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Sökning: onr:"swepub:oai:DiVA.org:umu-201376" > Design and methodol...

Design and methodological considerations for biomarker discovery and validation in the Integrative Analysis of Lung Cancer Etiology and Risk (INTEGRAL) Program

Robbins, Hilary A. (författare)
Genomic Epidemiology Branch, International Agency for Research on Cancer, Lyon, France
Alcala, Karine (författare)
Genomic Epidemiology Branch, International Agency for Research on Cancer, Lyon, France
Moez, Elham Khodayari (författare)
Prosserman Centre for Population Health Research, Lunenfeld-Tanenbaum Research Institute, Sinai Health, Toronto, Canada
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Guida, Florence (författare)
Environment and Lifestyle Epidemiology Branch, International Agency for Research on Cancer, Lyon, France
Thomas, Sera (författare)
Prosserman Centre for Population Health Research, Lunenfeld-Tanenbaum Research Institute, Sinai Health, Toronto, Canada
Zahed, Hana (författare)
Genomic Epidemiology Branch, International Agency for Research on Cancer, Lyon, France
Warkentin, Matthew T. (författare)
Prosserman Centre for Population Health Research, Lunenfeld-Tanenbaum Research Institute, Sinai Health, Toronto, Canada; Dalla Lana School of Public Health, University of Toronto, Toronto, Canada
Smith-Byrne, Karl (författare)
Cancer Epidemiology Unit, University of Oxford, Oxford, United Kingdom
Brhane, Yonathan (författare)
Prosserman Centre for Population Health Research, Lunenfeld-Tanenbaum Research Institute, Sinai Health, Toronto, Canada
Muller, David (författare)
Division of Genetic Medicine, Imperial College London School of Public Health, London, United Kingdom
Feng, Xiaoshuang (författare)
Genomic Epidemiology Branch, International Agency for Research on Cancer, Lyon, France
Albanes, Demetrius (författare)
Division of Cancer Epidemiology and Genetics, National Cancer Institute, MD, Rockville
Aldrich, Melinda C. (författare)
Department of Medicine, Vanderbilt University Medical Center, TN, Nashville, United States
Arslan, Alan A. (författare)
Departments of Obstetrics and Gynecology and Population Health, New York University Grossman School of Medicine, NY, New York, United States
Bassett, Julie (författare)
Cancer Epidemiology Division, Cancer Council Victoria, Melbourne, Australia
Berg, Christine D. (författare)
Retired, MD, Bethesda
Cai, Qiuyin (författare)
Division of Epidemiology, Department of Medicine, Vanderbilt University Medical Center, TN, Nashville, United States
Chen, Chu (författare)
Program in Epidemiology and the Women's Health Initiative Clinical Coordinating Center, Division of Public Health Sciences, Fred Hutchinson Cancer Research Center, WA, Seattle, United States
Davies, Michael P.A. (författare)
Molecular & Clinical Cancer Medicine, University of Liverpool, Liverpool, United Kingdom
Diergaarde, Brenda (författare)
Department of Human Genetics, Graduate School of Public Health, University of Pittsburgh, PA, Pittsburgh, United States; UPMC Hillman Cancer Centre, PA, Pittsburgh, United States
Field, John K. (författare)
Molecular & Clinical Cancer Medicine, University of Liverpool, Liverpool, United Kingdom
Freedman, Neal D. (författare)
Division of Cancer Epidemiology and Genetics, National Cancer Institute, MD, Rockville
Huang, Wen-Yi (författare)
Division of Cancer Epidemiology and Genetics, National Cancer Institute, MD, Rockville
Johansson, Mikael (författare)
Umeå universitet,Onkologi
Jones, Michael (författare)
Division of Genetics and Epidemiology, Institute of Cancer Research, London, United Kingdom
Koh, Woon-Puay (författare)
Healthy Longevity Translational Research Program, Yong Loo Lin School of Medicine, National University of Singapore, Singapore, Singapore; Singapore Institute for Clinical Sciences, Agency for Science Technology and Research (A*STAR), Singapore, Singapore
Lam, Stephen (författare)
Integrative Oncology, British Columbia Cancer Agency, Vancouver, Canada
Lan, Qing (författare)
Division of Cancer Epidemiology and Genetics, National Cancer Institute, MD, Rockville
Langhammer, Arnulf (författare)
HUNT Research Center, Department of Public Health and Nursing, NTNU Norwegian University of Science and Technology, Levanger, Norway; Levanger Hospital, Nord-Trøndelag Hospital Trust, Levanger, Norway
Liao, Linda M. (författare)
Division of Cancer Epidemiology and Genetics, National Cancer Institute, MD, Rockville
Liu, Geoffrey (författare)
Computational Biology and Medicine Program, Princess Margaret Cancer Center, Toronto, Canada
Malekzadeh, Reza (författare)
Digestive Disease Research Institute, Tehran University of Medical Sciences, Tehran, Iran
Milne, Roger L. (författare)
Cancer Epidemiology Division, Cancer Council Victoria, Melbourne, Australia; Centre for Epidemiology and Biostatistics, Melbourne School of Population and Global Health, University of Melbourne, Parkville, Australia; School of Clinical Sciences at Monash Health, Monash University, Melbourne, Australia
Montuenga, Luis M. (författare)
Center of Applied Medical Research (CIMA) and Schools of Sciences and Medicine, University of Navarra, Pamplona, Spain; IDISNA, Pamplona, Spain; CIBERONC, Madrid, Spain
Rohan, Thomas (författare)
