Tyck till om SwePub Sök här!
WFRF:(Stancakova Alena)
Search: WFRF:(Stancakova Alena) > Glucose-Dependent I...
- 4 of 35
- Previous record
- Next record
- To hitlist
Glucose-Dependent Insulinotropic Polypeptide (GIP) Stimulates Osteopontin Expression in the Vasculature via Endothelin-1 and CREB.
-
- Berglund, Lisa (author)
- Lund University,Lunds universitet,Diabetiska komplikationer,Forskargrupper vid Lunds universitet,Diabetic Complications,Lund University Research Groups
-
- Lyssenko, Valeriya (author)
- Lund University,Lunds universitet,Genomik, diabetes och endokrinologi,Forskargrupper vid Lunds universitet,Genomics, Diabetes and Endocrinology,Lund University Research Groups
-
- Ladenvall, Claes (author)
- Lund University,Lunds universitet,Genomik, diabetes och endokrinologi,Forskargrupper vid Lunds universitet,Genomics, Diabetes and Endocrinology,Lund University Research Groups
- show more...
- Pilgaard, Kasper (author)
- Brøns, Charlotte (author)
- Forsblom, Carol (author)
- Stancáková, Alena (author)
- Kuusisto, Johanna (author)
- Lajer, Maria (author)
- Tarnow, Lise (author)
- Madsbad, Sten (author)
- Rossing, Peter (author)
- Kieffer, Timothy J (author)
- Groop, Per-Henrik (author)
- Laakso, Markku (author)
- show less...
- (creator_code:org_t)
- 2015-09-22
- 2016
- English.
- In: Diabetes. - : American Diabetes Association. - 1939-327X .- 0012-1797. ; 65:1, s. 239-254
- Journal article (peer-reviewed)
Abstract
Subject headings
Close
- Glucose-dependent insulinotropic polypeptide (GIP) is an incretin hormone with extrapancreatic effects beyond glycemic control. Here we demonstrate unexpected effects of GIP signaling in the vasculature. GIP induces the expression of the pro-atherogenic cytokine osteopontin (OPN) in mouse arteries, via local release of endothelin-1 (ET-1) and activation of cAMP response element binding protein (CREB). Infusion of GIP increases plasma OPN levels in healthy individuals. Plasma ET-1 and OPN levels are positively correlated in patients with critical limb ischemia. Fasting GIP levels are higher in individuals with a history of cardiovascular disease (myocardial infarction, stroke) when compared to controls. GIP receptor (GIPR) and OPN mRNA levels are higher in carotid endarterectomies from patients with symptoms (stroke, transient ischemic attacks, amaurosis fugax) than in asymptomatic patients; and expression associates to parameters characteristic of unstable and inflammatory plaques (increased lipid accumulation, macrophage infiltration and reduced smooth muscle cell content). While GIPR expression is predominantly endothelial in healthy arteries from human, mouse, rat and pig; remarkable up-regulation is observed in endothelial and smooth muscle cells upon culture conditions yielding a "vascular disease-like" phenotype. Moreover, a common variant rs10423928 in the GIPR gene associated with increased risk of stroke in type 2 diabetes patients.
Subject headings
- MEDICIN OCH HÄLSOVETENSKAP -- Klinisk medicin -- Endokrinologi och diabetes (hsv//swe)
- MEDICAL AND HEALTH SCIENCES -- Clinical Medicine -- Endocrinology and Diabetes (hsv//eng)
Publication and Content Type
- art (subject category)
- ref (subject category)
- 4 of 35
- Previous record
- Next record
- To hitlist
Find more in SwePub
- By the author/editor
- Berglund, Lisa
- Lyssenko, Valeri ...
- Ladenvall, Claes
- Kotova, Olga
- Edsfeldt, Andrea ...
- Pilgaard, Kasper
- show more...
- Alkayyali, Sami
- Brøns, Charlotte
- Forsblom, Carol
- Jonsson, Anna
- Zetterqvist, Ann ...
- Nitulescu, Mihae ...
- Ruiz McDavitt, C ...
- Dunér, Pontus
- Stancáková, Alen ...
- Kuusisto, Johann ...
- Ahlqvist, Emma
- Lajer, Maria
- Tarnow, Lise
- Madsbad, Sten
- Rossing, Peter
- Kieffer, Timothy ...
- Melander, Olle
- Orho-Melander, M ...
- Nilsson, Peter
- Groop, Per-Henri ...
- Vaag, Allan
- Lindblad, Bengt
- Gottsäter, Ander ...
- Laakso, Markku
- Goncalves, Isabe ...
- Groop, Leif
- Gomez, Maria
- show less...
- About the subject
-
- MEDICAL AND HEALTH SCIENCES
- MEDICAL AND HEAL ...
- and Clinical Medicin ...
- and Endocrinology an ...
- Articles in the publication
- Diabetes
- By the university
- Lund University
Search outside SwePub
- Extend your search to:
- Google Book Search
- Google Scholar
Kungliga biblioteket hanterar dina personuppgifter i enlighet med EU:s dataskyddsförordning (2018), GDPR. Läs mer om hur det funkar här.
Så här hanterar KB dina uppgifter vid användning av denna tjänst.
- Copyright © LIBRIS - National Library Systems
- LIBRIS.kb.se
