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Growth Differentiat...
Growth Differentiation Factor 15 at 1 Month After an Acute Coronary Syndrome Is Associated With Increased Risk of Major Bleeding.
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- Lindholm, Daniel P, 1982- (author)
- Uppsala universitet,Kardiologi
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- Hagström, Emil (author)
- Uppsala universitet,Kardiologi
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- James, Stefan K, 1964- (author)
- Uppsala universitet,Kardiologi
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Becker, Richard C (author)
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Cannon, Christopher P (author)
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Himmelmann, Anders (author)
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Katus, Hugo A (author)
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Maurer, Gerald (author)
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López-Sendón, José Luis (author)
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Steg, Philippe Gabriel (author)
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Storey, Robert F (author)
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- Siegbahn, Agneta, 1947- (author)
- Uppsala universitet,Klinisk kemi,Uppsala kliniska forskningscentrum (UCR)
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- Wallentin, Lars, 1943- (author)
- Uppsala universitet,Kardiologi
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(creator_code:org_t)
- 2017
- 2017
- English.
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In: Journal of the American Heart Association. - 2047-9980. ; 6:4
- Related links:
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https://uu.diva-port... (primary) (Raw object)
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https://urn.kb.se/re...
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https://doi.org/10.1...
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Abstract
Subject headings
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- BACKGROUND: Growth differentiation factor-15 (GDF-15) is related to major bleeding when measured at initial presentation in patients with acute coronary syndromes (ACSs) treated with dual antiplatelet therapy. It is unknown whether follow-up measurements provide additional information. The objective of this study was to investigate whether GDF-15 measured 1 month after an ACS provides additional information beyond the baseline levels with regard to the risk of major bleeding.METHODS AND RESULTS: GDF-15 was measured at baseline and at 1 month after an ACS in 4049 patients included in the PLATelet inhibition and patient Outcomes (PLATO) trial. The association between 1-month GDF-15 level and non-coronary artery bypass grafting surgery-related major bleeding was assessed by a multivariable Cox model, adjusting for baseline GDF-15, age, anemia, impaired renal function, history of gastrointestinal bleeding, and sex. Elevated GDF-15 (>1800 ng/L) at 1 month was associated with an increased risk of non-coronary artery bypass grafting-related major bleeding (3.9% versus 1.2%; hazard ratio, 3.38; 95% CI, 1.89-6.06), independent of baseline GDF-15. Patients who had elevated GDF-15 levels at baseline and subsequent nonelevated GDF-15 at 1 month had a similar risk as patients who had nonelevated levels at both measurements.CONCLUSIONS: GDF-15 at 1 month after an ACS is related to the risk of bleeding during DAPT and provides additional information on the bleeding risk beyond baseline GDF-15 levels. GDF-15 levels may therefore be useful as part of decision support concerning long-term antithrombotic treatment in patients post-ACS.CLINICAL TRIAL REGISTRATION: URL: http://www.clinicaltrials.gov. Unique identifier: NCT00391872.
Subject headings
- MEDICIN OCH HÄLSOVETENSKAP -- Klinisk medicin -- Kardiologi (hsv//swe)
- MEDICAL AND HEALTH SCIENCES -- Clinical Medicine -- Cardiac and Cardiovascular Systems (hsv//eng)
Keyword
- biomarker
- bleeding
- ischemic heart disease
- Kardiologi
- Cardiology
Publication and Content Type
- ref (subject category)
- art (subject category)
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Lindholm, Daniel ...
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Hagström, Emil
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James, Stefan K, ...
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Becker, Richard ...
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Cannon, Christop ...
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Himmelmann, Ande ...
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Katus, Hugo A
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Maurer, Gerald
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López-Sendón, Jo ...
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Steg, Philippe G ...
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Storey, Robert F
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Siegbahn, Agneta ...
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Wallentin, Lars, ...
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- MEDICAL AND HEALTH SCIENCES
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MEDICAL AND HEAL ...
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and Clinical Medicin ...
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Uppsala University