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The Global ECT-MRI Research Collaboration (GEMRIC): Establishing a multi-site investigation of the neural mechanisms underlying response to electroconvulsive therapy

Oltedal, Leif (author)
University of Bergen, Norway; University of Calif San Diego, CA 92037 USA; University of Calif San Diego, CA 92093 USA; Haukeland Hospital, Norway
Bartsch, Hauke (author)
University of Calif San Diego, CA 92037 USA; University of Calif San Diego, CA 92093 USA
Evjenth Sorhaug, Ole Johan (author)
University of Bergen, Norway
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Kessler, Ute (author)
University of Bergen, Norway; Haukeland Hospital, Norway
Abbott, Christopher (author)
University of New Mexico, NM 87131 USA
Dols, Annemieke (author)
VUmc Amsterdam, Netherlands
Stek, Max L. (author)
VUmc Amsterdam, Netherlands
Ersland, Lars (author)
Haukeland Hospital, Norway
Emsell, Louise (author)
Katholieke University of Leuven, Belgium
van Eijndhoven, Philip (author)
Donders Institute Brain Cognit and Behav, Netherlands
Argyelan, Miklos (author)
Feinstein Institute Medical Research, NY USA
Tendolkar, Indira (author)
Donders Institute Brain Cognit and Behav, Netherlands
Nordanskog, Pia, 1971- (author)
Linköpings universitet,Centrum för social och affektiv neurovetenskap,Medicinska fakulteten,Region Östergötland, Psykiatriska kliniken
Hamilton, Paul J., 1970- (author)
Linköpings universitet,Centrum för social och affektiv neurovetenskap,Medicinska fakulteten
Balslev Jorgensen, Martin (author)
Psychiat Centre Copenhagen, Denmark
Sommer, Iris E. (author)
University of Medical Centre, Netherlands
Heringa, Sophie M. (author)
University of Medical Centre, Netherlands
Draganski, Bogdan (author)
University of Lausanne, Switzerland; Max Planck Institute Human Brain and Cognit Neurosci, Germany
Redlich, Ronny (author)
Department of Psychiatry, University of Münster, Germany
Dannlowski, Udo (author)
University of Munster, Germany; University of Marburg, Germany
Kugel, Harald (author)
University of Munster, Germany
Bouckaert, Filip (author)
Katholieke University of Leuven, Belgium
Sienaert, Pascal (author)
Katholieke University of Leuven, Belgium
Anand, Amit (author)
Cleveland Clin, OH 44106 USA
Espinoza, Randall (author)
University of Calif Los Angeles, CA USA
Narr, Katherine L. (author)
University of Calif Los Angeles, CA 90024 USA
Holland, Dominic (author)
University of Calif San Diego, CA 92037 USA; University of Calif San Diego, CA 92093 USA
Dale, Anders M. (author)
University of Calif San Diego, CA 92037 USA; University of Calif San Diego, CA 92093 USA; University of Calif San Diego, CA 92093 USA
Oedegaard, Ketil J. (author)
University of Bergen, Norway; Haukeland Hospital, Norway; KG Jebsen Centre Research Neuropsychiat Disorders, Norway
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 (creator_code:org_t)
ELSEVIER SCI LTD, 2017
2017
English.
In: NeuroImage. - : ELSEVIER SCI LTD. - 2213-1582. ; 14, s. 422-432
Related links:
https://doi.org/10.1...
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https://urn.kb.se/re...
https://doi.org/10.1...
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  • Journal article (peer-reviewed)
Abstract Subject headings
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  • Major depression, currently the worlds primary cause of disability, leads to profound personal suffering and increased risk of suicide. Unfortunately, the success of antidepressant treatment varies amongst individuals and can take weeks to months in those who respond. Electroconvulsive therapy (ECT), generally prescribed for the most severely depressed and when standard treatments fail, produces a more rapid response and remains the most effective intervention for severe depression. Exploring the neurobiological effects of ECT is thus an ideal approach to better understand the mechanisms of successful therapeutic response. Though several recent neuroimaging studies show structural and functional changes associated with ECT, not all brain changes associate with clinical outcome. Larger studies that can address individual differences in clinical and treatment parameters may better target biological factors relating to or predictive of ECT-related therapeutic response. We have thus formed the Global ECT-MRI Research Collaboration (GEMRIC) that aims to combine longitudinal neuroimaging as well as clinical, behavioral and other physiological data across multiple independent sites. Here, we summarize the ECT sample characteristics from currently participating sites, and the common data-repository and standardized image analysis pipeline developed for this initiative. This includes data harmonization across sites and MRI platforms, and a method for obtaining unbiased estimates of structural change based on longitudinal measurements with serial MRI scans. The optimized analysis pipeline, together with the large and heterogeneous combined GEMRIC dataset, will provide new opportunities to elucidate the mechanisms of ECT response and the factors mediating and predictive of clinical outcomes, which may ultimately lead to more effective personalized treatment approaches. (C) 2017 The Author(s). Published by Elsevier Inc.

Subject headings

MEDICIN OCH HÄLSOVETENSKAP  -- Klinisk medicin -- Radiologi och bildbehandling (hsv//swe)
MEDICAL AND HEALTH SCIENCES  -- Clinical Medicine -- Radiology, Nuclear Medicine and Medical Imaging (hsv//eng)

Keyword

Electroconvulsive therapy; MRI; Longitudinal; Mega analysis; Multi-site

Publication and Content Type

ref (subject category)
art (subject category)

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