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A genome-wide association study identifies a novel susceptibility locus for renal cell carcinoma on 12p11.23

Wu, Xifeng (author)
Scelo, Ghislaine (author)
Purdue, Mark P. (author)
show more...
Rothman, Nathaniel (author)
Johansson, Mattias (author)
International Agency for Research on Cancer (IARC), Lyon, France
Ye, Yuanqing (author)
Wang, Zhaoming (author)
Zelenika, Diana (author)
Moore, Lee E. (author)
Wood, Christopher G. (author)
Prokhortchouk, Egor (author)
Gaborieau, Valerie (author)
Jacobs, Kevin B. (author)
Chow, Wong-Ho (author)
Toro, Jorge R. (author)
Zaridze, David (author)
Lin, Jie (author)
Lubinski, Jan (author)
Trubicka, Joanna (author)
Szeszenia-Dabrowska, Neonilia (author)
Lissowska, Jolanta (author)
Rudnai, Peter (author)
Fabianova, Eleonora (author)
Mates, Dana (author)
Jinga, Viorel (author)
Bencko, Vladimir (author)
Slamova, Alena (author)
Holcatova, Ivana (author)
Navratilova, Marie (author)
Janout, Vladimir (author)
Boffetta, Paolo (author)
Colt, Joanne S. (author)
Davis, Faith G. (author)
Schwartz, Kendra L. (author)
Banks, Rosamonde E. (author)
Selby, Peter J. (author)
Harnden, Patricia (author)
Berg, Christine D. (author)
Hsing, Ann W. (author)
Grubb, Robert L., III (author)
Boeing, Heiner (author)
Vineis, Paolo (author)
Clavel-Chapelon, Francoise (author)
Palli, Domenico (author)
Tumino, Rosario (author)
Krogh, Vittorio (author)
Panico, Salvatore (author)
Duell, Eric J. (author)
Ramon Quiros, Jose (author)
Sanchez, Maria-Jose (author)
Navarro, Carmen (author)
Ardanaz, Eva (author)
Dorronsoro, Miren (author)
Khaw, Kay-Tee (author)
Allen, Naomi E. (author)
Bueno-de-Mesquita, H. Bas (author)
Peeters, Petra H. M. (author)
Trichopoulos, Dimitrios (author)
Linseisen, Jakob (author)
Ljungberg, Börje (author)
Umeå universitet,Urologi och andrologi
Overvad, Kim (author)
Tjonneland, Anne (author)
Romieu, Isabelle (author)
Riboli, Elio (author)
Stevens, Victoria L. (author)
Thun, Michael J. (author)
Diver, W. Ryan (author)
Gapstur, Susan M. (author)
Pharoah, Paul D. (author)
Easton, Douglas F. (author)
Albanes, Demetrius (author)
Virtamo, Jarmo (author)
Vatten, Lars (author)
Hveem, Kristian (author)
Fletcher, Tony (author)
Koppova, Kvetoslava (author)
Cussenot, Olivier (author)
Cancel-Tassin, Geraldine (author)
Benhamou, Simone (author)
Hildebrandt, Michelle A. (author)
Pu, Xia (author)
Foglio, Mario (author)
Lechner, Doris (author)
Hutchinson, Amy (author)
Yeager, Meredith (author)
Fraumeni, Joseph F., Jr. (author)
Lathrop, Mark (author)
Skryabin, Konstantin G. (author)
McKay, James D. (author)
Gu, Jian (author)
Brennan, Paul (author)
Chanock, Stephen J. (author)
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 (creator_code:org_t)
2011-10-18
2012
English.
In: Human Molecular Genetics. - : Oxford University Press (OUP). - 0964-6906 .- 1460-2083. ; 21:2, s. 456-462
  • Journal article (peer-reviewed)
Abstract Subject headings
Close  
  • Renal cell carcinoma (RCC) is the most lethal urologic cancer. Only two common susceptibility loci for RCC have been confirmed to date. To identify additional RCC common susceptibility loci, we conducted an independent genome- wide association study (GWAS). We analyzed 533 191 single nucleotide polymorphisms (SNPs) for association with RCC in 894 cases and 1516 controls of European descent recruited from MD Anderson Cancer Center in the primary scan, and validated the top 500 SNPs in silico in 3772 cases and 8505 controls of European descent involved in the only published GWAS of RCC. We identified two common variants in linkage disequilibrium, rs718314 and rs1049380 (r(2) = 0.64, D' = 0.84), in the inositol 1,4,5-triphosphate receptor, type 2 (ITPR2) gene on 12p11.23 as novel susceptibility loci for RCC (P = 8.89 x 10(-10) and P = 6.07 x 10(-9), respectively, in meta-analysis) with an allelic odds ratio of 1.19 [95% confidence interval (CI): 1.13-1.26] for rs718314 and 1.18 (95% CI: 1.12-1.25) for rs1049380. It has been recently identified that rs718314 in ITPR2 is associated with waist-hip ratio (WHR) phenotype. To our knowledge, this is the first genetic locus associated with both cancer risk and WHR.

