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Assessing Associations between the AURKA-HMMR-TPX2-TUBG1 Functional Module and Breast Cancer Risk in BRCA1/2 Mutation Carriers

Blanco, Ignacio (author)
Kuchenbaecker, Karoline (author)
Cuadras, Daniel (author)
show more...
Wang, Xianshu (author)
Barrowdale, Daniel (author)
Ruiz de Garibay, Gorka (author)
Librado, Pablo (author)
Sanchez-Gracia, Alejandro (author)
Rozas, Julio (author)
Bonifaci, Nuria (author)
McGuffog, Lesley (author)
Pankratz, Vernon S. (author)
Islam, Abul (author)
Mateo, Francesca (author)
Berenguer, Antoni (author)
Petit, Anna (author)
Catala, Isabel (author)
Brunet, Joan (author)
Feliubadalo, Lidia (author)
Tornero, Eva (author)
Benitez, Javier (author)
Osorio, Ana (author)
Cajal, Teresa Ramon Y. (author)
Nevanlinna, Heli (author)
Aittomaki, Kristiina (author)
Arun, Banu K. (author)
Toland, Amanda E. (author)
Karlan, Beth Y. (author)
Walsh, Christine (author)
Lester, Jenny (author)
Greene, Mark H. (author)
Mai, Phuong L. (author)
Nussbaum, Robert L. (author)
Andrulis, Irene L. (author)
Domchek, Susan M. (author)
Nathanson, Katherine L. (author)
Rebbeck, Timothy R. (author)
Barkardottir, Rosa B. (author)
Jakubowska, Anna (author)
Lubinski, Jan (author)
Durda, Katarzyna (author)
Jaworska-Bieniek, Katarzyna (author)
Claes, Kathleen (author)
Van Maerken, Tom (author)
Diez, Orland (author)
Hansen, Thomas V. (author)
Jonson, Lars (author)
Gerdes, Anne-Marie (author)
Ejlertsen, Bent (author)
de la Hoya, Miguel (author)
Caldes, Trinidad (author)
Dunning, Alison M. (author)
Oliver, Clare (author)
Fineberg, Elena (author)
Cook, Margaret (author)
Peock, Susan (author)
McCann, Emma (author)
Murray, Alex (author)
Jacobs, Chris (author)
Pichert, Gabriella (author)
Lalloo, Fiona (author)
Chu, Carol (author)
Dorkins, Huw (author)
Paterson, Joan (author)
Ong, Kai-Ren (author)
Teixeira, Manuel R. (author)
Teixeira, (author)
Hogervorst, Frans B. L. (author)
van der Hout, Annemarie H. (author)
Seynaeve, Caroline (author)
van der Luijt, Rob B. (author)
Ligtenberg, Marjolijn J. L. (author)
Devilee, Peter (author)
Wijnen, Juul T. (author)
Rookus, Matti A. (author)
Meijers-Heijboer, Hanne E. J. (author)
Blok, Marinus J. (author)
van den Ouweland, Ans M. W. (author)
Aalfs, Cora M. (author)
Rodriguez, Gustavo C. (author)
Phillips, Kelly-Anne A. (author)
Piedmonte, Marion (author)
Nerenstone, Stacy R. (author)
Bae-Jump, Victoria L. (author)
OMalley, David M. (author)
Ratner, Elena S. (author)
Schmutzler, Rita K. (author)
Wappenschmidt, Barbara (author)
Rhiem, Kerstin (author)
Engel, Christoph (author)
Meindl, Alfons (author)
Ditsch, Nina (author)
Arnold, Norbert (author)
Plendl, Hansjoerg J. (author)
Niederacher, Dieter (author)
Sutter, Christian (author)
Wang-Gohrke, Shan (author)
Steinemann, Doris (author)
Preisler-Adams, Sabine (author)
Kast, Karin (author)
Varon-Mateeva, Raymonda (author)
Gehrig, Andrea (author)
Bojesen, Anders (author)
Sokilde Pedersen, Inge (author)
Sunde, Lone (author)
Birk Jensen, Uffe (author)
Thomassen, Mads (author)
Kruse, Torben A. (author)
Foretova, Lenka (author)
Peterlongo, Paolo (author)
Bernard, Loris (author)
Peissel, Bernard (author)
Scuvera, Giulietta (author)
Manoukian, Siranoush (author)
Radice, Paolo (author)
Ottini, Laura (author)
Montagna, Marco (author)
Agata, Simona (author)
Maugard, Christine (author)
Simard, Jacques (author)
Soucy, Penny (author)
Berger, Andreas (author)
Fink-Retter, Anneliese (author)
Singer, Christian F. (author)
Rappaport, Christine (author)
Geschwantler-Kaulich, Daphne (author)
Tea, Muy-Kheng (author)
Pfeiler, Georg (author)
John, Esther M. (author)
Miron, Alex (author)
Neuhausen, Susan L. (author)
Beth Terry, Mary (author)
Chung, Wendy K. (author)
Daly, Mary B. (author)
Goldgar, David E. (author)
Janavicius, Ramunas (author)
Dorfling, Cecilia M. (author)
