Design and methodological considerations for biomarker discovery and validation in the Integrative Analysis of Lung Cancer Etiology and Risk (INTEGRAL) Program

↓ Direkt till sidans innehåll
↓ Direkt till sidans sekundära innehåll (sidomenyn)

Tyck till om SwePub Sök här!

Search: WFRF:(Sesso Howard D) > Design and methodol...

Design and methodological considerations for biomarker discovery and validation in the Integrative Analysis of Lung Cancer Etiology and Risk (INTEGRAL) Program

Robbins, Hilary A. (author): Genomic Epidemiology Branch, International Agency for Research on Cancer, Lyon, France

Alcala, Karine (author): Genomic Epidemiology Branch, International Agency for Research on Cancer, Lyon, France

Moez, Elham Khodayari (author): Prosserman Centre for Population Health Research, Lunenfeld-Tanenbaum Research Institute, Sinai Health, Toronto, Canada

Guida, Florence (author): Environment and Lifestyle Epidemiology Branch, International Agency for Research on Cancer, Lyon, France

Thomas, Sera (author): Prosserman Centre for Population Health Research, Lunenfeld-Tanenbaum Research Institute, Sinai Health, Toronto, Canada

Zahed, Hana (author): Genomic Epidemiology Branch, International Agency for Research on Cancer, Lyon, France

Warkentin, Matthew T. (author): Prosserman Centre for Population Health Research, Lunenfeld-Tanenbaum Research Institute, Sinai Health, Toronto, Canada; Dalla Lana School of Public Health, University of Toronto, Toronto, Canada

Smith-Byrne, Karl (author): Cancer Epidemiology Unit, University of Oxford, Oxford, United Kingdom

Brhane, Yonathan (author): Prosserman Centre for Population Health Research, Lunenfeld-Tanenbaum Research Institute, Sinai Health, Toronto, Canada

Muller, David (author): Division of Genetic Medicine, Imperial College London School of Public Health, London, United Kingdom

Feng, Xiaoshuang (author): Genomic Epidemiology Branch, International Agency for Research on Cancer, Lyon, France

Albanes, Demetrius (author): Division of Cancer Epidemiology and Genetics, National Cancer Institute, MD, Rockville

Aldrich, Melinda C. (author): Department of Medicine, Vanderbilt University Medical Center, TN, Nashville, United States

Arslan, Alan A. (author): Departments of Obstetrics and Gynecology and Population Health, New York University Grossman School of Medicine, NY, New York, United States

Bassett, Julie (author): Cancer Epidemiology Division, Cancer Council Victoria, Melbourne, Australia

Berg, Christine D. (author): Retired, MD, Bethesda

Cai, Qiuyin (author): Division of Epidemiology, Department of Medicine, Vanderbilt University Medical Center, TN, Nashville, United States

Chen, Chu (author): Program in Epidemiology and the Women's Health Initiative Clinical Coordinating Center, Division of Public Health Sciences, Fred Hutchinson Cancer Research Center, WA, Seattle, United States

Davies, Michael P.A. (author): Molecular & Clinical Cancer Medicine, University of Liverpool, Liverpool, United Kingdom

Diergaarde, Brenda (author): Department of Human Genetics, Graduate School of Public Health, University of Pittsburgh, PA, Pittsburgh, United States; UPMC Hillman Cancer Centre, PA, Pittsburgh, United States

Field, John K. (author): Molecular & Clinical Cancer Medicine, University of Liverpool, Liverpool, United Kingdom

Freedman, Neal D. (author): Division of Cancer Epidemiology and Genetics, National Cancer Institute, MD, Rockville

Huang, Wen-Yi (author): Division of Cancer Epidemiology and Genetics, National Cancer Institute, MD, Rockville

Johansson, Mikael (author): Umeå universitet,Onkologi

Jones, Michael (author): Division of Genetics and Epidemiology, Institute of Cancer Research, London, United Kingdom

Koh, Woon-Puay (author): Healthy Longevity Translational Research Program, Yong Loo Lin School of Medicine, National University of Singapore, Singapore, Singapore; Singapore Institute for Clinical Sciences, Agency for Science Technology and Research (A*STAR), Singapore, Singapore

Lam, Stephen (author): Integrative Oncology, British Columbia Cancer Agency, Vancouver, Canada

Lan, Qing (author): Division of Cancer Epidemiology and Genetics, National Cancer Institute, MD, Rockville

