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Mendelian randomization implies no direct causal association between leukocyte telomere length and amyotrophic lateral sclerosis
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- Gao, YX (author)
- Xuzhou Medical University
-
- LANDQVIST WALDÖ, MARIA (author)
- Lund University,Lunds universitet,Kliniska Vetenskaper, Helsingborg,Sektion II,Institutionen för kliniska vetenskaper, Lund,Medicinska fakulteten,Psykiatri, Lund,Sektion IV,Institutionen för kliniska vetenskaper, Lund,Clinical Sciences, Helsingborg,Section II,Department of Clinical Sciences, Lund,Faculty of Medicine,Psychiatry (Lund),Section IV,Department of Clinical Sciences, Lund
- Yu, XH (author)
- show more...
- Zhao, HS (author)
- Ferrari, R (author)
- Hernandez, DG (author)
- Nails, MA (author)
- Rohrers, JD (author)
- Ramasamys, A (author)
- Kwok, JBJ (author)
- Dobson-Stone, C (author)
- Brooks, WS (author)
- Schofield, PR (author)
- Halliday, GM (author)
- Hodges, JR (author)
- Piguet, O (author)
- Bartley, L (author)
- Thompson, E (author)
- Haan, E (author)
- Hernandez, I (author)
- Ruiz, A (author)
- Boada, M (author)
- Borronils, B (author)
- Padovani, A (author)
- Cruchaga, C (author)
- Cairns, NJ (author)
- Benussi, L (author)
- Binetti, G (author)
- Ghidoni, R (author)
- Forloni, G (author)
- Albani, D (author)
- Galimberti, D (author)
- Fenoglio, C (author)
- Serpente, M (author)
- Scarpini, E (author)
- Clarim, J (author)
- Lie, A (author)
- Blesa, R (author)
- Waldo, ML (author)
- Mackenzie, IRA (author)
- Hsiung, GYR (author)
- Mann, DMA (author)
- Grafman, J (author)
- Morris, CM (author)
- Attems, J (author)
- Griffiths, TD (author)
- McKeith, IG (author)
- Thomas, AJ (author)
- Pietrini, P (author)
- Huey, ED (author)
- Wassermann, EM (author)
- Baborie, A (author)
- Jaros, E (author)
- Tierney, MC (author)
- Pastor, P (author)
- Razquin, C (author)
- Ortega-Cubero, S (author)
- Alonso, E (author)
- Perneczky, R (author)
- Diehl-Schmid, J (author)
- Alexopoulos, P (author)
- Kurz, A (author)
- Rainero, I (author)
- Rubino, E (author)
- Pinessi, L (author)
- Rogaeva, E (author)
- St George-Hyslop, P (author)
- Rossi, G (author)
- Tagliavini, F (author)
- Giacconen, G (author)
- Rowe, JB (author)
- Schlachetzki, JCM (author)
- Uphill, J (author)
- Collinge, J (author)
- Mead, S (author)
- Danek, A (author)
- Van Deerlin, VM (author)
- Grossman, M (author)
- Trojanowski, JQ (author)
- van der Zee, J (author)
- Cruts, M (author)
- Van Broeckhoven, C (author)
- Cappa, SF (author)
- Leber, I (author)
- Hannequin, D (author)
- Golfier, V (author)
- Vercelletto, M (author)
- Brice, A (author)
- Nacmias, B (author)
- Sorbi, S (author)
- Bagnoli, S (author)
- Piaceri, I (author)
- Nielsen, JE (author)
- Hjermind, LE (author)
- Riemenschneider, M (author)
- Mayhaus, M (author)
- Ibach, B (author)
- Gasparoni, G (author)
- Pichler, S (author)
- Gu, W (author)
- Rossor, MN (author)
- Fox, NC (author)
- Warren, JD (author)
- Spillantini, MG (author)
- Morris, HR (author)
- Rizzu, P (author)
- Heutink, P (author)
- Snowden, JS (author)
- Rollinson, S (author)
- Richardson, A (author)
- Gerhard, A (author)
- Bruni, AC (author)
- Maletta, R (author)
- Frangipane, F (author)
- Cupidi, C (author)
- Bernardi, L (author)
- Anfossi, M (author)
- Gallo, M (author)
- Conidi, ME (author)
- Smirne, N (author)
- Rademakers, R (author)
- Baker, M (author)
- Dickson, DW (author)
- Graff-Radford, NR (author)
- Petersen, RC (author)
- Knopman, D (author)
- Josephs, KA (author)
- Boeve, BF (author)
- Parisi, JE (author)
- Seeley, WW (author)
- Miller, BL (author)
- Karydas, AM (author)
- Rosen, H (author)
- van Swieten, JC (author)
- Dopper, EGP (author)
- Seelaar, H (author)
- Pijnenburg, YAL (author)
- Scheltens, P (author)
- Logroscino, G (author)
- Capozzo, R (author)
- Novelli, V (author)
- Puca, AA (author)
- Franceschi, M (author)
- Postiglione, A (author)
- Milan, G (author)
- Sorrentino, P (author)
- Kristiansen, M (author)
- Huei-Hsin, G (author)
- Graff, CC (author)
- Pasquier, F (author)
- Rollin, A (author)
- Deramecourt, V (author)
- Lebouvier, T (author)
- Ferrucci, L (author)
- Pickering-Brown, S (author)
- Singleton, AB (author)
- Hardy, J (author)
- Momeni, P (author)
- show less...
- (creator_code:org_t)
- 2020-07-22
- 2020
- English.
