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Sökning: onr:"swepub:oai:DiVA.org:uu-279627" > Early Life Origins ...

Early Life Origins of Lung Ageing : Early Life Exposures and Lung Function Decline in Adulthood in Two European Cohorts Aged 28-73 Years

Dratva, Julia (författare)
Swiss Trop & Publ Hlth Inst, Dept Epidemiol & Publ Hlth, Basel, Switzerland.;Univ Basel, Basel, Switzerland.
Zemp, Elisabeth (författare)
Swiss Trop & Publ Hlth Inst, Dept Epidemiol & Publ Hlth, Basel, Switzerland.;Univ Basel, Basel, Switzerland.
Dharmage, Shyamali C. (författare)
Univ Melbourne, Sch Populat & Global Hlth, Ctr Epidemiol & Biostat, Allergy & Lung Hlth Unit, Melbourne, Vic 3010, Australia.
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Accordini, Simone (författare)
Univ Verona, Dept Publ Hlth & Community Med, Unit Epidemiol & Med Stat, I-37100 Verona, Italy.
Burdet, Luc (författare)
Hop Intercantonal Broye, Payerne, Switzerland.
Gislason, Thorarinn (författare)
Landspitali Univ, Hosp Reykjavik, Dept Resp Med & Sleep, Reykjavik, Iceland.
Heinrich, Joachim (författare)
Helmholtz Ctr Munich, Natl Res Ctr Environm Hlth, Munich, Germany.;Univ Munich, Univ Hosp Munich, Inst & Outpatient Clin Occupat Social & Environm, Munich, Germany.;German Ctr Lung Res DZ, Munich, Germany.
Janson, Christer (författare)
Uppsala universitet,Lungmedicin och allergologi
Jarvis, Deborah (författare)
Univ London Imperial Coll Sci Technol & Med, Dept Publ Hlth Sci, London, England.
de Marco, Roberto (författare)
Univ Verona, Dept Publ Hlth & Community Med, Unit Epidemiol & Med Stat, I-37100 Verona, Italy.
Norbäck, Dan (författare)
Uppsala universitet,Arbets- och miljömedicin
Pons, Marco (författare)
Reg Hosp Lugano, Div Pulm Med, Lugano, Switzerland.
Real, Francisco Gomez (författare)
Univ Bergen, Dept Clin Sci, Bergen, Norway.;Haukeland Hosp, Dept Obstet & Gynaecol, N-5021 Bergen, Norway.
Sunyer, Jordi (författare)
Ctr Res Environm Epidemiol CREAL, Barcelona, Spain.
Villani, Simona (författare)
Univ Pavia, Fac Med, Dept Publ Hlth Neurosci Expt & Legal Med, Via Palestro 3, I-27100 Pavia, Italy.
Probst-Hensch, Nicole (författare)
Swiss Trop & Publ Hlth Inst, Dept Epidemiol & Publ Hlth, Basel, Switzerland.;Univ Basel, Basel, Switzerland.
Svanes, Cecilie (författare)
Univ Bergen, Ctr Int Hlth, Bergen Resp Res Grp, Bergen, Norway.;Haukeland Hosp, Dept Occupat Med, N-5021 Bergen, Norway.
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Swiss Trop & Publ Hlth Inst, Dept Epidemiol & Publ Hlth, Basel, Switzerland;Univ Basel, Basel, Switzerland. Univ Melbourne, Sch Populat & Global Hlth, Ctr Epidemiol & Biostat, Allergy & Lung Hlth Unit, Melbourne, Vic 3010, Australia. (creator_code:org_t)
2016-01-26
2016
Engelska.
Ingår i: PLOS ONE. - : Public Library of Science (PLoS). - 1932-6203. ; 11:1
Relaterad länk:
https://uu.diva-port... (primary) (Raw object)
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https://journals.plo...
https://urn.kb.se/re...
https://doi.org/10.1...
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  • Tidskriftsartikel (refereegranskat)
Abstract Ämnesord
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  • Objectives Early life environment is essential for lung growth and maximally attained lung function. Whether early life exposures impact on lung function decline in adulthood, an indicator of lung ageing, has scarcely been studied. Methods Spirometry data from two time points (follow-up time 9-11 years) and information on early life exposures, health and life-style were available from 12862 persons aged 28-73 years participating in the European population-based cohorts SAPALDIA (n = 5705) and ECRHS (n = 7157). The associations of early life exposures with lung function (FEV1) decline were analysed using mixed-effects linear regression. Results Early life exposures were significantly associated with FEV1 decline, with estimates almost as large as personal smoking. FEV1 declined more rapidly among subjects born during the winter season (adjusted difference in FEV1/year of follow-up [95% CI] -2.04ml [-3.29;-0.80]), of older mothers, (-1.82 ml [-3.14;-0.49]) of smoking mothers (-1.82ml [-3.30;-0.34] or with younger siblings (-2.61ml [-3.85;-1.38]). Less rapid FEV1-decline was found in subjects who had attended daycare (3.98ml [2.78; 5.18]), and indicated in subjects with pets in childhood (0.97ml [-0.16; 2.09]). High maternal age and maternal smoking appeared to potentiate effects of personal smoking. The effects were independent of asthma at any age. Conclusion Early life factors predicted lung function decline decades later, suggesting that some mechanisms related lung ageing may be established early in life. Early life programming of susceptibility to adult insults could be a possible pathway that should be explored further.

Ämnesord

MEDICIN OCH HÄLSOVETENSKAP  -- Klinisk medicin -- Lungmedicin och allergi (hsv//swe)
MEDICAL AND HEALTH SCIENCES  -- Clinical Medicine -- Respiratory Medicine and Allergy (hsv//eng)

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