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Molecular characteristics of early-onset colorectal cancer according to detailed anatomical locations : comparison with later-onset cases

Ugai, Tomotaka (author)
Program in Mpe Molecular Pathological Epidemiology, Department of Pathology, Brigham and Women's Hospital and Harvard Medical School, MA, Boston, United States; Department of Epidemiology, Harvard T.H. Chan School of Public Health, MA, Boston, United States
Haruki, Koichiro (author)
Program in Mpe Molecular Pathological Epidemiology, Department of Pathology, Brigham and Women's Hospital and Harvard Medical School, MA, Boston, United States
Harrison, Tabitha A. (author)
Public Health Sciences Division, Fred Hutchinson Cancer Center, WA, Seattle, United States
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Cao, Yin (author)
Division of Public Health Sciences, Department of Surgery, Washington University School of Medicine, MO, St Louis, United States; Division of Gastroenterology, Department of Medicine, Washington University School of Medicine, MO, St. Louis, United States
Qu, Conghui (author)
Public Health Sciences Division, Fred Hutchinson Cancer Center, WA, Seattle, United States
Chan, Andrew T. (author)
Clinical and Translational Epidemiology Unit, Massachusetts General Hospital and Harvard Medical School, MA, Boston, United States; Division of Gastroenterology, Massachusetts General Hospital, MA, Boston, United States; Channing Division of Network Medicine, Department of Medicine, Brigham and Women's Hospital and Harvard Medical School, MA, Boston, United States; Department of Immunology and Infectious Diseases, Harvard T.H. Chan School of Public Health, MA, Boston, United States
Campbell, Peter T. (author)
Department of Epidemiology and Population Health, Albert Einstein College of Medicine, NY, Bronx, United States
Akimoto, Naohiko (author)
Program in Mpe Molecular Pathological Epidemiology, Department of Pathology, Brigham and Women's Hospital and Harvard Medical School, MA, Boston, United States
Berndt, Sonja (author)
Division of Cancer Epidemiology and Genetics, National Cancer Institute, National Institutes of Health, MD, Bethesda, United States
Brenner, Hermann (author)
Division of Clinical Epidemiology and Aging Research, German Cancer Research Center (DKFZ), Heidelberg, Germany; Division of Preventive Oncology, German Cancer Research Center (DKFZ) and National Center for Tumor Diseases (NCT), Heidelberg, Germany; German Cancer Consortium (DKTK), German Cancer Research Center (DKFZ), Heidelberg, Germany
Buchanan, Daniel D. (author)
Colorectal Oncogenomics Group, Department of Clinical Pathology, The University of Melbourne, VIC, Parkville, Australia; University of Melbourne Centre for Cancer Research, Victorian Comprehensive Cancer Centre, VIC, Parkville, Australia; Genetic Medicine and Family Cancer Clinic, The Royal Melbourne Hospital, VIC, Parkville, Australia
Chang-Claude, Jenny (author)
Division of Cancer Epidemiology, German Cancer Research Center (DKFZ), Heidelberg, Germany; University Medical Centre Hamburg-Eppendorf, University Cancer Centre Hamburg (UCCH), Hamburg, Germany
Fujiyoshi, Kenji (author)
Program in Mpe Molecular Pathological Epidemiology, Department of Pathology, Brigham and Women's Hospital and Harvard Medical School, MA, Boston, United States
Gallinger, Steven J. (author)
Lunenfeld Tanenbaum Research Institute, Mount Sinai Hospital, University of Toronto, ON, Toronto, Canada
Gunter, Marc J. (author)
Nutrition and Metabolism Section, International Agency for Research on Cancer, World Health Organization, Lyon, France; Cancer Epidemiology Division, Cancer Council Victoria, VIC, Melbourne, Australia; Precision Medicine, School of Clinical Sciences at Monash Health, Monash University, VIC, Clayton, Australia
Hidaka, Akihisa (author)
Public Health Sciences Division, Fred Hutchinson Cancer Center, WA, Seattle, United States
Hoffmeister, Michael (author)
Division of Clinical Epidemiology and Aging Research, German Cancer Research Center (DKFZ), Heidelberg, Germany
Hsu, Li (author)
Public Health Sciences Division, Fred Hutchinson Cancer Center, WA, Seattle, United States
Jenkins, Mark A. (author)
Centre for Epidemiology and Biostatistics, Melbourne School of Population and Global Health, The University of Melbourne, VIC, Melbourne, Australia
Milne, Roger L. (author)
Centre for Epidemiology and Biostatistics, Melbourne School of Population and Global Health, The University of Melbourne, VIC, Melbourne, Australia
Moreno, Victor (author)
Oncology Data Analytics Program, Catalan Institute of Oncology (IDIBELL), L'Hospitalet de Llobregat, Barcelona, Spain; Ciber de Epidemiología y Salud Pública (CIBERESP), Madrid, Spain
Newcomb, Polly A. (author)
Public Health Sciences Division, Fred Hutchinson Cancer Center, WA, Seattle, United States; Department of Clinical Sciences, Faculty of Medicine, University of Barcelona, Barcelona, Spain; Colorectal Cancer Group, Oncobell Program, Bellvitge Biomedical Research Institute-IDIBELL, Hospitalet de Llobregat, Barcelona, Spain
Nishihara, Reiko (author)
Program in Mpe Molecular Pathological Epidemiology, Department of Pathology, Brigham and Women's Hospital and Harvard Medical School, MA, Boston, United States; Department of Epidemiology, University of Washington, WA, Seattle, United States; Department of Nutrition, Harvard T.H. Chan School of Public Health, MA, Boston, United States
Pai, Rish K. (author)
Department of Laboratory Medicine and Pathology, Mayo Clinic Arizona, AZ, Scottsdale, United States; Division of Research, Kaiser Permanente Northern California, CA, Oakland, United States
