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Sökning: onr:"swepub:oai:lup.lub.lu.se:8af8d8ac-4af4-4858-971a-b703405185fc" > Prognostic value of...

Prognostic value of Alzheimer’s biomarkers in mild cognitive impairment : the effect of age at onset

Altomare, Daniele (författare)
University of Geneva,Geneva University Hospital,Univ Geneva, Lab Neuroimaging Aging LANVIE, Geneva, Switzerland;Memory Clin, Univ Hosp Geneva, Geneva, Switzerland
Ferrari, Clarissa (författare)
Centro San Giovanni di Dio Fatebenefratelli,IRCCS Ist Ctr San Giovanni di Dio Fatebenefratell, Serv Stat, Via Pilastroni 4, I-25125 Brescia, Italy
Caroli, Anna (författare)
Mario Negri Institute for Pharmacological Research,Ist Ric Farmacol Mario Negri IRCCS, Med Imaging Unit, Bergamo, Italy
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Galluzzi, Samantha (författare)
Centro San Giovanni di Dio Fatebenefratelli,IRCCS Ist Ctr San Giovanni di Dio Fatebenefratell, LANE, Brescia, Italy
Prestia, Annapaola (författare)
Centro San Giovanni di Dio Fatebenefratelli,IRCCS Ist Ctr San Giovanni di Dio Fatebenefratell, LANE, Brescia, Italy
van der Flier, Wiesje M. (författare)
Amsterdam UMC - Vrije Universiteit Amsterdam,Vrije Universiteit Amsterdam,Vrije Univ Amsterdam, Amsterdam UMC, Amsterdam Neurosci, Alzheimer Ctr Amsterdam,Dept Neurol, Amsterdam, Netherlands;Vrije Univ Amsterdam, Amsterdam UMC, Amsterdam Neurosci, Dept Epidemiol & Biostat, Amsterdam, Netherlands
Ossenkoppele, Rik (författare)
Lund University,Lunds universitet,Klinisk minnesforskning,Forskargrupper vid Lunds universitet,Clinical Memory Research,Lund University Research Groups,Amsterdam UMC - Vrije Universiteit Amsterdam,Vrije Univ Amsterdam, Amsterdam UMC, Amsterdam Neurosci, Alzheimer Ctr Amsterdam,Dept Neurol, Amsterdam, Netherlands;Vrije Univ Amsterdam, Amsterdam UMC, Amsterdam Neurosci, Dept Radiol & Nucl Med, Amsterdam, Netherlands;Lund Univ, Dept Clin Sci, Clin Memory Res Unit, Malmo, Sweden
Van Berckel, Bart (författare)
Amsterdam UMC - Vrije Universiteit Amsterdam,Vrije Univ Amsterdam, Amsterdam UMC, Amsterdam Neurosci, Alzheimer Ctr Amsterdam,Dept Neurol, Amsterdam, Netherlands;Vrije Univ Amsterdam, Amsterdam UMC, Amsterdam Neurosci, Dept Radiol & Nucl Med, Amsterdam, Netherlands
Barkhof, Frederik (författare)
University College London,Amsterdam UMC - Vrije Universiteit Amsterdam,Vrije Universiteit Amsterdam,Vrije Univ Amsterdam, Amsterdam UMC, Amsterdam Neurosci, Dept Radiol & Nucl Med, Amsterdam, Netherlands;UCL, Inst Neurol, London, England;UCL, Inst Healthcare Engn, London, England
Teunissen, Charlotte E. (författare)
Amsterdam UMC - Vrije Universiteit Amsterdam,Vrije Univ Amsterdam, Amsterdam UMC, Amsterdam Neurosci, Dept Clin Chem,Neurochem Lab, Amsterdam, Netherlands
Wall, Anders (författare)
Uppsala universitet,Uppsala University,Radiologi
Carter, Stephen F. (författare)
Karolinska Institute,University of Manchester,Karolinska Inst, Alzheimer Neurobiol Ctr, Stockholm, Sweden;Univ Manchester, Wolfson Mol Imaging Ctr, Manchester, Lancs, England
Schöll, Michael (författare)
Gothenburg University,Göteborgs universitet,University of Gothenburg,Lund University,Lunds universitet,Klinisk minnesforskning,Forskargrupper vid Lunds universitet,Clinical Memory Research,Lund University Research Groups,University College London,Lund Univ, Dept Clin Sci, Clin Memory Res Unit, Malmo, Sweden;Univ Gothenburg, Dept Psychiat & Neurochem, Wallenberg Ctr Mol & Translat Med, Gothenburg, Sweden;UCL, Inst Neurol, Dept Neurodegenerat Dis, Dementia Res Ctr, Queen Sq, London, England,Wallenberg Centre for Molecular and Translational Medicine,Institutionen för neurovetenskap och fysiologi, sektionen för psykiatri och neurokemi,Institute of Neuroscience and Physiology, Department of Psychiatry and Neurochemistry
Choo, Il Han (författare)
Karolinska Institute,Chosun University,Karolinska Inst, Alzheimer Neurobiol Ctr, Stockholm, Sweden;Chosun Univ, Sch Med, Dept Neuropsychiat, Gwangju, South Korea
Grimmer, Timo (författare)
Technical University of Munich,Tech Univ Munich, Dept Psychiat & Psychotherapy, Klinikum Rechts Isar, Munich, Germany
Redolfi, Alberto (författare)
Centro San Giovanni di Dio Fatebenefratelli,IRCCS Ist Ctr San Giovanni di Dio Fatebenefratell, LANE, Brescia, Italy
Nordberg, Agneta (författare)
Karolinska Institutet,Karolinska Institute,Karolinska University Hospital,Karolinska Inst, Ctr Alzheimer Res, Dept Neurobiol Care Sci & Soc, Div Clin Geriatr, Stockholm, Sweden;Karolinska Univ Hosp, Aging Theme, Stockholm, Sweden
Scheltens, Philip (författare)
Amsterdam UMC - Vrije Universiteit Amsterdam,Vrije Univ Amsterdam, Amsterdam UMC, Amsterdam Neurosci, Alzheimer Ctr Amsterdam,Dept Neurol, Amsterdam, Netherlands
Drzezga, Alexander (författare)
University of Cologne,Univ Cologne, Dept Nucl Med, Cologne, Germany
Frisoni, Giovanni B (författare)
Geneva University Hospital,Centro San Giovanni di Dio Fatebenefratelli,Univ Geneva, Lab Neuroimaging Aging LANVIE, Geneva, Switzerland;IRCCS Ist Ctr San Giovanni di Dio Fatebenefratell, LANE, Brescia, Italy;Memory Clin, Univ Hosp Geneva, Geneva, Switzerland
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 (creator_code:org_t)
 