Langhammer, Arnulf (author): HUNT Research Center, Department of Public Health and Nursing, NTNU Norwegian University of Science and Technology, Levanger, Norway; Levanger Hospital, Nord-Trøndelag Hospital Trust, Levanger, Norway

Liao, Linda M. (author): Division of Cancer Epidemiology and Genetics, National Cancer Institute, MD, Rockville

Liu, Geoffrey (author): Computational Biology and Medicine Program, Princess Margaret Cancer Center, Toronto, Canada

Malekzadeh, Reza (author): Digestive Disease Research Institute, Tehran University of Medical Sciences, Tehran, Iran

Milne, Roger L. (author): Cancer Epidemiology Division, Cancer Council Victoria, Melbourne, Australia; Centre for Epidemiology and Biostatistics, Melbourne School of Population and Global Health, University of Melbourne, Parkville, Australia; School of Clinical Sciences at Monash Health, Monash University, Melbourne, Australia

Montuenga, Luis M. (author): Center of Applied Medical Research (CIMA) and Schools of Sciences and Medicine, University of Navarra, Pamplona, Spain; IDISNA, Pamplona, Spain; CIBERONC, Madrid, Spain

Rohan, Thomas (author): Department of Epidemiology & Population Health, Albert Einstein College of Medicine, NY, Bronx, United States

Sesso, Howard D. (author): Brigham and Women's Hospital, Harvard Medical School, MA, Boston

Severi, Gianluca (author): Inserm, Université Paris-Saclay, Villejuif, France

Sheikh, Mahdi (author): Genomic Epidemiology Branch, International Agency for Research on Cancer, Lyon, France

Sinha, Rashmi (author): Division of Cancer Epidemiology and Genetics, National Cancer Institute, MD, Rockville

Shu, Xiao-Ou (author): Division of Epidemiology, Department of Medicine, Vanderbilt University Medical Center, TN, Nashville, United States

Stevens, Victoria L. (author): Rollins School of Public Health, Emory University, GA, Atlanta

Tammemägi, Martin C. (author): Department of Health Sciences, Brock University, ON, St. Cathaarines, Canada; Prevention and Cancer Control, Ontario Health, ON, Toronto, Canada

Tinker, Lesley F. (author): Women's Health Initiative Clinical Coordinating Center, Division of Public Health Sciences, Fred Hutchinson Cancer Research Center, WA, Seattle, United States

Visvanathan, Kala (author): Department of Epidemiology, Johns Hopkins Bloomberg School of Public Health, MD, Baltimore

Wang, Ying (author): American Cancer Society, GA, Atlanta

Wang, Renwei (author): UPMC Hillman Cancer Center, University of Pittsburgh, PA, Pittsburgh, United States

Weinstein, Stephanie J. (author): Division of Cancer Epidemiology and Genetics, National Cancer Institute, MD, Rockville

White, Emily (author): Cancer Prevention Research Program, Fred Hutchinson Cancer Research Center, WA, Seattle, United States

Wilson, David (author): Division of Pulmonary, Allergy, and Critical Care Medicine, Department of Medicine, University of Pittsburgh, PA, Pittsburgh, United States

Yuan, Jian-Min (author): UPMC Hillman Cancer Centre, PA, Pittsburgh, United States; Department of Epidemiology, Graduate Schoolf of Public Health, University of Pittsburgh, PA, Pittsburgh, United States

Zhang, Xuehong (author): Brigham and Women's Hospital, Harvard Medical School, MA, Boston

Zheng, Wei (author): Division of Epidemiology, Department of Medicine, Vanderbilt University Medical Center, TN, Nashville, United States

Amos, Christopher I. (author): Institute for Clinical and Translational Research, Baylor College of Medicine, TX, Houston, United States

Brennan, Paul (author): Genomic Epidemiology Branch, International Agency for Research on Cancer, Lyon, France

Johansson, Mattias (author): Genomic Epidemiology Branch, International Agency for Research on Cancer, Lyon, France

Hung, Rayjean J. (author): Prosserman Centre for Population Health Research, Lunenfeld-Tanenbaum Research Institute, Sinai Health, Toronto, Canada; Dalla Lana School of Public Health, University of Toronto, Toronto, Canada

show less...