Department of Epidemiology & Population Health, Albert Einstein College of Medicine, NY, Bronx, United States
Sesso, Howard D. (författare)
Brigham and Women's Hospital, Harvard Medical School, MA, Boston
Severi, Gianluca (författare)
Inserm, Université Paris-Saclay, Villejuif, France
Sheikh, Mahdi (författare)
Genomic Epidemiology Branch, International Agency for Research on Cancer, Lyon, France
Sinha, Rashmi (författare)
Division of Cancer Epidemiology and Genetics, National Cancer Institute, MD, Rockville
Shu, Xiao-Ou (författare)
Division of Epidemiology, Department of Medicine, Vanderbilt University Medical Center, TN, Nashville, United States
Stevens, Victoria L. (författare)
Rollins School of Public Health, Emory University, GA, Atlanta
Tammemägi, Martin C. (författare)
Department of Health Sciences, Brock University, ON, St. Cathaarines, Canada; Prevention and Cancer Control, Ontario Health, ON, Toronto, Canada
Tinker, Lesley F. (författare)
Women's Health Initiative Clinical Coordinating Center, Division of Public Health Sciences, Fred Hutchinson Cancer Research Center, WA, Seattle, United States
Visvanathan, Kala (författare)
Department of Epidemiology, Johns Hopkins Bloomberg School of Public Health, MD, Baltimore
Wang, Ying (författare)
American Cancer Society, GA, Atlanta
Wang, Renwei (författare)
UPMC Hillman Cancer Center, University of Pittsburgh, PA, Pittsburgh, United States
Weinstein, Stephanie J. (författare)
Division of Cancer Epidemiology and Genetics, National Cancer Institute, MD, Rockville
White, Emily (författare)
Cancer Prevention Research Program, Fred Hutchinson Cancer Research Center, WA, Seattle, United States
Wilson, David (författare)
Division of Pulmonary, Allergy, and Critical Care Medicine, Department of Medicine, University of Pittsburgh, PA, Pittsburgh, United States
Yuan, Jian-Min (författare)
UPMC Hillman Cancer Centre, PA, Pittsburgh, United States; Department of Epidemiology, Graduate Schoolf of Public Health, University of Pittsburgh, PA, Pittsburgh, United States
Zhang, Xuehong (författare)
Brigham and Women's Hospital, Harvard Medical School, MA, Boston
Zheng, Wei (författare)
Division of Epidemiology, Department of Medicine, Vanderbilt University Medical Center, TN, Nashville, United States
Amos, Christopher I. (författare)
Institute for Clinical and Translational Research, Baylor College of Medicine, TX, Houston, United States
Brennan, Paul (författare)
Genomic Epidemiology Branch, International Agency for Research on Cancer, Lyon, France
Johansson, Mattias (författare)
Genomic Epidemiology Branch, International Agency for Research on Cancer, Lyon, France
Hung, Rayjean J. (författare)
Prosserman Centre for Population Health Research, Lunenfeld-Tanenbaum Research Institute, Sinai Health, Toronto, Canada; Dalla Lana School of Public Health, University of Toronto, Toronto, Canada
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 (creator_code:org_t)
Elsevier, 2023
2023
Engelska.
Ingår i: Annals of Epidemiology. - : Elsevier. - 1047-2797 .- 1873-2585. ; 77, s. 1-12
  • Tidskriftsartikel (refereegranskat)
Abstract Ämnesord
Stäng  
  • The Integrative Analysis of Lung Cancer Etiology and Risk (INTEGRAL) program is an NCI-funded initiative with an objective to develop tools to optimize low-dose CT (LDCT) lung cancer screening. Here, we describe the rationale and design for the Risk Biomarker and Nodule Malignancy projects within INTEGRAL. The overarching goal of these projects is to systematically investigate circulating protein markers to include on a panel for use (i) pre-LDCT, to identify people likely to benefit from screening, and (ii) post-LDCT, to differentiate benign versus malignant nodules. To identify informative proteins, the Risk Biomarker project measured 1161 proteins in a nested-case control study within 2 prospective cohorts (n = 252 lung cancer cases and 252 controls) and replicated associations for a subset of proteins in 4 cohorts (n = 479 cases and 479 controls). Eligible participants had a current or former history of smoking and cases were diagnosed up to 3 years following blood draw. The Nodule Malignancy project measured 1078 proteins among participants with a heavy smoking history within four LDCT screening studies (n = 425 cases diagnosed up to 5 years following blood draw, 430 benign-nodule controls, and 398 nodule-free controls). The INTEGRAL panel will enable absolute quantification of 21 proteins. We will evaluate its performance in the Risk Biomarker project using a case-cohort study including 14 cohorts (n = 1696 cases and 2926 subcohort representatives), and in the Nodule Malignancy project within five LDCT screening studies (n = 675 cases, 680 benign-nodule controls, and 648 nodule-free controls). Future progress to advance lung cancer early detection biomarkers will require carefully designed validation, translational, and comparative studies.

Ämnesord

MEDICIN OCH HÄLSOVETENSKAP  -- Klinisk medicin -- Cancer och onkologi (hsv//swe)
MEDICAL AND HEALTH SCIENCES  -- Clinical Medicine -- Cancer and Oncology (hsv//eng)

Nyckelord

biomarker discovery and validation
biomarkers
early detection
Lung cancer screening
nodule malignancy
risk prediction
study design

Publikations- och innehållstyp

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