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Alcohol consumption, cardiac biomarkers, and risk of atrial fibrillation and adverse outcomes

Csengeri, Dora (författare)
Department of Cardiology, University Heart & Vascular Center Hamburg, Hamburg, Germany
Sprünker, Ngoc-Anh (författare)
Department of Cardiology, University Heart & Vascular Center Hamburg, Hamburg, Germany
Niiranen, Teemu (författare)
Division of Medicine, Turku University Hospital and University of Turku, Turku, Finland; Department of Public Health Solutions, Finnish Institute for Health and Welfare, Helsinki, Finland
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Vishram-Nielsen, Julie Kk. (författare)
Center for Clinical Research and Prevention, Bispebjerg and Frederiksberg Hospital, Capital Region of Denmark, Frederiksberg, Denmark; Department of Cardiology, Righospitalet, University Hospital of Copenhagen, Copenhagen, Denmark
Costanzo, Simona (författare)
Department of Epidemiology and Prevention, IRCCS Neuromed, Pozzilli, Italy
Söderberg, Stefan (författare)
Umeå universitet,Avdelningen för medicin
Jensen, Steen M. (författare)
Umeå universitet,Avdelningen för medicin
Vartiainen, Erkki (författare)
Department of Public Health Solutions, Finnish Institute for Health and Welfare, Helsinki, Finland
Donati, Maria Benedetta (författare)
Department of Epidemiology and Prevention, IRCCS Neuromed, Pozzilli, Italy
Magnussen, Christina (författare)
Department of Cardiology, University Heart & Vascular Center Hamburg, Hamburg, Germany; German Centre for Cardiovascular Research (DZHK), Berlin, Germany
Camen, Stephan (författare)
Department of Cardiology, University Heart & Vascular Center Hamburg, Hamburg, Germany; German Centre for Cardiovascular Research (DZHK), Berlin, Germany
Gianfagna, Francesco (författare)
Research Center in Epidemiology and Preventive Medicine (EPIMED), Department of Medicine and Surgery, University of Insubria, Varese, Italy
Løchen, Maja-Lisa (författare)
Department of Community Medicine, UiT The Arctic University of Norway, Norway
Kee, Frank (författare)
Center for Public Health, Institute of Clinical Sciences A, Queens University, Belfast, Ireland
Kontto, Jukka (författare)
Department of Public Health Solutions, Finnish Institute for Health and Welfare, Helsinki, Finland
Mathiesen, Ellisiv B. (författare)
Brain and Circulation Research Group, Department of Clinical Medicine, UiT The Arctic University of Norway, Norway
Koenig, Wolfgang (författare)
Deutsches Herzzentrum München, Munich, Germany; DZHK (German Centre for Cardiovascular Research), partner site Munich Heart Alliance, Munich, Germany; Institute of Epidemiology and Medial Biometry, University of Ulm, Ulm, Germany
Stefan, Blankenberg (författare)
Department of Cardiology, University Heart & Vascular Center Hamburg, Hamburg, Germany; German Centre for Cardiovascular Research (DZHK), Berlin, Germany
de Gaetano, Giovanni (författare)
Department of Epidemiology and Prevention, IRCCS Neuromed, Pozzilli, Italy
Jørgensen, Torben (författare)
Center for Clinical Research and Prevention, Bispebjerg and Frederiksberg Hospital, Capital Region of Denmark, Frederiksberg, Denmark; Department of Public Health, Faculty of Health and Medical Science, University of Copenhagen, Copenhagen, Denmark; Faculty of Medicine, Aalborg University, Aalborg, Denmark
Kuulasmaa, Kari (författare)
Department of Public Health Solutions, Finnish Institute for Health and Welfare, Helsinki, Finland
Zeller, Tanja (författare)
Department of Cardiology, University Heart & Vascular Center Hamburg, Hamburg, Germany
Salomaa, Veikko (författare)
Department of Public Health Solutions, Finnish Institute for Health and Welfare, Helsinki, Finland
Iacoviello, Licia (författare)
Department of Epidemiology and Prevention, IRCCS Neuromed, Pozzilli, Italy; Research Center in Epidemiology and Preventive Medicine (EPIMED), Department of Medicine and Surgery, University of Insubria, Varese, Italy
Schnabel, Renate B. (författare)
Department of Cardiology, University Heart & Vascular Center Hamburg, Hamburg, Germany; German Centre for Cardiovascular Research (DZHK), Berlin, Germany
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 (creator_code:org_t)
2021-01-13
2021
Engelska.
Ingår i: European Heart Journal. - : Oxford University Press. - 0195-668X .- 1522-9645. ; 42:12, s. 1170-1177
  • Tidskriftsartikel (refereegranskat)
Abstract Ämnesord
Stäng  
  • AIMS: There is inconsistent evidence on the relation of alcohol intake with incident atrial fibrillation (AF), in particular at lower doses. We assessed the association between alcohol consumption, biomarkers, and incident AF across the spectrum of alcohol intake in European cohorts.METHODS AND RESULTS: In a community-based pooled cohort, we followed 107 845 individuals for the association between alcohol consumption, including types of alcohol and drinking patterns, and incident AF. We collected information on classical cardiovascular risk factors and incident heart failure (HF) and measured the biomarkers N-terminal pro-B-type natriuretic peptide and high-sensitivity troponin I. The median age of individuals was 47.8 years, 48.3% were men. The median alcohol consumption was 3 g/day. N = 5854 individuals developed AF (median follow-up time: 13.9 years). In a sex- and cohort-stratified Cox regression analysis alcohol consumption was non-linearly and positively associated with incident AF. The hazard ratio for one drink (12 g) per day was 1.16, 95% CI 1.11-1.22, P < 0.001. Associations were similar across types of alcohol. In contrast, alcohol consumption at lower doses was associated with reduced risk of incident HF. The association between alcohol consumption and incident AF was neither fully explained by cardiac biomarker concentrations nor by the occurrence of HF.CONCLUSIONS: In contrast to other cardiovascular diseases such as HF, even modest habitual alcohol intake of 1.2 drinks/day was associated with an increased risk of AF, which needs to be considered in AF prevention.

Ämnesord

MEDICIN OCH HÄLSOVETENSKAP  -- Klinisk medicin -- Kardiologi (hsv//swe)
MEDICAL AND HEALTH SCIENCES  -- Clinical Medicine -- Cardiac and Cardiovascular Systems (hsv//eng)

Nyckelord

Alcohol consumption
Atrial fibrillation
Biomarkers
Epidemiology

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