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Rotavirus infection...
Rotavirus infection is not associated with small intestinal fluid secretion in the adult mouse.
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- Kordasti, Shirin, 1975 (author)
- Gothenburg University,Göteborgs universitet,Institutionen för neurovetenskap och fysiologi, sektionen för fysiologi,Institute of Neuroscience and Physiology, Department of Physiology
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Istrate, Claudia (author)
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Banasaz, Mahanez (author)
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- Rottenberg, Martin (author)
- Karolinska Institutet
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- Sjövall, Henrik, 1954 (author)
- Gothenburg University,Göteborgs universitet,Institutionen för medicin, avdelningen för invärtesmedicin,Institute of Medicine, Department of Internal Medicine
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- Lundgren, Ove, 1937 (author)
- Gothenburg University,Göteborgs universitet,Institutionen för neurovetenskap och fysiologi, sektionen för fysiologi,Institute of Neuroscience and Physiology, Department of Physiology
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- Svensson, Lennart, 1954- (author)
- Linköpings universitet,Hälsouniversitetet,Molekylär virologi
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(creator_code:org_t)
- 2006
- 2006
- English.
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In: Journal of virology. - 0022-538X .- 1098-5514. ; 80:22, s. 11355-61
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Abstract
Subject headings
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- In contrast to humans, adult but not infant small animals are resistant to rotavirus diarrhea. The pathophysiological mechanism behind this age-restricted diarrhea is currently unresolved, and this question was investigated by studying the secretory state of the small intestines of adult mice infected with rotavirus. Immunohistochemistry and histological examinations revealed that rotavirus (strain EDIM) infects all parts of the small intestines of adult mice, with significant numbers of infected cells in the ilea at 2 and 4 days postinfection. Furthermore, quantitative PCR revealed that 100-fold more viral RNA was produced in the ilea than in the jejuna or duodena of adult mice. In vitro perfusion experiments of the small intestine did not reveal any significant changes in net fluid secretion among mice infected for 3 days or 4 days or in those that were noninfected (37 +/- 9 microl . h(-1) . cm(-1), 22 +/- 13 microl . h(-1) . cm(-1), and 33 +/- 6 microl . h(-1) . cm(-1), respectively) or in transmucosal potential difference (4.0 +/- 0.3 mV versus 3.9 +/- 0.4 mV), a marker for active chloride secretion, between control and rotavirus-infected mice. In vivo experiments also did not show any differences in potential difference between uninfected and infected small intestines. Furthermore, no significant differences in weight between infected and uninfected small intestines were found, nor were any differences in fecal output observed between infected and control mice. Altogether, these data suggest that rotavirus infection is not sufficient to stimulate chloride and water secretion from the small intestines of adult mice.
Subject headings
- MEDICIN OCH HÄLSOVETENSKAP -- Medicinska och farmaceutiska grundvetenskaper -- Mikrobiologi inom det medicinska området (hsv//swe)
- MEDICAL AND HEALTH SCIENCES -- Basic Medicine -- Microbiology in the medical area (hsv//eng)
- MEDICIN OCH HÄLSOVETENSKAP -- Medicinska och farmaceutiska grundvetenskaper -- Fysiologi (hsv//swe)
- MEDICAL AND HEALTH SCIENCES -- Basic Medicine -- Physiology (hsv//eng)
Keyword
- Animals
- Body Fluids
- secretion
- Chlorides
- metabolism
- Disease Models
- Animal
- Duodenum
- secretion
- virology
- Feces
- virology
- Gastrointestinal Motility
- Histocytochemistry
- Ileum
- secretion
- virology
- Immunohistochemistry
- Intestinal Mucosa
- secretion
- Intestine
- Small
- pathology
- physiopathology
- secretion
- virology
- Jejunum
- secretion
- virology
- Mice
- Mice
- Inbred BALB C
- Organ Size
- RNA
- Viral
- analysis
- Rotavirus Infections
- physiopathology
- virology
- MEDICINE
Publication and Content Type
- ref (subject category)
- art (subject category)
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