Timing of Staged Nonculprit Artery Revascularization in Patients With ST-Segment Elevation Myocardial Infarction COMPLETE Trial

↓ Direkt till sidans innehåll
↓ Direkt till sidans sekundära innehåll (sidomenyn)

Tyck till om SwePub Sök här!

Sökning: onr:"swepub:oai:DiVA.org:uu-400055" > Timing of Staged No...

1 av 1
Föregående post
Nästa post
Till träfflistan

Timing of Staged Nonculprit Artery Revascularization in Patients With ST-Segment Elevation Myocardial Infarction COMPLETE Trial

Wood, David A. (författare): Univ British Columbia, St Pauls & Vancouver Gen Hosp, Ctr Cardiovasc Innovat, 2775 Laurel St 9th Floor, Vancouver, BC V5Z 1M9, Canada

Cairns, John A. (författare): Univ British Columbia, St Pauls & Vancouver Gen Hosp, Ctr Cardiovasc Innovat, 2775 Laurel St 9th Floor, Vancouver, BC V5Z 1M9, Canada

Wang, Jia (författare): McMaster Univ, Populat Hlth Res Inst, 237 Barton St East, Hamilton, ON L8L 2X2, Canada;Hamilton Hlth Sci, 237 Barton St East, Hamilton, ON L8L 2X2, Canada

visa fler...

Mehran, Roxana (författare): Zena A Wiener Cardiovasc Inst, Icahn Sch Med Mt Sinai, New York, NY USA

Storey, Robert F. (författare): Univ Sheffield, Dept Infect Immun & Cardiovasc Dis, Sheffield, S Yorkshire, England

Nguyen, Helen (författare): McMaster Univ, Populat Hlth Res Inst, 237 Barton St East, Hamilton, ON L8L 2X2, Canada;Hamilton Hlth Sci, 237 Barton St East, Hamilton, ON L8L 2X2, Canada

Meeks, Brandi (författare): McMaster Univ, Populat Hlth Res Inst, 237 Barton St East, Hamilton, ON L8L 2X2, Canada;Hamilton Hlth Sci, 237 Barton St East, Hamilton, ON L8L 2X2, Canada

Kunadian, Vijay (författare): Newcastle Univ, Inst Cellular Med, Fac Med Sci, Newcastle Upon Tyne, Tyne & Wear, England;Newcastle Tyne Hosp NHS Fdn Trust, Cardiothorac Ctr, Freeman Hosp, Newcastle Upon Tyne, Tyne & Wear, England

Tanguay, Jean-Francois (författare): Montreal Heart Inst, Montreal, PQ, Canada;Univ Montreal, Montreal, PQ, Canada

Kim, Hahn-Ho (författare): St Marys Gen Hosp, Kitchener, ON, Canada

Cheema, Asim (författare): St Michaels Hosp, Toronto, ON, Canada

Deghani, Payam (författare): Univ Saskatchewan, Prairie Vasc Res Network, Regina, SK, Canada

Natarajan, Madhu K. (författare): McMaster Univ, Populat Hlth Res Inst, 237 Barton St East, Hamilton, ON L8L 2X2, Canada;Hamilton Hlth Sci, 237 Barton St East, Hamilton, ON L8L 2X2, Canada

Jolly, Sanjit S. (författare): McMaster Univ, Populat Hlth Res Inst, 237 Barton St East, Hamilton, ON L8L 2X2, Canada;Hamilton Hlth Sci, 237 Barton St East, Hamilton, ON L8L 2X2, Canada

Amerena, John (författare): Kardinia House, Geelong, Vic, Australia

Keltai, Matyas (författare): Hungarian Inst Cardiol, Budapest, Hungary

James, Stefan, 1964- (författare): Uppsala universitet,Kardiologi

Hlinomaz, Ota (författare): Univ Hosp St Anne, Brno, Czech Republic

Niemela, Kari (författare): Tampere Univ Hosp, Heart Ctr, Tampere, Finland

AlHabib, Khalid (författare): King Fahad Cardiac Ctr, Dept Cardiac Serv, Jeddah, Saudi Arabia

Lewis, Basil S. (författare): Lady Davis Carmel Med Ctr, Cardiovasc Clin Res Inst, Haifa, Israel

Nguyen, Michel (författare): Univ Sherbrooke, Ctr Hosp, Div Cardiol, Quebec City, PQ, Canada

Sarma, Jaydeep (författare): Wythenshawe Hosp, North West Heart Ctr, Manchester, Lancs, England

Dzavik, Vladimir (författare): Univ Hlth Network, Peter Munk Cardiac Ctr, Toronto, ON, Canada

Della Siega, Anthony (författare): Victoria Heart Inst Fdn, Dept Cardiac Serv, Victoria, BC, Canada

Mehta, Shamir R. (författare): McMaster Univ, Populat Hlth Res Inst, 237 Barton St East, Hamilton, ON L8L 2X2, Canada;Hamilton Hlth Sci, 237 Barton St East, Hamilton, ON L8L 2X2, Canada

visa färre...

