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Sökning: onr:"swepub:oai:DiVA.org:umu-214290" > Genetic Susceptibil...

Genetic Susceptibility to Nonalcoholic Fatty Liver Disease and Risk for Pancreatic Cancer: Mendelian Randomization

King, Sontoria D. (författare)
Mayo Clinic Graduate School of Biomedical Sciences, Mayo Clinic, FL, Jacksonville, Puerto Rico
Veliginti, Swathi (författare)
Division of Epidemiology, Department of Quantitative Health Sciences, Mayo Clinic, FL, Jacksonville, Puerto Rico
Brouwers, Martijn C G J (författare)
Division of Endocrinology and Metabolic Diseases, Department of Internal Medicine, Maastricht University Medical Center, Maastricht, Netherlands; CARIM School for Cardiovascular Diseases, Maastricht University, Maastricht, Netherlands
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Ren, Zhewen (författare)
Division of Endocrinology and Metabolic Diseases, Department of Internal Medicine, Maastricht University Medical Center, Maastricht, Netherlands; CARIM School for Cardiovascular Diseases, Maastricht University, Maastricht, Netherlands
Zheng, Wei (författare)
Division of Epidemiology, Department of Medicine, Vanderbilt Epidemiology Center, Vanderbilt-Ingram Cancer Center, Vanderbilt University School of Medicine, TN, Nashville, United States
Setiawan, Veronica W. (författare)
Department of Preventive Medicine, Keck School of Medicine, University of Southern California, CA, Los Angeles, United States
Wilkens, Lynne R. (författare)
Cancer Epidemiology Division, Population Sciences in the Pacific Program, University of Hawaii Cancer Center, University of Hawaii at Manoa, HI, Honolulu, United States
Shu, Xiao-Ou (författare)
Division of Epidemiology, Department of Medicine, Vanderbilt Epidemiology Center, Vanderbilt-Ingram Cancer Center, Vanderbilt University School of Medicine, TN, Nashville, United States
Arslan, Alan A. (författare)
Departments of Obstetrics and Gynecology, Population Health and Environmental Medicine, NYU Perlmutter Comprehensive Cancer Center, NY, United States
Beane Freeman, Laura E. (författare)
Division of Cancer Epidemiology and Genetics, NCI, NIH, MD, Bethesda, Liberia
Bracci, Paige M. (författare)
Department of Epidemiology and Biostatistics, University of California, CA, San Francisco, United States
Canzian, Federico (författare)
Genomic Epidemiology Group, German Cancer Research Center (DKFZ), Heidelberg, Germany
Du, Mengmeng (författare)
Department of Epidemiology and Biostatistics, Memorial Sloan Kettering Cancer Center, NY, United States
Gallinger, Steven J. (författare)
Hepatobiliary/Pancreatic Surgical Oncology Program, University Health Network, ON, Toronto, Canada; Lunenfeld-Tanenbaum Research Institute, Mount Sinai Hospital, ON, Toronto, Canada
Giles, Graham G. (författare)
Cancer Epidemiology and Intelligence Division, Cancer Council Victoria, VIC, Melbourne, Australia; Centre for Epidemiology and Biostatistics, Melbourne School of Population and Global Health, University of Melbourne, VIC, Australia; Department of Epidemiology and Preventive Medicine, Monash University, VIC, Melbourne, Australia
Goodman, Phyllis J. (författare)
SWOG Statistical Center, Fred Hutchinson Cancer Research Center, WA, Seattle, United States
Haiman, Christopher A. (författare)
Department of Preventive Medicine, Keck School of Medicine, University of Southern California, CA, Los Angeles, United States
Kogevinas, Manolis (författare)
Centre for Research in Environmental Epidemiology (CREAL), Barcelona, Spain
Kooperberg, Charles (författare)
Division of Public Health Sciences, Fred Hutchinson Cancer Research Center, WA, Seattle, United States
LeMarchand, Loic (författare)
Cancer Epidemiology Division, Population Sciences in the Pacific Program, University of Hawaii Cancer Center, University of Hawaii at Manoa, HI, Honolulu, United States
Neale, Rachel E. (författare)
Population Health Program, QIMR Berghofer Medical Research Institute, Brisbane, Australia
Visvanathan, Kala (författare)
Department of Epidemiology, Johns Hopkins School of Public Health, MD, Baltimore, Liberia; Department of Oncology, Sidney Kimmel Comprehensive Cancer Center, Johns Hopkins School of Medicine, MD, Baltimore, Liberia