van Rensburg, Elisabeth J. (author)
Fostira, Florentia (author)
Konstantopoulou, Irene (author)
Garber, Judy (author)
Godwin, Andrew K. (author)
Olah, Edith (author)
Narod, Steven A. (author)
Rennert, Gad (author)
Shimon Paluch, Shani (author)
Laitman, Yael (author)
Friedman, Eitan (author)
Liljegren, Annelie (author)
Rantala, Johanna (author)
Stenmark Askmalm, Marie (author)
Loman, Niklas (author)
Imyanitov, Evgeny N. (author)
Hamann, Ute (author)
Spurdle, Amanda B. (author)
Healey, Sue (author)
Weitzel, Jeffrey N. (author)
Herzog, Josef (author)
Margileth, David (author)
Gorrini, Chiara (author)
Esteller, Manel (author)
Gomez, Antonio (author)
Sayols, Sergi (author)
Vidal, Enrique (author)
Heyn, Holger (author)
Stoppa-Lyonnet, Dominique (author)
Leone, Melanie (author)
Barjhoux, Laure (author)
Fassy-Colcombet, Marion (author)
de Pauw, Antoine (author)
Lasset, Christine (author)
Fert Ferrer, Sandra (author)
Castera, Laurent (author)
Berthet, Pascaline (author)
Cornelis, Francois (author)
Bignon, Yves-Jean (author)
Damiola, Francesca (author)
Mazoyer, Sylvie (author)
Sinilnikova, Olga M. (author)
Maxwell, Christopher A. (author)
Vijai, Joseph (author)
Robson, Mark (author)
Kauff, Noah (author)
Corines, Marina J. (author)
Villano, Danylko (author)
Cunningham, Julie (author)
Lee, Adam (author)
Lindor, Noralane (author)
Lazaro, Conxi (author)
Easton, Douglas F. (author)
Offit, Kenneth (author)
Chenevix-Trench, Georgia (author)
Couch, Fergus J. (author)
Antoniou, Antonis C. (author)
Angel Pujana, Miguel (author)
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Public Library of Science 2015
2015
English.
In: PLoS ONE. - 1932-6203. ; 10:4
  • swepub:Mat__t
Abstract Subject headings
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  • While interplay between BRCA1 and AURKA-RHAMM-TPX2-TUBG1 regulates mammary epithelial polarization, common genetic variation in HMMR (gene product RHAMM) may be associated with risk of breast cancer in BRCA1 mutation carriers. Following on these observations, we further assessed the link between the AURKA-HMMR-TPX2-TUBG1 functional module and risk of breast cancer in BRCA1 or BRCA2 mutation carriers. Forty-one single nucleotide polymorphisms (SNPs) were genotyped in 15,252 BRCA1 and 8,211 BRCA2 mutation carriers and subsequently analyzed using a retrospective likelihood approach. The association of HMMR rs299290 with breast cancer risk in BRCA1 mutation carriers was confirmed: per-allele hazard ratio (HR) = 1.10, 95% confidence interval (CI) 1.04 - 1.15, p = 1.9 x 10(-4) (false discovery rate (FDR)-adjusted p = 0.043). Variation in CSTF1, located next to AURKA, was also found to be associated with breast cancer risk in BRCA2 mutation carriers: rs2426618 per-allele HR = 1.10, 95% CI 1.03 - 1.16, p = 0.005 (FDR-adjusted p = 0.045). Assessment of pairwise interactions provided suggestions (FDR-adjusted p(interaction) values greater than 0.05) for deviations from the multiplicative model for rs299290 and CSTF1 rs6064391, and rs299290 and TUBG1 rs11649877 in both BRCA1 and BRCA2 mutation carriers. Following these suggestions, the expression of HMMR and AURKA or TUBG1 in sporadic breast tumors was found to potentially interact, influencing patients survival. Together, the results of this study support the hypothesis of a causative link between altered function of AURKA-HMMR-TPX2-TUBG1 and breast carcinogenesis in BRCA1/2 mutation carriers.

Subject headings

Medical and Health Sciences  (hsv)
Clinical Medicine  (hsv)
Cancer and Oncology  (hsv)
Medicin och hälsovetenskap  (hsv)
Klinisk medicin  (hsv)
Cancer och onkologi  (hsv)

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By the author/editor
Blanco, Ignacio
Kuchenbaecker, K ...
Cuadras, Daniel
Wang, Xianshu
Barrowdale, Dani ...
Ruiz de Garibay, ...
show more...