(creator_code:org_t)

Elsevier, 2023
2023
English.
In: Annals of Epidemiology. - : Elsevier. - 1047-2797 .- 1873-2585. ; 77, s. 1-12

Related links:: https://doi.org/10.1...; show more...; https://umu.diva-por... (primary) (Raw object); https://urn.kb.se/re...; https://doi.org/10.1...; show less...

Journal article (peer-reviewed)

Abstract Subject headings

The Integrative Analysis of Lung Cancer Etiology and Risk (INTEGRAL) program is an NCI-funded initiative with an objective to develop tools to optimize low-dose CT (LDCT) lung cancer screening. Here, we describe the rationale and design for the Risk Biomarker and Nodule Malignancy projects within INTEGRAL. The overarching goal of these projects is to systematically investigate circulating protein markers to include on a panel for use (i) pre-LDCT, to identify people likely to benefit from screening, and (ii) post-LDCT, to differentiate benign versus malignant nodules. To identify informative proteins, the Risk Biomarker project measured 1161 proteins in a nested-case control study within 2 prospective cohorts (n = 252 lung cancer cases and 252 controls) and replicated associations for a subset of proteins in 4 cohorts (n = 479 cases and 479 controls). Eligible participants had a current or former history of smoking and cases were diagnosed up to 3 years following blood draw. The Nodule Malignancy project measured 1078 proteins among participants with a heavy smoking history within four LDCT screening studies (n = 425 cases diagnosed up to 5 years following blood draw, 430 benign-nodule controls, and 398 nodule-free controls). The INTEGRAL panel will enable absolute quantification of 21 proteins. We will evaluate its performance in the Risk Biomarker project using a case-cohort study including 14 cohorts (n = 1696 cases and 2926 subcohort representatives), and in the Nodule Malignancy project within five LDCT screening studies (n = 675 cases, 680 benign-nodule controls, and 648 nodule-free controls). Future progress to advance lung cancer early detection biomarkers will require carefully designed validation, translational, and comparative studies.

Find in a library

Annals of Epidemiology (Search for host publication in LIBRIS)

To the university's database

Find more in SwePub

By the author/editor: Robbins, Hilary ...; Alcala, Karine; Moez, Elham Khod ...; Guida, Florence; Thomas, Sera; Zahed, Hana; show more...; Warkentin, Matth ...; Smith-Byrne, Kar ...; Brhane, Yonathan; Muller, David; Feng, Xiaoshuang; Albanes, Demetri ...; Aldrich, Melinda ...; Arslan, Alan A.; Bassett, Julie; Berg, Christine ...; Cai, Qiuyin; Chen, Chu; Davies, Michael ...; Diergaarde, Bren ...; Field, John K.; Freedman, Neal D ...; Huang, Wen-Yi; Johansson, Mikae ...; Jones, Michael; Koh, Woon-Puay; Lam, Stephen; Lan, Qing; Langhammer, Arnu ...; Liao, Linda M.; Liu, Geoffrey; Malekzadeh, Reza; Milne, Roger L.; Montuenga, Luis ...; Rohan, Thomas; Sesso, Howard D.; Severi, Gianluca; Sheikh, Mahdi; Sinha, Rashmi; Shu, Xiao-Ou; Stevens, Victori ...; Tammemägi, Marti ...; Tinker, Lesley F ...; Visvanathan, Kal ...; Wang, Ying; Wang, Renwei; Weinstein, Steph ...; White, Emily; Wilson, David; Yuan, Jian-Min; Zhang, Xuehong; Zheng, Wei; Amos, Christophe ...; Brennan, Paul; Johansson, Matti ...; Hung, Rayjean J.; show less...

About the subject

MEDICAL AND HEALTH SCIENCES: MEDICAL AND HEAL ...; and Clinical Medicin ...; and Cancer and Oncol ...

Articles in the publication: Annals of Epidem ...

By the university: Umeå University

Search outside SwePub

Extend your search to:: Google; Google Book Search; Google Scholar

Kungliga biblioteket hanterar dina personuppgifter i enlighet med EU:s dataskyddsförordning (2018), GDPR. Läs mer om hur det funkar här.
Så här hanterar KB dina uppgifter vid användning av denna tjänst.

LIBRIS.kb.se

Design and methodological considerations for biomarker discovery and validation in the Integrative Analysis of Lung Cancer Etiology and Risk (INTEGRAL) Program

Subject headings

Keyword

Publication and Content Type

Find in a library

To the university's database

Find more in SwePub

Search outside SwePub