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Atrial fibrillation genetic risk differentiates cardioembolic stroke from other stroke subtypes
- Pulit, S. L. (author)
- Weng, L. C. (author)
- McArdle, P. F. (author)
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- Trinquart, L. (author)
- Choi, S. H. (author)
- Mitchell, B. D. (author)
- Rosand, J. (author)
- de Bakker, P. I. W. (author)
- Benjamin, E. J. (author)
- Ellinor, P. T. (author)
- Kittner, S. J. (author)
- Lubitz, S. A. (author)
- Anderson, C. D. (author)
- Christophersen, I. E. (author)
- Rienstra, M. (author)
- Roselli, C. (author)
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- Geelhoed, B. (author)
- Barnard, J. (author)
- Lin, H. H. (author)
- Arking, D. E. (author)
- Smith, A. V. (author)
- Albert, C. M. (author)
- Chaffin, M. (author)
- Tucker, N. R. (author)
- Li, M. L. (author)
- Klarin, D. (author)
- Bihlmeyer, N. A. (author)
- Low, S. K. (author)
- Weeke, P. E. (author)
- Muller-Nurasyid, M. (author)
- Smith, J. G. (author)
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- Niemeijer, M. N. (author)
- Dorr, M. (author)
- Trompet, S. (author)
- Huffman, J. (author)
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- Malik, R. (author)
- Horimoto, Arvr (author)
- Perez, M. (author)
- Sinisalo, J. (author)
- Aeschbacher, S. (author)
- Theriault, S. (author)
- Yao, J. (author)
- Radmanesh, F. (author)
- Weiss, S. (author)
- Teumer, A. (author)
- Clauss, S. (author)
- Deo, R. (author)
- Rader, D. J. (author)
- Shah, S. (author)
- Sun, A. (author)
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- Hofman, A. (author)
- Franco, O. H. (author)
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- Lin, H. J. (author)
- Guo, X. Q. (author)
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- Kooperberg, C. (author)
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- Laurikka, J. (author)
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- Lee, T. H. (author)
- Chang, K. C. (author)
- Elkind, M. (author)
- Goldstein, L. (author)
- James, M. L. (author)
- Breteler, M. (author)
- O'Donnell, C. (author)
- Leys, D. (author)
- Carty, C. (author)
- Kidwell, C. (author)
- Olesen, J. (author)
- Sharma, P. (author)
- Rich, S. (author)
- Tatlisumak, T. (author)
- Happola, O. (author)
- Bijlenga, P. (author)
- Soriano, C. (author)
- Giralt, E. (author)
- Roquer, J. (author)
- Jimenez-Conde, J. (author)
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- Hardy, J. (author)
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- Mateusz, A. (author)
- Urbanik, A. (author)
- Dziedzic, T. (author)
- Jagiella, J. (author)
- Gasowski, J. (author)
- Wnuk, M. (author)
- Olszanecki, R. (author)
- Pera, J. (author)
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- Juchniewicz, K. J. (author)
- Levi, C. (author)
- Nyquist, P. (author)
- Cendes, I. (author)
- Cabral, N. (author)
- Franca, P. (author)
- Goncalves, A. (author)
- Keller, L. (author)
- Crisby, M. (author)
- Kostulas, K. (author)
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- Ahmadi, K. (author)
- Opherk, C. (author)
- Duering, M. (author)
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- Staals, J. (author)
- Burri, P. (author)
- Sadr-Nabavi, A. (author)
- Romero, J. (author)
- Biffi, A. (author)
- Anderson, C. (author)
- Falcone, G. (author)
- Brouwers, B. (author)
- Du, R. (author)
- Kourkoulis, C. (author)
- Battey, T. (author)
- Lubitz, S. (author)
- Mueller-Myhsok, B. (author)
- Meschia, J. (author)
- Brott, T. (author)
- Pichler, A. (author)
- Enzinger, C. (author)
- Schmidt, H. (author)
- Schmidt, R. (author)
- Seiler, S. (author)
- Blanton, S. (author)
- Yamada, Y. (author)
- Bersano, A. (author)
- Rundek, T. (author)
- Sacco, R. (author)
- Chan, Y. F. Y. (author)
- Gschwendtner, A. (author)
- Deng, Z. (author)
- Barr, T. (author)
- Gwinn, K. (author)
- Corriveau, R. (author)
- Singleton, A. (author)
- Waddy, S. (author)
- Launer, L. (author)
- Chen, C. (author)
- Le, K. E. (author)
- Lee, W. L. (author)
- Tan, E. K. (author)
- Olugbodi, A. (author)
- Rothwell, P. (author)
- Schilling, S. (author)
- Mok, V. (author)
- Lebedeva, E. (author)
- Jern, C. (author)
- Jood, K. (author)
- Olsson, S. (author)
- Kim, H. (author)
- Lee, C. (author)
- Kilarski, L. (author)
- Markus, H. (author)
- Peycke, J. (author)
- Bevan, S. (author)
- Sheu, W. (author)
- Chiou, H. Y. (author)
- Chern, J. (author)
- Giraldo, E. (author)
- Taqi, M. (author)
- Jain, V. (author)
- Lam, O. (author)
- Howard, G. (author)
- Woo, D. (author)
- Kittner, S. (author)
- Mitchell, B. (author)
- Cole, J. (author)
- O'Connell, J. (author)
- Milewicz, D. (author)
- Illoh, K. (author)
- Worrall, B. (author)
- Stine, C. (author)