Subject headings

MEDICIN OCH HÄLSOVETENSKAP  -- Klinisk medicin -- Urologi och njurmedicin (hsv//swe)
MEDICAL AND HEALTH SCIENCES  -- Clinical Medicine -- Urology and Nephrology (hsv//eng)
MEDICIN OCH HÄLSOVETENSKAP  -- Klinisk medicin -- Cancer och onkologi (hsv//swe)
MEDICAL AND HEALTH SCIENCES  -- Clinical Medicine -- Cancer and Oncology (hsv//eng)

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By the author/editor
Wu, Xifeng
Scelo, Ghislaine
Purdue, Mark P.
Rothman, Nathani ...
Johansson, Matti ...
Ye, Yuanqing
show more...
Wang, Zhaoming
Zelenika, Diana
Moore, Lee E.
Wood, Christophe ...
Prokhortchouk, E ...
Gaborieau, Valer ...
Jacobs, Kevin B.
Chow, Wong-Ho
Toro, Jorge R.
Zaridze, David
Lin, Jie
Lubinski, Jan
Trubicka, Joanna
Szeszenia-Dabrow ...
Lissowska, Jolan ...
Rudnai, Peter
Fabianova, Eleon ...
Mates, Dana
Jinga, Viorel
Bencko, Vladimir
Slamova, Alena
Holcatova, Ivana
Navratilova, Mar ...
Janout, Vladimir
Boffetta, Paolo
Colt, Joanne S.
Davis, Faith G.
Schwartz, Kendra ...
Banks, Rosamonde ...
Selby, Peter J.
Harnden, Patrici ...
Berg, Christine ...
Hsing, Ann W.
Grubb, Robert L. ...
Boeing, Heiner
Vineis, Paolo
Clavel-Chapelon, ...
Palli, Domenico
Tumino, Rosario
Krogh, Vittorio
Panico, Salvator ...
Duell, Eric J.
Ramon Quiros, Jo ...
Sanchez, Maria-J ...
Navarro, Carmen
Ardanaz, Eva
Dorronsoro, Mire ...
Khaw, Kay-Tee
Allen, Naomi E.
Bueno-de-Mesquit ...
Peeters, Petra H ...
Trichopoulos, Di ...
Linseisen, Jakob
Ljungberg, Börje
Overvad, Kim
Tjonneland, Anne
Romieu, Isabelle
Riboli, Elio
Stevens, Victori ...
Thun, Michael J.
Diver, W. Ryan
Gapstur, Susan M ...
Pharoah, Paul D.
Easton, Douglas ...
Albanes, Demetri ...
Virtamo, Jarmo
Vatten, Lars
Hveem, Kristian
Fletcher, Tony
Koppova, Kvetosl ...
Cussenot, Olivie ...
Cancel-Tassin, G ...
Benhamou, Simone
Hildebrandt, Mic ...
Pu, Xia
Foglio, Mario
Lechner, Doris
Hutchinson, Amy
Yeager, Meredith
Fraumeni, Joseph ...
Lathrop, Mark
Skryabin, Konsta ...
McKay, James D.
Gu, Jian
Brennan, Paul
Chanock, Stephen ...
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About the subject
MEDICAL AND HEALTH SCIENCES
MEDICAL AND HEAL ...
and Clinical Medicin ...
and Urology and Neph ...
MEDICAL AND HEALTH SCIENCES
MEDICAL AND HEAL ...
and Clinical Medicin ...
and Cancer and Oncol ...
Articles in the publication
Human Molecular ...
By the university
Umeå University

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