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Expression of retin...
Expression of retinoic acid target genes in coronary artery disease
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- Bilbija, Dusan (författare)
- University of Oslo, Oslo, Norway
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- Elmabsout, Ali Ateia, 1977- (författare)
- Örebro universitet,Institutionen för hälsovetenskap och medicin
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- Sagave, Julia (författare)
- University of Oslo, Oslo, Norway
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- Haugen, Fred (författare)
- University of Oslo, Oslo, Norway
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- Bastani, Nasser (författare)
- Departments of Nutrition, Institute of Basic Medical Sciences, University of Oslo, Oslo, Norway
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- Dahl, Christen Peder (författare)
- University of Oslo, Oslo, Norway; Department of Cardiology, Oslo University Hospital, Oslo, Norway
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- Gullestad, Lars (författare)
- University of Oslo, Oslo, Norway; Department of Cardiology, Oslo University Hospital, Oslo, Norway
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- Sirsjö, Allan (författare)
- Örebro universitet,Institutionen för hälsovetenskap och medicin
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- Blomhoff, Rune (författare)
- Departments of Nutrition, Institute of Basic Medical Sciences, Oslo University, Oslo, Norway
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- Valen, Guro (författare)
- University of Oslo, Oslo, Norway
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(creator_code:org_t)
- 2014-01-13
- 2014
- Engelska.
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Ingår i: International Journal of Molecular Medicine. - Athens, Greece : Spandidos Publications. - 1107-3756 .- 1791-244X. ; 33:3, s. 677-86
- Relaterad länk:
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https://www.spandido...
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https://urn.kb.se/re...
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https://doi.org/10.3...
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Abstract
Ämnesord
Stäng
- Coronary atherosclerosis can lead to myocardial infarction, and secondarily to post-infarct remodelling and heart failure. Retinoic acid (RA) influences cell proliferation. We hypothesized that RA could influence gene expression and proliferation of cardiovascular cells. Left ventricular biopsies from patients with end-stage heart failure due to coronary artery disease (CAD) or dilated cardiomyopathy were investigated for the content of RA metabolites using liquid chromatography mass spectrometry (LC-MS/MS), and compared with healthy donors. All-trans retinoic acid (ATRA) was increased in the hearts of CAD patients. Gene expression (quantitative PCR) of RA target genes was not influenced in failing hearts, but was increased in the hearts of patients with CAD undergoing open heart surgery. The expression of RA target genes was increased in atherosclerotic lesions from carotid arteries compared to healthy arteries. Stimulation of cardiomyocytes, cardiofibroblasts, smooth muscle cells and endothelial cells with ATRA increased the gene expression of the key enzymes. Cardiofibroblast and smooth muscle cell proliferation were reduced by ATRA, which increased endothelial cell proliferation. Coronary artery disease leads to increased expression of RA target genes. ATRA accumulated in the failing human heart. All investigated cell types present in the heart had induced expression of RA target genes when stimulated with ATRA, which also influenced cell proliferation.
Ämnesord
- MEDICIN OCH HÄLSOVETENSKAP -- Medicinska och farmaceutiska grundvetenskaper -- Cell- och molekylärbiologi (hsv//swe)
- MEDICAL AND HEALTH SCIENCES -- Basic Medicine -- Cell and Molecular Biology (hsv//eng)
Nyckelord
- gene expression
- all-trans retinoic acid
- heart failure
- atherosclerosis
- Medicine
- Medicin
- Medicine
- Medicin
Publikations- och innehållstyp
- ref (ämneskategori)
- art (ämneskategori)
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Till lärosätets databas
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Bilbija, Dusan
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Elmabsout, Ali A ...
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Sagave, Julia
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Haugen, Fred
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Bastani, Nasser
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Dahl, Christen P ...
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visa fler...
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Gullestad, Lars
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Sirsjö, Allan
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Blomhoff, Rune
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Valen, Guro
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visa färre...
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Örebro universitet