- Karaszewski, B. (author)
- Werring, D. (author)
- Sofat, R. (author)
- Smalley, J. (author)
- Lindgren, A. (author)
- Hansen, B. (author)
- Norrving, B. (author)
- Smith, G. (author)
- Martin, J. J. (author)
- Thijs, V. (author)
- Klijn, K. (author)
- van't Hof, F. (author)
- Algra, A. (author)
- Macleod, M. (author)
- Perry, R. (author)
- Arnett, D. (author)
- Pezzini, A. (author)
- Padovani, A. (author)
- Cramer, S. (author)
- Fisher, M. (author)
- Saleheen, D. (author)
- Broderick, J. (author)
- Kissela, B. (author)
- Doney, A. (author)
- Sudlow, C. (author)
- Rannikmae, K. (author)
- Silliman, S. (author)
- McDonough, C. (author)
- Walters, M. (author)
- Nakagawa, K. (author)
- Chang, C. (author)
- Dobbins, M. (author)
- McArdle, P. (author)
- Chang, Y. C. (author)
- Brown, R. (author)
- Brown, D. (author)
- Holliday, E. (author)
- Kalaria, R. (author)
- Maguire, J. (author)
- Attia, J. (author)
- Farrall, M. (author)
- Giese, A. K. (author)
- Fornage, M. (author)
- Majersik, J. (author)
- Cushman, M. (author)
- Keene, K. (author)
- Bennett, S. (author)
- Tirschwell, D. (author)
- Psaty, B. (author)
- Reiner, A. (author)
- Longstreth, W. (author)
- Spence, D. (author)
- Montaner, J. (author)
- Fernandez-Cadenas, I. (author)
- Langefeld, C. (author)
- Bushnell, C. (author)
- Heitsch, L. (author)
- Lee, J. M. (author)
- Sheth, K. (author)
- Atrial Fibrillation Genetics Conso; Int Stroke Genetics, Consortium (author)
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- (creator_code:org_t)
- 2018-12-03
- 2018
- English.
- In: Neurology-Genetics. - : Ovid Technologies (Wolters Kluwer Health). - 2376-7839. ; 4:6
- Journal article (peer-reviewed)
Abstract
Subject headings
Close
- Objective We sought to assess whether genetic risk factors for atrial fibrillation (AF) can explain cardioembolic stroke risk. We evaluated genetic correlations between a previous genetic study of AF and AF in the presence of cardioembolic stroke using genome-wide genotypes from the Stroke Genetics Network (N = 3,190 AF cases, 3,000 cardioembolic stroke cases, and 28,026 referents). We tested whether a previously validated AF polygenic risk score (PRS) associated with cardioembolic and other stroke subtypes after accounting for AF clinical risk factors. We observed a strong correlation between previously reported genetic risk for AF, AF in the presence of stroke, and cardioembolic stroke (Pearson r = 0.77 and 0.76, respectively, across SNPs with p < 4.4 x 10(-4) in the previous AF meta-analysis). An AF PRS, adjusted for clinical AF risk factors, was associated with cardioembolic stroke (odds ratio [OR] per SD = 1.40, p = 1.45 x 10(-48)), explaining similar to 20% of the heritable component of cardioembolic stroke risk. The AF PRS was also associated with stroke of undetermined cause (OR per SD = 1.07,p = 0.004), but no other primary stroke subtypes (all p > 0.1). Genetic risk of AF is associated with cardioembolic stroke, independent of clinical risk factors. Studies are warranted to determine whether AF genetic risk can serve as a biomarker for strokes caused by AF.
Subject headings
- MEDICIN OCH HÄLSOVETENSKAP -- Medicinska och farmaceutiska grundvetenskaper -- Neurovetenskaper (hsv//swe)
- MEDICAL AND HEALTH SCIENCES -- Basic Medicine -- Neurosciences (hsv//eng)
Keyword
- ischemic-stroke
- causative classification
- lifetime risk
- epidemiology
- association
- prevention
- variants
- aspirin
- burden
- Neurosciences & Neurology
Publication and Content Type
- ref (subject category)
- art (subject category)
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- Pulit, S. L.
- Weng, L. C.
- McArdle, P. F.
- Trinquart, L.
- Choi, S. H.
- Mitchell, B. D.
- show more...
- Rosand, J.
- de Bakker, P. I. ...
- Benjamin, E. J.
- Ellinor, P. T.
- Kittner, S. J.
- Lubitz, S. A.
- Anderson, C. D.
- Christophersen, ...
- Rienstra, M.
- Roselli, C.
- Yin, X. Y.
- Geelhoed, B.
- Barnard, J.
- Lin, H. H.
- Arking, D. E.
- Smith, A. V.
- Albert, C. M.
- Chaffin, M.
- Tucker, N. R.
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- Klarin, D.
- Bihlmeyer, N. A.
- Low, S. K.
- Weeke, P. E.
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- Brody, J. A.
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- Radmanesh, F.
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- Lichtner, P.
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- Kahonen, M.
- Risch, L.
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- Peters, A.
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- Hernesniemi, J.
- Lindgren, C. M.
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- Langefeld, C.
- Bushnell, C.
- Heitsch, L.
- Lee, J. M.
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