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Neurobiology of Pos...
Neurobiology of Postischemic Recuperation in the Aged Mammalian Brain
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- Popa-Wagner, Aurel (author)
- University of Greifswald
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Balseanu, Adrian (author)
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- Zagrean, Leon (author)
- Carol Davila University of Medicine and Pharmacy
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Shah, Imtiaz M. (author)
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Di Napoli, Mario (author)
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- Ahlenius, Henrik (author)
- Lund University,Lunds universitet,Stamceller, åldrande och neurodegeneration,Forskargrupper vid Lunds universitet,Stem Cells, Aging and Neurodegeneration,Lund University Research Groups
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- Kokaia, Zaal (author)
- Lund University,Lunds universitet,Stamcellscentrum (SCC),Avdelningen för stamcellsforskning,Institutionen för laboratoriemedicin,Medicinska fakulteten,Stem Cell Center,Division of stem cell research,Department of Laboratory Medicine,Faculty of Medicine
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(creator_code:org_t)
- Oxford University PressNew York, 2010
- 2010
- English.
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In: Neurovascular Medicine : Pursuing Cellular Longevity for Healthy Aging - Pursuing Cellular Longevity for Healthy Aging. - : Oxford University PressNew York. - 9780195326697 - 9780199864874
- Related links:
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http://dx.doi.org/10...
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https://doi.org/10.1...
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Abstract
Subject headings
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- Old age is associated with an enhanced susceptibility to stroke and poor recovery from brain injury, but the cellular processes underlying these phenomena are not well understood. Potential mechanism underlying functional recovery after brain ischemia in aged subjects include neuroinflammation, changes in brain plasticity-promoting factors, unregulated expression of neurotoxic factors, or differences in the generation of scar tissue that impedes the formation of new axons and blood vessels in the infarcted region. Studies suggest that behaviorally, aged rats were more severely impaired by ischemia than were young rats and showed diminished functional recovery. Both in old and young rats, the early intense proliferative activity following stroke leads to a precipitous formation of growthinhibiting scar tissue, a phenomenon amplified by the persistent expression of neurotoxic factors. Recent evidence shows that the human brain can respond to stroke with increased progenitor proliferation in aged patients, opening the possibilities of utilizing this intrinsic attempt for neuroregeneration of the human brain as a potential therapy for ischemic stroke.
Subject headings
- MEDICIN OCH HÄLSOVETENSKAP -- Medicinska och farmaceutiska grundvetenskaper -- Neurovetenskaper (hsv//swe)
- MEDICAL AND HEALTH SCIENCES -- Basic Medicine -- Neurosciences (hsv//eng)
Keyword
- Brain
- Ischemic stroke
- Neurobiology
- Neuroinflammation
- Neuroregeneration
- Neurotoxic factors
- Scar tissue
Publication and Content Type
- kap (subject category)
- ref (subject category)
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