Rolofylline, an adenosine A1-receptor antagonist, in acute heart failure.

• Worsening renal function, which is associated with adverse outcomes, often develops in patients with acute heart failure. Experimental and clinical studies suggest that counterregulatory responses mediated by adenosine may be involved. We tested the hypothesis that the use of rolofylline, an adenosine A1-receptor antagonist, would improve dyspnea, reduce the risk of worsening renal function, and lead to a more favorable clinical course in patients with acute heart failure.

Subject headings

MEDICIN OCH HÄLSOVETENSKAP  -- Klinisk medicin -- Dermatologi och venereologi (hsv//swe)

MEDICAL AND HEALTH SCIENCES  -- Clinical Medicine -- Dermatology and Venereal Diseases (hsv//eng)

Keyword

Acute Disease

Adenosine A1 Receptor Antagonists

Aged

Diuretics

adverse effects

therapeutic use

Double-Blind Method

Female

Heart Failure

drug therapy

mortality

Humans

Intention to Treat Analysis

Kaplan-Meier Estimate

Male

Odds Ratio

Patient Readmission

Proportional Hazards Models

Risk

Treatment Failure

Xanthines

adverse effects

therapeutic use

Publication and Content Type

ref (subject category)

art (subject category)