL AND HEALTH SCIENCES  -- Basic Medicine -- Immunology in the medical area (hsv//eng)

Nyckelord

Bone marrow
Hematopoietic cell transplantation
Peripheral blood stem cells
Unrelated donor

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