White, Emily (författare)
Cancer Prevention Program, Fred Hutchinson Cancer Research Center, WA, Seattle, United States
Albanes, Demetrius (författare)
Division of Cancer Epidemiology and Genetics, NCI, NIH, MD, Bethesda, Liberia
Andreotti, Gabriella (författare)
Division of Cancer Epidemiology and Genetics, NCI, NIH, MD, Bethesda, Liberia
Babic, Ana (författare)
Department of Medical Oncology, Dana-Farber Cancer Institute, MA, Boston, United States
Berndt, Sonja I. (författare)
Division of Cancer Epidemiology and Genetics, NCI, NIH, MD, Bethesda, Liberia
Brais, Lauren K. (författare)
Department of Medical Oncology, Dana-Farber Cancer Institute, MA, Boston, United States
Brennan, Paul (författare)
Genomic Epidemiology Branch, International Agency for Research on Cancer (IARC/WHO), Lyon, France
Buring, Julie E. (författare)
Department of Epidemiology, Harvard T.H. Chan School of Public Health, MA, Boston, United States; Division of Preventive Medicine, Brigham and Women's Hospital, MA, Boston, United States
Rabe, Kari G. (författare)
Department of Quantitative Health Sciences, Mayo Clinic College of Medicine, MN, Rochester, United States
Bamlet, William R. (författare)
Department of Quantitative Health Sciences, Mayo Clinic College of Medicine, MN, Rochester, United States
Chanock, Stephen J. (författare)
Division of Cancer Epidemiology and Genetics, NCI, NIH, MD, Bethesda, Liberia
Fuchs, Charles S. (författare)
Yale Cancer Center, CT, New Haven, United States; Department of Medicine, Yale School of Medicine, CT, New Haven, United States; Smilow Cancer Hospital, CT, New Haven, United States
Gaziano, J Michael (författare)
Division of Preventive Medicine, Brigham and Women's Hospital, MA, Boston, United States; Boston Veteran Affairs Healthcare System, MA, Boston, United States
Giovannucci, Edward L. (författare)
Department of Epidemiology, Harvard T.H. Chan School of Public Health, MA, Boston, United States; Department of Nutrition, Harvard T.H. Chan School of Public Health, MA, Boston, United States; Channing Division of Network Medicine, Brigham and Women's Hospital and Harvard Medical School, MA, Boston, United States
Hackert, Thilo (författare)
Department of General, Visceral and Transplantation Surgery, University of Heidelberg, Heidelberg, Germany
Hassan, Manal M. (författare)
Department of Gastrointestinal Medical Oncology, University of Texas MD Anderson Cancer Center, TX, Houston, United States
Katzke, Verena (författare)
Division of Cancer Epidemiology, German Cancer Research Center (DKFZ), Heidelberg, Germany
Kurtz, Robert C. (författare)
Gastroenterology, Hepatology, Nutrition Service, Memorial Sloan Kettering Cancer Center, NY, United States
Lee, I-Min (författare)
Department of Epidemiology, Harvard T.H. Chan School of Public Health, MA, Boston, United States; Division of Preventive Medicine, Brigham and Women's Hospital, MA, Boston, United States
Malats, Núria (författare)
Genetic and Molecular Epidemiology Group, Spanish National Cancer Research Center (CNIO), Madrid, Spain
Murphy, Neil (författare)
Section of Nutrition and Metabolism, International Agency for Research on Cancer, Lyon, France
Oberg, Ann L. (författare)
Department of Quantitative Health Sciences, Mayo Clinic College of Medicine, MN, Rochester, United States
Orlow, Irene (författare)
Department of Epidemiology and Biostatistics, Memorial Sloan Kettering Cancer Center, NY, United States
Porta, Miquel (författare)
Hospital del Mar Institute of Medical Research (IMIM), Universitat Autònoma de Barcelona, Spain
Real, Francisco X. (författare)
Epithelial Carcinogenesis Group, Spanish National Cancer Research Centre-CNIO, Madrid, Spain
Rothman, Nathaniel (författare)
Division of Cancer Epidemiology and Genetics, NCI, NIH, MD, Bethesda, Liberia
Sesso, Howard D. (författare)
Department of Epidemiology, Harvard T.H. Chan School of Public Health, MA, Boston, United States; Division of Preventive Medicine, Brigham and Women's Hospital, MA, Boston, United States
Silverman, Debra T. (författare)
Division of Cancer Epidemiology and Genetics, NCI, NIH, MD, Bethesda, Liberia
