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Effects of age, amy...
Effects of age, amyloid, sex, and APOE epsilon 4 on the CSF proteome in normal cognition
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Wesenhagen, K. E. J. (author)
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- Gobom, Johan (author)
- Gothenburg University,Göteborgs universitet,Institutionen för neurovetenskap och fysiologi, sektionen för psykiatri och neurokemi,Institute of Neuroscience and Physiology, Department of Psychiatry and Neurochemistry
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Bos, I. (author)
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Vos, S. J. B. (author)
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Martinez-Lage, P. (author)
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Popp, J. (author)
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Tsolaki, M. (author)
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Vandenberghe, R. (author)
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Freund-Levi, Y. (author)
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Verhey, F. (author)
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Lovestone, S. (author)
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Streffer, J. (author)
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Dobricic, V. (author)
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Bertram, L. (author)
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- Blennow, Kaj, 1958 (author)
- Gothenburg University,Göteborgs universitet,Institutionen för neurovetenskap och fysiologi, sektionen för psykiatri och neurokemi,Institute of Neuroscience and Physiology, Department of Psychiatry and Neurochemistry
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Pikkarainen, M. (author)
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Hallikainen, M. (author)
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Kuusisto, J. (author)
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Laakso, M. (author)
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Soininen, H. (author)
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Scheltens, P. (author)
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- Zetterberg, Henrik, 1973 (author)
- Gothenburg University,Göteborgs universitet,Institutionen för neurovetenskap och fysiologi, sektionen för psykiatri och neurokemi,Institute of Neuroscience and Physiology, Department of Psychiatry and Neurochemistry
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Teunissen, C. E. (author)
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Visser, P. J. (author)
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Tijms, B. M. (author)
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(creator_code:org_t)
- 2022-05-06
- 2022
- English.
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In: Alzheimer's & Dementia. - : Wiley. - 1552-5260 .- 1552-5279. ; 14:1
- Related links:
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https://gup.ub.gu.se...
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https://doi.org/10.1...
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Abstract
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- Introduction It is important to understand which biological processes change with aging, and how such changes are associated with increased Alzheimer's disease (AD) risk. We studied how cerebrospinal fluid (CSF) proteomics changed with age and tested if associations depended on amyloid status, sex, and apolipoprotein E sigma 4 genotype. Methods We included 277 cognitively intact individuals aged 46 to 89 years from Alzheimer's Disease Neuroimaging Initiative, European Medical Information Framework for Alzheimer's Disease Multimodal Biomarker Discovery, and Metabolic Syndrome in Men. In total, 1149 proteins were measured with liquid chromatography mass spectrometry with multiple reaction monitoring/Rules-Based Medicine, tandem mass tag mass spectrometry, and SOMAscan. We tested associations between age and protein levels in linear models and tested enrichment for Reactome pathways. Results Levels of 252 proteins increased with age independently of amyloid status. These proteins were associated with immune and signaling processes. Levels of 21 proteins decreased with older age exclusively in amyloid abnormal participants and these were enriched for extracellular matrix organization. Discussion We found amyloid-independent and -dependent CSF proteome changes with older age, perhaps representing physiological aging and early AD pathology.
Subject headings
- MEDICIN OCH HÄLSOVETENSKAP -- Medicinska och farmaceutiska grundvetenskaper -- Neurovetenskaper (hsv//swe)
- MEDICAL AND HEALTH SCIENCES -- Basic Medicine -- Neurosciences (hsv//eng)
- MEDICIN OCH HÄLSOVETENSKAP -- Klinisk medicin -- Psykiatri (hsv//swe)
- MEDICAL AND HEALTH SCIENCES -- Clinical Medicine -- Psychiatry (hsv//eng)
Keyword
- cerebrospinal-fluid
- alzheimers-disease
- biomarkers
- dementia
- Neurosciences & Neurology
Publication and Content Type
- ref (subject category)
- art (subject category)
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- By the author/editor
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Wesenhagen, K. E ...
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Gobom, Johan
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Bos, I.
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Vos, S. J. B.
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Martinez-Lage, P ...
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Popp, J.
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show more...
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Tsolaki, M.
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Vandenberghe, R.
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Freund-Levi, Y.
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Verhey, F.
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Lovestone, S.
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Streffer, J.
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Dobricic, V.
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Bertram, L.
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Blennow, Kaj, 19 ...
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Pikkarainen, M.
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Hallikainen, M.
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Kuusisto, J.
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Laakso, M.
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Soininen, H.
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Scheltens, P.
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Zetterberg, Henr ...
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Teunissen, C. E.
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Visser, P. J.
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Tijms, B. M.
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show less...
- About the subject
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- MEDICAL AND HEALTH SCIENCES
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MEDICAL AND HEAL ...
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and Basic Medicine
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and Neurosciences
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- MEDICAL AND HEALTH SCIENCES
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MEDICAL AND HEAL ...
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and Clinical Medicin ...
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and Psychiatry
- Articles in the publication
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Alzheimer's & De ...
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Alzheimer's & De ...
- By the university
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University of Gothenburg