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Sökning: onr:"swepub:oai:DiVA.org:uu-518188" > Multimodal classifi...

Multimodal classification of molecular subtypes in pediatric acute lymphoblastic leukemia

Krali, Olga (författare)
Uppsala University,Uppsala universitet,Molekylär precisionsmedicin,Science for Life Laboratory, SciLifeLab,Department of Medical Sciences, Molecular Precision Medicine and Science for Life Laboratory, Uppsala University, Uppsala, Sweden
Marincevic-Zuniga, Yanara (författare)
Uppsala University,Uppsala universitet,Molekylär precisionsmedicin,Science for Life Laboratory, SciLifeLab,Department of Medical Sciences, Molecular Precision Medicine and Science for Life Laboratory, Uppsala University, Uppsala, Sweden
Arvidsson, Gustav (författare)
Uppsala University,Uppsala universitet,Molekylär precisionsmedicin,Science for Life Laboratory, SciLifeLab,Department of Medical Sciences, Molecular Precision Medicine and Science for Life Laboratory, Uppsala University, Uppsala, Sweden
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Enblad, Anna Pia (författare)
Uppsala University,Uppsala universitet,Molekylär precisionsmedicin,Science for Life Laboratory, SciLifeLab,Barnonkologisk och neurologisk forskning,Department of Medical Sciences, Molecular Precision Medicine and Science for Life Laboratory, Uppsala University, Uppsala, Sweden; Department of Women’s and Children’s Health, Uppsala University, Uppsala, Sweden
Lundmark, Anders (författare)
Uppsala University,Uppsala universitet,Molekylär precisionsmedicin,Science for Life Laboratory, SciLifeLab,Department of Medical Sciences, Molecular Precision Medicine and Science for Life Laboratory, Uppsala University, Uppsala, Sweden
Sayyab, Shumaila (författare)
Uppsala University,Uppsala universitet,Molekylär precisionsmedicin,Science for Life Laboratory, SciLifeLab,Department of Medical Sciences, Molecular Precision Medicine and Science for Life Laboratory, Uppsala University, Uppsala, Sweden
Zachariadis, Vasilios (författare)
Karolinska Institute,Department of Oncology-Pathology, Karolinska Institutet, Stockholm, Sweden
Heinäniemi, Merja (författare)
Institute of Biomedicine, School of Medicine, University of Eastern Finland, Kuopio, Finland
Suhonen, Janne (författare)
Institute of Biomedicine, School of Medicine, University of Eastern Finland, Kuopio, Finland
Oksa, Laura (författare)
Tampere Center for Child, Adolescent and Maternal Health Research, Faculty of Medicine and Health Technology, Tampere University, Tampere, Finland; Tampere University Hospital, Tays Cancer Center, Tampere, Finland,Tampere University Hospital
Vepsäläinen, Kaisa (författare)
Department of Pediatrics, Kuopio University Hospital, Kuopio, Finland
Öfverholm, Ingegerd (författare)
Karolinska Institute,Department of Oncology-Pathology, Karolinska Institutet, Stockholm, Sweden; Department of Molecular Medicine and Surgery and Center for Molecular Medicine, Karolinska Institutet, Stockholm, Sweden; Department of Clinical Genetics, Karolinska University Hospital, Stockholm, Sweden
Barbany, Gisela (författare)
Karolinska Institute,Karolinska Institutet,Department of Molecular Medicine and Surgery and Center for Molecular Medicine, Karolinska Institutet, Stockholm, Sweden; Department of Clinical Genetics, Karolinska University Hospital, Stockholm, Sweden
Nordgren, Ann (författare)
Karolinska Institute,Karolinska Institutet,Department of Molecular Medicine and Surgery and Center for Molecular Medicine, Karolinska Institutet, Stockholm, Sweden; Department of Clinical Genetics, Karolinska University Hospital, Stockholm, Sweden
Lilljebjörn, Henrik (författare)
Lund University,Lunds universitet,Avdelningen för klinisk genetik,Institutionen för laboratoriemedicin,Medicinska fakulteten,Translationella genomiska och funktionella studier av leukemi,Forskargrupper vid Lunds universitet,LUCC: Lunds universitets cancercentrum,Övriga starka forskningsmiljöer,Division of Clinical Genetics,Department of Laboratory Medicine,Faculty of Medicine,Translational Genomic and Functional Studies of Leukemia,Lund University Research Groups,LUCC: Lund University Cancer Centre,Other Strong Research Environments,Division of Clinical Genetics, Dept. of Laboratory Medicine, Lund University, Lund, Sweden
Fioretos, Thoas (författare)
Lund University,Lunds universitet,Avdelningen för klinisk genetik,Institutionen för laboratoriemedicin,Medicinska fakulteten,Translationella genomiska och funktionella studier av leukemi,Forskargrupper vid Lunds universitet,LUCC: Lunds universitets cancercentrum,Övriga starka forskningsmiljöer,LTH profilområde: Teknik för hälsa,LTH profilområden,Lunds Tekniska Högskola,Division of Clinical Genetics,Department of Laboratory Medicine,Faculty of Medicine,Translational Genomic and Functional Studies of Leukemia,Lund University Research Groups,LUCC: Lund University Cancer Centre,Other Strong Research Environments,LTH Profile Area: Engineering Health,LTH Profile areas,Faculty of Engineering, LTH,Division of Clinical Genetics, Dept. of Laboratory Medicine, Lund University, Lund, Sweden
Madsen, Hans O (författare)
Department of Clinical Immunology, Copenhagen University Hospital Rigshospitalet, Copenhagen, Denmark