Thompson, Ian M. (författare)
CHRISTUS Santa Rosa Hospital - Medical Center, TX, San Antonio, United States
Wactawski-Wende, Jean (författare)
Department of Epidemiology and Environmental Health, University of Buffalo, NY, Buffalo, United States
Wang, Xiaoliang (författare)
Cancer Prevention Program, Fred Hutchinson Cancer Research Center, WA, Seattle, United States
Wentzensen, Nicolas (författare)
Division of Cancer Epidemiology and Genetics, NCI, NIH, MD, Bethesda, Liberia
Yu, Herbert (författare)
Cancer Epidemiology Division, Population Sciences in the Pacific Program, University of Hawaii Cancer Center, University of Hawaii at Manoa, HI, Honolulu, United States
Zeleniuch-Jacquotte, Anne (författare)
Departments of Population Health and Environmental Medicine, NYU Perlmutter Comprehensive Cancer Center, NY, United States
Yu, Kai (författare)
Division of Cancer Epidemiology and Genetics, NCI, NIH, MD, Bethesda, Liberia
Wolpin, Brian M. (författare)
Department of Medical Oncology, Dana-Farber Cancer Institute, MA, Boston, United States
Duell, Eric J. (författare)
Unit of Nutrition and Cancer, Cancer Epidemiology Research Program, Bellvitge Biomedical Research Institute (IDIBELL), Catalan Institute of Oncology (ICO), Barcelona, Spain
Li, Donghui (författare)
Department of Gastrointestinal Medical Oncology, University of Texas MD Anderson Cancer Center, TX, Houston, United States
Hung, Rayjean J. (författare)
Lunenfeld-Tanenbaum Research Institute of Sinai Health System, University of Toronto, Toronto, Canada
Perdomo, Sandra (författare)
Genomic Epidemiology Branch, International Agency for Research on Cancer (IARC/WHO), Lyon, France
McCullough, Marjorie L. (författare)
Department of Population Science, American Cancer Society, Atlanta, Georgia
Freedman, Neal D. (författare)
Division of Cancer Epidemiology and Genetics, NCI, NIH, MD, Bethesda, Liberia
Patel, Alpa V. (författare)
Department of Population Science, American Cancer Society, Atlanta, Georgia
Peters, Ulrike (författare)
Division of Public Health Sciences, Fred Hutchinson Cancer Research Center, WA, Seattle, United States
Riboli, Elio (författare)
Department of Epidemiology, Harvard T.H. Chan School of Public Health, MA, Boston, United States; Division of Preventive Medicine, Brigham and Women's Hospital, MA, Boston, United States
Sund, Malin (författare)
Umeå universitet,Institutionen för kirurgisk och perioperativ vetenskap
Tjønneland, Anne (författare)
Danish Cancer Society Research Center, Copenhagen, Denmark
Zhong, Jun (författare)
Division of Cancer Epidemiology and Genetics, NCI, NIH, MD, Bethesda, Liberia
Van Den Eeden, Stephen K. (författare)
Division of Research, Northern California, Kaiser Permanente, CA, Oakland, United States; Department of Urology, University of California San Francisco, CA, San Francisco, United States
Kraft, Peter (författare)
Department of Epidemiology, Harvard T.H. Chan School of Public Health, MA, Boston, United States
Risch, Harvey A. (författare)
Department of Chronic Disease Epidemiology, Yale School of Public Health, CT, New Haven, United States
Amundadottir, Laufey T. (författare)
Division of Cancer Epidemiology and Genetics, NCI, NIH, MD, Bethesda, Liberia
Klein, Alison P. (författare)
Department of Epidemiology, Johns Hopkins School of Public Health, MD, Baltimore, Liberia; Department of Oncology, Sidney Kimmel Comprehensive Cancer Center, Johns Hopkins School of Medicine, MD, Baltimore, Liberia; Department of Pathology, Sol Goldman Pancreatic Cancer Research Center, Johns Hopkins School of Medicine, MD, Baltimore, Liberia
Stolzenberg-Solomon, Rachael Z. (författare)
Division of Cancer Epidemiology and Genetics, NCI, NIH, MD, Bethesda, Liberia
Antwi, Samuel O. (författare)
Division of Epidemiology, Department of Quantitative Health Sciences, Mayo Clinic, FL, Jacksonville, Puerto Rico; Division of Gastroenterology and Hepatology, Department of Internal Medicine, Mayo Clinic, FL, Jacksonville, Puerto Rico
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 (creator_code:org_t)
American Association For Cancer Research (AACR), 2023
2023
Engelska.
