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High MAPK p38 activ...
High MAPK p38 activity and low level of IL-10 in intermittent claudication as opposed to stable angina
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- El Marghani, Ahmed M. (author)
- Örebro universitet,Akademin för naturvetenskap och teknik
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- Abuabaid, Hanan M. (author)
- Örebro universitet,Hälsoakademin
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- Hurtig-Wennlöf, Anita (author)
- Örebro universitet,Hälsoakademin
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- Sirsjö, Allan (author)
- Örebro universitet,Hälsoakademin
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- Norgren, Lars (author)
- Department of Surgery, Örebro University Hospital, Örebro, Sweden
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- Kjellén, Peter (author)
- Örebro universitet,Akademin för naturvetenskap och teknik
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(creator_code:org_t)
- Torino : Minerva Medica, 2010
- 2010
- English.
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In: International Journal of Angiology. - Torino : Minerva Medica. - 0392-9590 .- 1827-1839. ; 29:4, s. 331-337
- Related links:
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https://www.minervam...
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https://urn.kb.se/re...
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Abstract
Subject headings
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- AIM:The aim of the present pilot study was to relate the activity of MAPK p38 with the levels of pro- and anti-inflammatory cytokines in a small cohort of patients with either stable angina (N=5) or intermittent claudication (N=5) compared to healthy controls (N=10).METHODS:The activity of MAPK p38 was determined in peripheral blood mononuclear cells, isolated from whole blood by western blot using phospho-specific anti-MAPK p38 antibodies. Cytokine levels of 11 pro- and anti-inflammatory cytokines were determined from the serum using flow cytometry.RESULTS:We found a significant elevation of the MAPK p38 activity in the intermittent claudication group (P=0.0027) compared with the healthy control group whereas the stable angina group showed similar MAPK p38 activity as the healthy control group. The IL-10 level in serum found in the stable angina group was significantly higher compared with both the healthy control group (P=0.0116) and the intermittent claudication group (P=0.0317).CONCLUSION:Our results imply that there is a casual relationship between increased levels of the anti-inflammatory cytokines IL-10 and IL-4 and the activity of the MAPK p38. Possibly has IL-10 a protective role that down-regulates the activity of MAPK p38 and thereby further inflammatory processes in stable angina patients.
Subject headings
- MEDICIN OCH HÄLSOVETENSKAP -- Klinisk medicin -- Kardiologi (hsv//swe)
- MEDICAL AND HEALTH SCIENCES -- Clinical Medicine -- Cardiac and Cardiovascular Systems (hsv//eng)
Keyword
- p38 mitogen-activated protein kinases
- Interleukin-10
- Intermittent claudication
- MEDICINE
- MEDICIN
- Cardiology
- Kardiologi
Publication and Content Type
- ref (subject category)
- art (subject category)
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