Sakoda, Lori C. (author)
Public Health Sciences Division, Fred Hutchinson Cancer Center, WA, Seattle, United States
Slattery, Martha L. (author)
Department of Internal Medicine, University of Utah, UT, Salt Lake City, United States
Sun, Wei (author)
Public Health Sciences Division, Fred Hutchinson Cancer Center, WA, Seattle, United States
Amitay, Efrat L. (author)
Division of Clinical Epidemiology and Aging Research, German Cancer Research Center (DKFZ), Heidelberg, Germany
Alwers, Elizabeth (author)
Division of Clinical Epidemiology and Aging Research, German Cancer Research Center (DKFZ), Heidelberg, Germany
Thibodeau, Stephen N. (author)
Division of Laboratory Genetics, Department of Laboratory Medicine and Pathology, Mayo Clinic, MN, Rochester, United States
Toland, Amanda E. (author)
Departments of Cancer Biology and Genetics and Internal Medicine, Comprehensive Cancer Center, The Ohio State University, OH, Columbus, United States
van Guelpen, Bethany (author)
Umeå universitet,Wallenberg centrum för molekylär medicin vid Umeå universitet (WCMM),Onkologi
Woods, Michael O. (author)
Memorial University of Newfoundland, Discipline of Genetics, St. John's, Canada
Zaidi, Syed H. (author)
Ontario Institute for Cancer Research, ON, Toronto, Canada
Potter, John D. (author)
Public Health Sciences Division, Fred Hutchinson Cancer Center, WA, Seattle, United States
Giannakis, Marios (author)
Department of Medical Oncology, Dana-Farber Cancer Institute, MA, Boston, United States; Broad Institute of Mit and Harvard, MA, Cambridge, United States
Song, Mingyang (author)
Department of Epidemiology, Harvard T.H. Chan School of Public Health, MA, Boston, United States
Nowak, Jonathan A. (author)
Program in Mpe Molecular Pathological Epidemiology, Department of Pathology, Brigham and Women's Hospital and Harvard Medical School, MA, Boston, United States; Cancer Immunology and Cancer Epidemiology Programs, Dana-Farber Harvard Cancer Center, MA, Boston, United States
Phipps, Amanda I. (author)
Public Health Sciences Division, Fred Hutchinson Cancer Center, WA, Seattle, United States
Peters, Ulrike (author)
Public Health Sciences Division, Fred Hutchinson Cancer Center, WA, Seattle, United States
Ogino, Shuji (author)
Program in Mpe Molecular Pathological Epidemiology, Department of Pathology, Brigham and Women's Hospital and Harvard Medical School, MA, Boston, United States
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Program in Mpe Molecular Pathological Epidemiology, Department of Pathology, Brigham and Women's Hospital and Harvard Medical School, MA, Boston, United States; Department of Epidemiology, Harvard TH. Chan School of Public Health, MA, Boston, United States Program in Mpe Molecular Pathological Epidemiology, Department of Pathology, Brigham and Women's Hospital and Harvard Medical School, MA, Boston, United States (creator_code:org_t)
2022-12-30
2023
English.
In: American Journal of Gastroenterology. - : Wolters Kluwer. - 0002-9270 .- 1572-0241. ; 118:4, s. 712-726
Related links:
https://urn.kb.se/re...
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https://doi.org/10.1...
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  • Journal article (peer-reviewed)
Abstract Subject headings
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  • INTRODUCTION:Early-onset colorectal cancer diagnosed before the age of 50 years has been increasing. Likely reflecting the pathogenic role of the intestinal microbiome, which gradually changes across the entire colorectal length, the prevalence of certain tumor molecular characteristics gradually changes along colorectal subsites. Understanding how colorectal tumor molecular features differ by age and tumor location is important in personalized patient management.METHODS:Using 14,004 cases with colorectal cancer including 3,089 early-onset cases, we examined microsatellite instability (MSI), CpG island methylator phenotype (CIMP), and KRAS and BRAF mutations in carcinomas of the cecum, ascending colon, transverse colon, descending colon, sigmoid colon, and rectum and compared early-onset cases with later-onset cases.RESULTS:The proportions of MSI-high, CIMP-high, and BRAF-mutated early-onset tumors were lowest in the rectum (8.8%, 3.4%, and 3.5%, respectively) and highest in the ascending colon (46% MSI-high; 15% CIMP-high) or transverse colon (8.6% BRAF-mutated) (all Ptrend<0.001 across the rectum to ascending colon). Compared with later-onset tumors, early-onset tumors showed a higher prevalence of MSI-high status and a lower prevalence of CIMP-high status and BRAF mutations in most subsites. KRAS mutation prevalence was higher in the cecum compared with that in the other subsites in both early-onset and later-onset tumors (P < 0.001). Notably, later-onset MSI-high tumors showed a continuous decrease in KRAS mutation prevalence from the rectum (36%) to ascending colon (9%; Ptrend<0.001), followed by an increase in the cecum (14%), while early-onset MSI-high cancers showed no such trend.DISCUSSION:Our findings support biogeographical and pathogenic heterogeneity of colorectal carcinomas in different colorectal subsites and age groups.

Subject headings

MEDICIN OCH HÄLSOVETENSKAP  -- Klinisk medicin -- Cancer och onkologi (hsv//swe)
MEDICAL AND HEALTH SCIENCES  -- Clinical Medicine -- Cancer and Oncology (hsv//eng)

Keyword

colorectal continuum
colorectal neoplasm
epigenetics
mismatch repair
molecular pathological epidemiology

Publication and Content Type

ref (subject category)
art (subject category)

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