2019-07-02
2019
Engelska 10 s.
Ingår i: Journal of Neurology. - : Springer Science and Business Media LLC. - 0340-5354 .- 1432-1459. ; 266:10, s. 2535-2545
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  • Tidskriftsartikel (refereegranskat)
Abstract Ämnesord
Stäng  
  • Objective: The aim of this study is to assess the impact of age at onset on the prognostic value of Alzheimer’s biomarkers in a large sample of patients with mild cognitive impairment (MCI). Methods: We measured Aβ42, t-tau, hippocampal volume on magnetic resonance imaging (MRI) and cortical metabolism on fluorodeoxyglucose–positron emission tomography (FDG-PET) in 188 MCI patients followed for at least 1 year. We categorised patients into earlier and later onset (EO/LO). Receiver operating characteristic curves and corresponding areas under the curve (AUCs) were performed to assess and compar the biomarker prognostic performances in EO and LO groups. Linear Model was adopted for estimating the time-to-progression in relation with earlier/later onset MCI groups and biomarkers. Results: In earlier onset patients, all the assessed biomarkers were able to predict cognitive decline (p < 0.05), with FDG-PET showing the best performance. In later onset patients, all biomarkers but t-tau predicted cognitive decline (p < 0.05). Moreover, FDG-PET alone in earlier onset patients showed a higher prognostic value than the one resulting from the combination of all the biomarkers in later onset patients (earlier onset AUC 0.935 vs later onset AUC 0.753, p < 0.001). Finally, FDG-PET showed a different prognostic value between earlier and later onset patients (p = 0.040) in time-to-progression allowing an estimate of the time free from disease. Discussion: FDG-PET may represent the most universal tool for the establishment of a prognosis in MCI patients and may be used for obtaining an onset-related estimate of the time free from disease.

Ämnesord

MEDICIN OCH HÄLSOVETENSKAP  -- Klinisk medicin -- Neurologi (hsv//swe)
MEDICAL AND HEALTH SCIENCES  -- Clinical Medicine -- Neurology (hsv//eng)
MEDICIN OCH HÄLSOVETENSKAP  -- Medicinska och farmaceutiska grundvetenskaper -- Neurovetenskaper (hsv//swe)
MEDICAL AND HEALTH SCIENCES  -- Basic Medicine -- Neurosciences (hsv//eng)

Nyckelord

Alzheimer
Biomarkers
Cognition
FDG-PET
Imaging
Alzheimer

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