Marquart, Hanne Vibeke (författare)
Department of Clinical Immunology, Copenhagen University Hospital Rigshospitalet, Copenhagen, Denmark; Department of Clinical Medicine, Faculty of Health and Medical Sciences, University of Copenhagen, Copenhagen, Denmark,University of Copenhagen
Flaegstad, Trond (författare)
University Hospital of North Norway,Department of Pediatrics, Tromsø University and University Hospital, Tromsø, Norway; For the Nordic Society of Pediatric Hematology and Oncology (NOPHO), Stockholm, Sweden
Forestier, Erik (författare)
Umeå universitet,Umeå University,Medicinsk och klinisk genetik,For the Nordic Society of Pediatric Hematology and Oncology (NOPHO), Stockholm, Sweden
Jónsson, Ólafur G (författare)
National University Hospital of Iceland,For the Nordic Society of Pediatric Hematology and Oncology (NOPHO), Stockholm, Sweden; Pediatric Hematology-Oncology, Children’s Hospital, Barnaspitali Hringsins, Landspitali University Hospital, Reykjavik, Iceland
Kanerva, Jukka (författare)
For the Nordic Society of Pediatric Hematology and Oncology (NOPHO), Stockholm, Sweden; New Children’s Hospital, Helsinki University Central Hospital and University of Helsinki, Helsinki, Finland
Lohi, Olli (författare)
Tampere Center for Child, Adolescent and Maternal Health Research, Faculty of Medicine and Health Technology, Tampere University, Tampere, Finland; Tampere University Hospital, Tays Cancer Center, Tampere, Finland; For the Nordic Society of Pediatric Hematology and Oncology (NOPHO), Stockholm, Sweden,Tampere University Hospital
Norén-Nyström, Ulrika (författare)
Umeå universitet,Umeå University,Pediatrik,For the Nordic Society of Pediatric Hematology and Oncology (NOPHO), Stockholm, Sweden
Schmiegelow, Kjeld (författare)
Copenhagen University Hospital,For the Nordic Society of Pediatric Hematology and Oncology (NOPHO), Stockholm, Sweden; Pediatrics and Adolescent Medicine, Rigshospitalet, and the Medical Faculty, Institute of Clinical Medicine, University of Copenhagen, Copenhagen, Denmark
Harila, Arja (författare)
Uppsala University,Uppsala universitet,Barnonkologisk och neurologisk forskning,Department of Women’s and Children’s Health, Uppsala University, Uppsala, Sweden; For the Nordic Society of Pediatric Hematology and Oncology (NOPHO), Stockholm, Sweden
Heyman, Mats (författare)
For the Nordic Society of Pediatric Hematology and Oncology (NOPHO), Stockholm, Sweden; Childhood Cancer Research Unit, Karolinska Institutet, Astrid Lindgren Children’s Hospital, Karolinska University Hospital, Stockholm, Sweden
Lönnerholm, Gudmar, 1941- (författare)
Uppsala University,Uppsala universitet,Barnonkologisk och neurologisk forskning,Department of Women’s and Children’s Health, Uppsala University, Uppsala, Sweden; For the Nordic Society of Pediatric Hematology and Oncology (NOPHO), Stockholm, Sweden
Syvänen, Ann-Christine, 1950- (författare)
Uppsala University,Uppsala universitet,Molekylär precisionsmedicin,Science for Life Laboratory, SciLifeLab,Department of Medical Sciences, Molecular Precision Medicine and Science for Life Laboratory, Uppsala University, Uppsala, Sweden
Nordlund, Jessica (författare)
Uppsala University,Uppsala universitet,Molekylär precisionsmedicin,Science for Life Laboratory, SciLifeLab,Department of Medical Sciences, Molecular Precision Medicine and Science for Life Laboratory, Uppsala University, Uppsala, Sweden
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 (creator_code:org_t)
Springer Nature, 2023
2023
Engelska.
Ingår i: npj Precision Oncology. - : Springer Nature. - 2397-768X. ; 7:1
  • Tidskriftsartikel (refereegranskat)
Abstract Ämnesord
Stäng  
  • Genomic analyses have redefined the molecular subgrouping of pediatric acute lymphoblastic leukemia (ALL). Molecular subgroups guide risk-stratification and targeted therapies, but outcomes of recently identified subtypes are often unclear, owing to limited cases with comprehensive profiling and cross-protocol studies. We developed a machine learning tool (ALLIUM) for the molecular subclassification of ALL in retrospective cohorts as well as for up-front diagnostics. ALLIUM uses DNA methylation and gene expression data from 1131 Nordic ALL patients to predict 17 ALL subtypes with high accuracy. ALLIUM was used to revise and verify the molecular subtype of 281 B-cell precursor ALL (BCP-ALL) cases with previously undefined molecular phenotype, resulting in a single revised subtype for 81.5% of these cases. Our study shows the power of combining DNA methylation and gene expression data for resolving ALL subtypes and provides a comprehensive population-based retrospective cohort study of molecular subtype frequencies in the Nordic countries.

Ämnesord

MEDICIN OCH HÄLSOVETENSKAP  -- Klinisk medicin -- Cancer och onkologi (hsv//swe)
MEDICAL AND HEALTH SCIENCES  -- Clinical Medicine -- Cancer and Oncology (hsv//eng)
MEDICIN OCH HÄLSOVETENSKAP  -- Klinisk medicin -- Hematologi (hsv//swe)
MEDICAL AND HEALTH SCIENCES  -- Clinical Medicine -- Hematology (hsv//eng)
MEDICIN OCH HÄLSOVETENSKAP  -- Medicinska och farmaceutiska grundvetenskaper -- Medicinsk genetik (hsv//swe)
MEDICAL AND HEALTH SCIENCES  -- Basic Medicine -- Medical Genetics (hsv//eng)

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