Ingår i: Cancer Epidemiology, Biomarkers and Prevention. - : American Association For Cancer Research (AACR). - 1055-9965 .- 1538-7755. ; 32:9, s. 1265-1269
  • Tidskriftsartikel (refereegranskat)
Abstract Ämnesord
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  • BACKGROUND: There are conflicting data on whether nonalcoholic fatty liver disease (NAFLD) is associated with susceptibility to pancreatic cancer. Using Mendelian randomization (MR), we investigated the relationship between genetic predisposition to NAFLD and risk for pancreatic cancer.METHODS: Data from genome-wide association studies (GWAS) within the Pancreatic Cancer Cohort Consortium (PanScan; cases n = 5,090, controls n = 8,733) and the Pancreatic Cancer Case Control Consortium (PanC4; cases n = 4,163, controls n = 3,792) were analyzed. We used data on 68 genetic variants with four different MR methods [inverse variance weighting (IVW), MR-Egger, simple median, and penalized weighted median] separately to predict genetic heritability of NAFLD. We then assessed the relationship between each of the four MR methods and pancreatic cancer risk, using logistic regression to calculate ORs and 95% confidence intervals (CI), adjusting for PC risk factors, including obesity and diabetes.RESULTS: No association was found between genetically predicted NAFLD and pancreatic cancer risk in the PanScan or PanC4 samples [e.g., PanScan, IVW OR, 1.04; 95% confidence interval (CI), 0.88-1.22; MR-Egger OR, 0.89; 95% CI, 0.65-1.21; PanC4, IVW OR, 1.07; 95% CI, 0.90-1.27; MR-Egger OR, 0.93; 95% CI, 0.67-1.28]. None of the four MR methods indicated an association between genetically predicted NAFLD and pancreatic cancer risk in either sample.CONCLUSIONS: Genetic predisposition to NAFLD is not associated with pancreatic cancer risk.IMPACT: Given the close relationship between NAFLD and metabolic conditions, it is plausible that any association between NAFLD and pancreatic cancer might reflect host metabolic perturbations (e.g., obesity, diabetes, or metabolic syndrome) and does not necessarily reflect a causal relationship between NAFLD and pancreatic cancer.

Ämnesord

MEDICIN OCH HÄLSOVETENSKAP  -- Klinisk medicin -- Cancer och onkologi (hsv//swe)
MEDICAL AND HEALTH SCIENCES  -- Clinical Medicine -- Cancer and Oncology (hsv//eng)
MEDICIN OCH HÄLSOVETENSKAP  -- Medicinska och farmaceutiska grundvetenskaper -- Medicinsk genetik (hsv//swe)
MEDICAL AND HEALTH SCIENCES  -- Basic Medicine -- Medical Genetics (hsv//eng)

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King, Sontoria D ...
Veliginti, Swath ...
Brouwers, Martij ...
Ren, Zhewen
Zheng, Wei
Setiawan, Veroni ...
visa fler...
Wilkens, Lynne R ...
Shu, Xiao-Ou
Arslan, Alan A.
Beane Freeman, L ...
Bracci, Paige M.
Canzian, Federic ...
Du, Mengmeng
Gallinger, Steve ...
Giles, Graham G.
Goodman, Phyllis ...
Haiman, Christop ...
Kogevinas, Manol ...
Kooperberg, Char ...
LeMarchand, Loic
Neale, Rachel E.
Visvanathan, Kal ...
White, Emily
Albanes, Demetri ...
Andreotti, Gabri ...
Babic, Ana
Berndt, Sonja I.
Brais, Lauren K.
Brennan, Paul
Buring, Julie E.
Rabe, Kari G.
Bamlet, William ...
Chanock, Stephen ...
Fuchs, Charles S ...
Gaziano, J Micha ...
Giovannucci, Edw ...
Hackert, Thilo
Hassan, Manal M.
Katzke, Verena
Kurtz, Robert C.
Lee, I-Min
Malats, Núria
Murphy, Neil
Oberg, Ann L.
Orlow, Irene
Porta, Miquel
Real, Francisco ...
Rothman, Nathani ...
Sesso, Howard D.
Silverman, Debra ...
Thompson, Ian M.
Wactawski-Wende, ...
Wang, Xiaoliang
Wentzensen, Nico ...
Yu, Herbert
Zeleniuch-Jacquo ...
Yu, Kai
Wolpin, Brian M.
Duell, Eric J.
Li, Donghui
Hung, Rayjean J.
Perdomo, Sandra
McCullough, Marj ...
Freedman, Neal D ...
Patel, Alpa V.
Peters, Ulrike
Riboli, Elio
Sund, Malin
Tjønneland, Anne
Zhong, Jun
Van Den Eeden, S ...
Kraft, Peter
Risch, Harvey A.
Amundadottir, La ...
Klein, Alison P.
Stolzenberg-Solo ...
Antwi, Samuel O.
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