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Dual Antithrombotic Therapy with Dabigatran after PCI in Atrial Fibrillation.

Cannon, Christopher P. (författare)
Baim Institute for Clinical Research, USA; Brigham and Women’s Hospital, Heart and Vascular Center, USA; Harvard Medical School, USA,Baim Inst Clin Res, 930 Commonwealth Ave, Boston, MA 02215 USA.;Brigham & Womens Hosp, Heart & Vasc Ctr, 75 Francis St, Boston, MA 02115 USA.;Harvard Med Sch, Boston, MA USA.
Bhatt, Deepak L. (författare)
Brigham and Women’s Hospital, Heart and Vascular Center, USA; Harvard Medical School, USA,Brigham & Womens Hosp, Heart & Vasc Ctr, 75 Francis St, Boston, MA 02115 USA.;Harvard Med Sch, Boston, MA USA.
Oldgren, Jonas, 1964- (författare)
Uppsala universitet,Kardiologi,Uppsala kliniska forskningscentrum (UCR),Uppsala Clinical Research Center and Department of Medical Sciences, Uppsala University, Uppsala, Sweden
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Lip, Gregory Y. H. (författare)
Institute of Cardiovascular Sciences, University of Birmingham, Birmingham, UK,Univ Birmingham, Inst Cardiovasc Sci, Birmingham, W Midlands, England.
Ellis, Stephen G. (författare)
Cleveland Clin, Cleveland, OH 44106 USA.
Kimura, Takeshi (författare)
Kyoto University, Department of Cardiovascular Medicine, Kyoto, Japan,Kyoto Univ, Dept Cardiovasc Med, Kyoto, Japan.
Maeng, Michael (författare)
Aarhus University Hospital, Skejby, Denmark,Aarhus Univ Hosp, Skejby, Denmark.,St Antonius Hosp, Nieuwegein, Netherlands.,St. Antonius Ziekenhuis, Nieuwegein, Netherlands
Merkely, Bela (författare)
University Heart and Vascular Center, Budapest, Hungary,Univ Heart & Vasc Ctr, Budapest, Hungary.
Zeymer, Uwe (författare)
Klinikum der Stadt Ludwigshafen am Rhein, Medizinische Klinik B, Ludwigshafen, Germany
Gropper, Savion (författare)
Boehringer Ingelheim GmbH & Co KG, Ingelheim, Germany.
Nordaby, Matias (författare)
Boehringer Ingelheim GmbH & Co KG, Ingelheim, Germany.
Kleine, Eva (författare)
Boehringer Ingelheim GmbH & Co KG, Ingelheim, Germany.
Harper, Ruth (författare)
Boehringer Ingelheim GmbH & Co KG, Bracknell, Berks, England.
Manassie, Jenny (författare)
Boehringer Ingelheim GmbH & Co KG, Bracknell, Berks, England.
Januzzi, James L. (författare)
Baim Institute for Clinical Research, USA; Cardiology Division, Massachusetts General Hospital, USA; Harvard Medical School, USA,Baim Inst Clin Res, 930 Commonwealth Ave, Boston, MA 02215 USA.;Harvard Med Sch, Boston, MA USA.;Massachusetts Gen Hosp, Div Cardiol, Boston, MA 02114 USA.
Ten Berg, Jurrien M. (författare)
St. Antonius Ziekenhuis, Nieuwegein, Netherlands
Steg, P. Gabriel (författare)
Imperial College, London, London, UK,Imperial Coll, London, England.;Univ Paris Diderot, French Alliance Cardiovasc Trials, F CRIN Network, DHU FIRE,INSERM,Unite 1148, Paris, France.;Hop Bichat Assistance Publ, Paris, France.
Hohnloser, Stefan H. (författare)
Johann Wolfgang Goethe University, Department of Medicine, Division of Cardiology, Frankfurt am Main, Germany,Goethe Univ Frankfurt, Dept Med, Div Cardiol, Frankfurt, Germany.
Swahn, Eva, 1949- (bidragsgivare)
Linköpings universitet,Avdelningen för kardiovaskulär medicin,Medicinska fakulteten,Region Östergötland, Kardiologiska kliniken US,RE-DUAL PCI Steering Committee and Investigators
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Baim Institute for Clinical Research, USA; Brigham and Women’s Hospital, Heart and Vascular Center, USA; Harvard Medical School, USA Baim Inst Clin Res, 930 Commonwealth Ave, Boston, MA 02215 USA;Brigham & Womens Hosp, Heart & Vasc Ctr, 75 Francis St, Boston, MA 02115 USA.;Harvard Med Sch, Boston, MA USA. (creator_code:org_t)
Massachusetts Medical Society, 2017
2017
Engelska.
Ingår i: New England Journal of Medicine. - : Massachusetts Medical Society. - 0028-4793 .- 1533-4406. ; 377:16, s. 1513-1524
Relaterad länk:
https://liu.diva-por... (primary) (Raw object)
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https://urn.kb.se/re...
https://doi.org/10.1...
https://urn.kb.se/re...
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  • Tidskriftsartikel (refereegranskat)
Abstract Ämnesord
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  • BACKGROUND: Triple antithrombotic therapy with warfarin plus two antiplatelet agents is the standard of care after percutaneous coronary intervention (PCI) for patients with atrial fibrillation, but this therapy is associated with a high risk of bleeding.METHODS: inhibitor (clopidogrel or ticagrelor) and no aspirin (110-mg and 150-mg dual-therapy groups). Outside the United States, elderly patients (≥80 years of age; ≥70 years of age in Japan) were randomly assigned to the 110-mg dual-therapy group or the triple-therapy group. The primary end point was a major or clinically relevant nonmajor bleeding event during follow-up (mean follow-up, 14 months). The trial also tested for the noninferiority of dual therapy with dabigatran (both doses combined) to triple therapy with warfarin with respect to the incidence of a composite efficacy end point of thromboembolic events (myocardial infarction, stroke, or systemic embolism), death, or unplanned revascularization.RESULTS: The incidence of the primary end point was 15.4% in the 110-mg dual-therapy group as compared with 26.9% in the triple-therapy group (hazard ratio, 0.52; 95% confidence interval [CI], 0.42 to 0.63; P<0.001 for noninferiority; P<0.001 for superiority) and 20.2% in the 150-mg dual-therapy group as compared with 25.7% in the corresponding triple-therapy group, which did not include elderly patients outside the United States (hazard ratio, 0.72; 95% CI, 0.58 to 0.88; P<0.001 for noninferiority). The incidence of the composite efficacy end point was 13.7% in the two dual-therapy groups combined as compared with 13.4% in the triple-therapy group (hazard ratio, 1.04; 95% CI, 0.84 to 1.29; P=0.005 for noninferiority). The rate of serious adverse events did not differ significantly among the groups.CONCLUSIONS: inhibitor, and aspirin. Dual therapy was noninferior to triple therapy with respect to the risk of thromboembolic events. (Funded by Boehringer Ingelheim; RE-DUAL PCI ClinicalTrials.gov number, NCT02164864)

Ämnesord

MEDICIN OCH HÄLSOVETENSKAP  -- Klinisk medicin -- Kardiologi (hsv//swe)
MEDICAL AND HEALTH SCIENCES  -- Clinical Medicine -- Cardiac and Cardiovascular Systems (hsv//eng)

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