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The long-term effec...
The long-term effect of isradipine in pindolol-treated patients.
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- Dahlöf, Björn, 1953 (författare)
- Gothenburg University,Göteborgs universitet,Medicinska institutionen,Department medicine
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- Andrén, Lennart, 1946 (författare)
- Gothenburg University,Göteborgs universitet,Medicinska institutionen,Department medicine
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- Eggertsen, Robert, 1948 (författare)
- Gothenburg University,Göteborgs universitet,Medicinska institutionen,Department medicine
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visa fler...
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- Jern, Sverker, 1954 (författare)
- Gothenburg University,Göteborgs universitet,Medicinska institutionen,Department medicine
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- SVensson, Anders (författare)
- Gothenburg University,Göteborgs universitet,Medicinska institutionen,Department medicine
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- Hansson, Lennart (författare)
- Gothenburg University,Göteborgs universitet,Medicinska institutionen,Department medicine
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visa färre...
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(creator_code:org_t)
- 1987
- 1987
- Engelska.
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Ingår i: Journal of hypertension. Supplement : official journal of the International Society of Hypertension. - 0952-1178. ; 5:5, s. S567-70
- Relaterad länk:
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https://gup.ub.gu.se...
Abstract
Ämnesord
Stäng
- The long-term efficacy of isradipine, a new dihydropyridine calcium antagonist with marked vascular selectivity, was evaluated in 17 patients with essential hypertension. All had a supine diastolic blood pressure of greater than 95 mmHg with 10 mg pindolol once daily. After a short-term, double-blind, dose-finding, crossover comparison with addition of isradipine or placebo twice daily, they continued on pindolol and their optimal dose of isradipine in a single-blind, long-term follow-up study. Eighteen patients were recruited but one male patient discontinued treatment after 2 weeks due to ankle oedema and will not be accounted for in the overall evaluation. There were 11 males and six females with a mean age of 56 +/- 10 years. In the short-term study on the optimal dose of isradipine (5.1 mg twice daily) blood pressure was lowered by 24/18 mmHg (P less than 0.001). No change in heart rate was seen despite the substantial drop in blood pressure. In the long-term study the patients were seen for a mean follow-up time of 12.5 months (range 4-17 months). After the longest follow-up time mean arterial pressure was 107.0 +/- 7.4 compared with 120.1 +/- 8.2 mmHg after placebo baseline [delta = 13 mmHg (11%), P less than 0.001, n = 17]. The heart rate was unchanged (delta = 0.2 beats/min, 95% confidence limits -3, +3), and so was ankle circumference (delta = 0.12 cm, 95% confidence interval, -1, +1). On the other hand, mean weight was reduced by 2 kg from 90 kg (P less than 0.05, n = 17).(ABSTRACT TRUNCATED AT 250 WORDS)
Ämnesord
- MEDICIN OCH HÄLSOVETENSKAP -- Klinisk medicin -- Allmänmedicin (hsv//swe)
- MEDICAL AND HEALTH SCIENCES -- Clinical Medicine -- General Practice (hsv//eng)
- MEDICIN OCH HÄLSOVETENSKAP -- Klinisk medicin (hsv//swe)
- MEDICAL AND HEALTH SCIENCES -- Clinical Medicine (hsv//eng)
Nyckelord
- Aged
- Body Weight
- drug effects
- Calcium Channel Blockers
- adverse effects
- therapeutic use
- Double-Blind Method
- Drug Therapy
- Combination
- Edema
- etiology
- Female
- Heart Rate
- drug effects
- Humans
- Hypertension
- drug therapy
- Isradipine
- Male
- Middle Aged
- Pindolol
- administration & dosage
- Pyridines
- adverse effects
- therapeutic use
Publikations- och innehållstyp
- ref (ämneskategori)
- art (ämneskategori)
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