- In: Scientific reports. - : Springer Science and Business Media LLC. - 2045-2322. ; 10:1, s. 12184-
- Journal article (peer-reviewed)
Abstract
Subject headings
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- We employed Mendelian randomization (MR) to evaluate the causal relationship between leukocyte telomere length (LTL) and amyotrophic lateral sclerosis (ALS) with summary statistics from genome-wide association studies (n = ~ 38,000 for LTL and ~ 81,000 for ALS in the European population; n = ~ 23,000 for LTL and ~ 4,100 for ALS in the Asian population). We further evaluated mediation roles of lipids in the pathway from LTL to ALS. The odds ratio per standard deviation decrease of LTL on ALS was 1.10 (95% CI 0.93–1.31, p = 0.274) in the European population and 0.75 (95% CI 0.53–1.07, p = 0.116) in the Asian population. This null association was also detected between LTL and frontotemporal dementia in the European population. However, we found that an indirect effect of LTL on ALS might be mediated by low density lipoprotein (LDL) or total cholesterol (TC) in the European population. These results were robust against extensive sensitivity analyses. Overall, our MR study did not support the direct causal association between LTL and the ALS risk in neither population, but provided suggestive evidence for the mediation role of LDL or TC on the influence of LTL and ALS in the European population.
Subject headings
- MEDICIN OCH HÄLSOVETENSKAP -- Medicinska och farmaceutiska grundvetenskaper -- Medicinsk genetik (hsv//swe)
- MEDICAL AND HEALTH SCIENCES -- Basic Medicine -- Medical Genetics (hsv//eng)
- MEDICIN OCH HÄLSOVETENSKAP -- Medicinska och farmaceutiska grundvetenskaper -- Neurovetenskaper (hsv//swe)
- MEDICAL AND HEALTH SCIENCES -- Basic Medicine -- Neurosciences (hsv//eng)
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- ref (subject category)
- art (subject category)
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- Gao, YX
- LANDQVIST WALDÖ, ...
- Yu, XH
- Zhao, HS
- Zeng, P
- Ferrari, R
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- Hernandez, DG
- Nails, MA
- Rohrers, JD
- Ramasamys, A
- Kwok, JBJ
- Dobson-Stone, C
- Brooks, WS
- Schofield, PR
- Halliday, GM
- Hodges, JR
- Piguet, O
- Bartley, L
- Thompson, E
- Haan, E
- Hernandez, I
- Ruiz, A
- Boada, M
- Borronils, B
- Padovani, A
- Cruchaga, C
- Cairns, NJ
- Benussi, L
- Binetti, G
- Ghidoni, R
- Forloni, G
- Albani, D
- Galimberti, D
- Fenoglio, C
- Serpente, M
- Scarpini, E
- Clarim, J
- Lie, A
- Blesa, R
- Waldo, ML
- Nilsson, Karin
- Nilsson, Christe ...
- Mackenzie, IRA
- Hsiung, GYR
- Mann, DMA
- Grafman, J
- Morris, CM
- Attems, J
- Griffiths, TD
- McKeith, IG
- Thomas, AJ
- Pietrini, P
- Huey, ED
- Wassermann, EM
- Baborie, A
- Jaros, E
- Tierney, MC
- Pastor, P
- Razquin, C
- Ortega-Cubero, S
- Alonso, E
- Perneczky, R
- Diehl-Schmid, J
- Alexopoulos, P
- Kurz, A
- Rainero, I
- Rubino, E
- Pinessi, L
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- Rossi, G
- Tagliavini, F
- Giacconen, G
- Rowe, JB
- Schlachetzki, JC ...
- Uphill, J
- Collinge, J
- Mead, S
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- Van Deerlin, VM
- Grossman, M
- Trojanowski, JQ
- van der Zee, J
- Cruts, M
- Van Broeckhoven, ...
- Cappa, SF
- Leber, I
- Hannequin, D
- Golfier, V
- Vercelletto, M
- Brice, A
- Nacmias, B
- Sorbi, S
- Bagnoli, S
- Piaceri, I
- Nielsen, JE
- Hjermind, LE
- Riemenschneider, ...
- Mayhaus, M
- Ibach, B
- Gasparoni, G
- Pichler, S
- Gu, W
- Rossor, MN
- Fox, NC
- Warren, JD
- Spillantini, MG
- Morris, HR
- Rizzu, P
- Heutink, P
- Snowden, JS
- Rollinson, S
- Richardson, A
- Gerhard, A
- Bruni, AC
- Maletta, R
- Frangipane, F
- Cupidi, C
- Bernardi, L
- Anfossi, M
- Gallo, M
- Conidi, ME
- Smirne, N
- Rademakers, R
- Baker, M
- Dickson, DW
- Graff-Radford, N ...
- Petersen, RC
- Knopman, D
- Josephs, KA
- Boeve, BF
- Parisi, JE
- Seeley, WW
- Miller, BL
- Karydas, AM
- Rosen, H
- van Swieten, JC
- Dopper, EGP
- Seelaar, H
- Pijnenburg, YAL
- Scheltens, P
- Logroscino, G
- Capozzo, R
- Novelli, V
- Puca, AA
- Franceschi, M
- Postiglione, A
- Milan, G
- Sorrentino, P
- Kristiansen, M
- Huei-Hsin, G
- Graff, CC
- Pasquier, F
- Rollin, A
- Deramecourt, V
- Lebouvier, T
- Ferrucci, L
- Pickering-Brown, ...
- Singleton, AB
- Hardy, J
- Momeni, P
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- and Medical Genetics
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- MEDICAL AND HEALTH SCIENCES
- MEDICAL AND HEAL ...
- and Basic Medicine
- and Neurosciences
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- Karolinska Institutet
- Lund University
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