Librado, Pablo
Sanchez-Gracia, ...
Rozas, Julio
Bonifaci, Nuria
McGuffog, Lesley
Pankratz, Vernon ...
Islam, Abul
Mateo, Francesca
Berenguer, Anton ...
Petit, Anna
Catala, Isabel
Brunet, Joan
Feliubadalo, Lid ...
Tornero, Eva
Benitez, Javier
Osorio, Ana
Cajal, Teresa Ra ...
Nevanlinna, Heli
Aittomaki, Krist ...
Arun, Banu K.
Toland, Amanda E ...
Karlan, Beth Y.
Walsh, Christine
Lester, Jenny
Greene, Mark H.
Mai, Phuong L.
Nussbaum, Robert ...
Andrulis, Irene ...
Domchek, Susan M ...
Nathanson, Kathe ...
Rebbeck, Timothy ...
Barkardottir, Ro ...
Jakubowska, Anna
Lubinski, Jan
Durda, Katarzyna
Jaworska-Bieniek ...
Claes, Kathleen
Van Maerken, Tom
Diez, Orland
Hansen, Thomas V ...
Jonson, Lars
Gerdes, Anne-Mar ...
Ejlertsen, Bent
de la Hoya, Migu ...
Caldes, Trinidad
Dunning, Alison ...
Oliver, Clare
Fineberg, Elena
Cook, Margaret
Peock, Susan
McCann, Emma
Murray, Alex
Jacobs, Chris
Pichert, Gabriel ...
Lalloo, Fiona
Chu, Carol
Dorkins, Huw
Paterson, Joan
Ong, Kai-Ren
Teixeira, Manuel ...
Teixeira,
Hogervorst, Fran ...
van der Hout, An ...
Seynaeve, Caroli ...
van der Luijt, R ...
Ligtenberg, Marj ...
Devilee, Peter
Wijnen, Juul T.
Rookus, Matti A.
Meijers-Heijboer ...
Blok, Marinus J.
van den Ouweland ...
Aalfs, Cora M.
Rodriguez, Gusta ...
Phillips, Kelly- ...
Piedmonte, Mario ...
Nerenstone, Stac ...
Bae-Jump, Victor ...
OMalley, David M ...
Ratner, Elena S.
Schmutzler, Rita ...
Wappenschmidt, B ...
Rhiem, Kerstin
Engel, Christoph
Meindl, Alfons
Ditsch, Nina
Arnold, Norbert
Plendl, Hansjoer ...
Niederacher, Die ...
Sutter, Christia ...
Wang-Gohrke, Sha ...
Steinemann, Dori ...
Preisler-Adams, ...
Kast, Karin
Varon-Mateeva, R ...
Gehrig, Andrea
Bojesen, Anders
Sokilde Pedersen ...
Sunde, Lone
Birk Jensen, Uff ...
Thomassen, Mads
Kruse, Torben A.
Foretova, Lenka
Peterlongo, Paol ...
Bernard, Loris
Peissel, Bernard
Scuvera, Giuliet ...
Manoukian, Siran ...
Radice, Paolo
Ottini, Laura
Montagna, Marco
Agata, Simona
Maugard, Christi ...
Simard, Jacques
Soucy, Penny
Berger, Andreas
Fink-Retter, Ann ...
Singer, Christia ...
Rappaport, Chris ...
Geschwantler-Kau ...
Tea, Muy-Kheng
Pfeiler, Georg
John, Esther M.
Miron, Alex
Neuhausen, Susan ...
Beth Terry, Mary
Chung, Wendy K.
Daly, Mary B.
Goldgar, David E ...
Janavicius, Ramu ...
Dorfling, Cecili ...
van Rensburg, El ...
Fostira, Florent ...
Konstantopoulou, ...
Garber, Judy
Godwin, Andrew K ...
Olah, Edith
Narod, Steven A.
Rennert, Gad
Shimon Paluch, S ...
Laitman, Yael
Friedman, Eitan
Liljegren, Annel ...
Rantala, Johanna
Stenmark Askmalm ...
Loman, Niklas
Imyanitov, Evgen ...
Hamann, Ute
Spurdle, Amanda ...
Healey, Sue
Weitzel, Jeffrey ...
Herzog, Josef
Margileth, David
Gorrini, Chiara
Esteller, Manel
Gomez, Antonio
Sayols, Sergi
Vidal, Enrique
Heyn, Holger
Stoppa-Lyonnet, ...
Leone, Melanie
Barjhoux, Laure
Fassy-Colcombet, ...
de Pauw, Antoine
Lasset, Christin ...
Fert Ferrer, San ...
Castera, Laurent
Berthet, Pascali ...
Cornelis, Franco ...
Bignon, Yves-Jea ...
Damiola, Frances ...
Mazoyer, Sylvie
Sinilnikova, Olg ...
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