(creator_code:org_t)

ELSEVIER SCIENCE INC, 2019
2019
Engelska.
Ingår i: Journal of the American College of Cardiology. - : ELSEVIER SCIENCE INC. - 0735-1097 .- 1558-3597. ; 74:22, s. 2713-2723

Relaterad länk:: https://doi.org/10.1...; visa fler...; https://urn.kb.se/re...; https://doi.org/10.1...; visa färre...

Tidskriftsartikel (refereegranskat)

Abstract Ämnesord

Stäng

BACKGROUND The COMPLETE (Complete vs Culprit-only Revascularization to Treat Multi-vessel Disease After Early PCI for STEMI) trial demonstrated that staged nonculprit lesion percutaneous coronary intervention (PCI) reduced major cardiovascular (CV) events in patients with ST-segment elevation myocardial infarction (STEMI) and multivessel coronary artery disease (CAD). OBJECTIVES The purpose of this study was to determine the effect of nonculprit-lesion PCI timing on major CV outcomes and also the time course of the benefit of complete revascularization. METHODS Following culprit-lesion PCI, 4,041 patients with STEMI and multivessel CAD were randomized to staged nonculprit-lesion PCI or culprit-lesion only PCI. Randomization was stratified according to investigator-planned timing of nonculprit-lesion PCI: during or after the index hospitalization. The first coprimary outcome was the composite of CV death or myocardial infarction (MI). In pre-specified analyses, hazard ratios (HRs) were calculated for each time stratum. Landmark analyses of the entire population were performed within 45 days and after 45 days. RESULTS For nonculprit-lesion PCI planned during the index hospitalization (actual time: median 1 day), CV death or MI was reduced with complete revascularization compared with culprit-lesion only PCI (HR: 0.77; 95% confidence interval [CI]: 0.59 to 1.00). For nonculprit lesion PCI planned to occur after hospital discharge (actual time: median 23 days), CV death or MI was also reduced with complete revascularization (HR: 0.69; 95% CI: 0.49 to 0.97; interaction p = 0.62). Landmark analyses demonstrated an HR of 0.86 (95% CI: 0.59 to 1.24) during the first 45 days and 0.69 (95% CI: 0.54 to 0.89) from 45 days to the end of follow-up for intended nonculprit lesion PCI versus culprit lesion only PCI. CONCLUSIONS Among STEMI patients with multivessel disease, the benefit of complete revascularization over culprit-lesion only PCI was consistent irrespective of the investigator-determined timing of nonculprit-lesion intervention. The benefit of complete revascularization on hard clinical outcomes emerged mainly over the long term. (C) 2019 by the American College of Cardiology Foundation.

Hitta via bibliotek

Journal of the American College of Cardiology (Sök värdpublikationen i LIBRIS)

Till lärosätets databas

1 av 1
Föregående post
Nästa post
Till träfflistan

Hitta mer i SwePub

Om ämnet

MEDICIN OCH HÄLSOVETENSKAP: MEDICIN OCH HÄLS ...; och Klinisk medicin; och Kardiologi

Artiklar i publikationen: Journal of the A ...

Av lärosätet: Uppsala universitet

Sök utanför SwePub

Sök vidare i:: Google; Google Book Search; Google Scholar

Kungliga biblioteket hanterar dina personuppgifter i enlighet med EU:s dataskyddsförordning (2018), GDPR. Läs mer om hur det funkar här.
Så här hanterar KB dina uppgifter vid användning av denna tjänst.

LIBRIS.kb.se

Timing of Staged Nonculprit Artery Revascularization in Patients With ST-Segment Elevation Myocardial Infarction COMPLETE Trial

Ämnesord

Nyckelord

Publikations- och innehållstyp

Hitta via bibliotek

Till lärosätets databas

Hitta mer i SwePub

Sök utanför SwePub