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Clinical and analyt...
Clinical and analytical comparison of six Simoa assays for plasma P-tau isoforms P-tau181, P-tau217, and P-tau231.
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Bayoumy, Sherif (author)
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Verberk, Inge M W (author)
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den Dulk, Ben (author)
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Hussainali, Zulaiga (author)
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Zwan, Marissa (author)
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van der Flier, Wiesje M (author)
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- Ashton, Nicholas J. (author)
- Gothenburg University,Göteborgs universitet,Institutionen för neurovetenskap och fysiologi, sektionen för psykiatri och neurokemi,Institute of Neuroscience and Physiology, Department of Psychiatry and Neurochemistry
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- Zetterberg, Henrik, 1973 (author)
- Gothenburg University,Göteborgs universitet,Institutionen för neurovetenskap och fysiologi, sektionen för psykiatri och neurokemi,Institute of Neuroscience and Physiology, Department of Psychiatry and Neurochemistry
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- Blennow, Kaj, 1958 (author)
- Gothenburg University,Göteborgs universitet,Institutionen för neurovetenskap och fysiologi, sektionen för psykiatri och neurokemi,Institute of Neuroscience and Physiology, Department of Psychiatry and Neurochemistry
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Vanbrabant, Jeroen (author)
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Stoops, Erik (author)
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Vanmechelen, Eugeen (author)
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Dage, Jeffrey L (author)
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Teunissen, Charlotte E (author)
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(creator_code:org_t)
- 2021-12-04
- 2021
- English.
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In: Alzheimer's research & therapy. - : Springer Science and Business Media LLC. - 1758-9193. ; 13:1
- Related links:
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https://alzres.biome...
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https://gup.ub.gu.se...
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https://doi.org/10.1...
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Abstract
Subject headings
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- Studies using different assays and technologies showed highly promising diagnostic value of plasma phosphorylated (P-)tau levels for Alzheimer's disease (AD). We aimed to compare six P-tau Simoa assays, including three P-tau181 (Eli Lilly, ADx, Quanterix), one P-tau217 (Eli Lilly), and two P-tau231 (ADx, Gothenburg).We studied the analytical (sensitivity, precision, parallelism, dilution linearity, and recovery) and clinical (40 AD dementia patients, age 66±8years, 50%F; 40 age- and sex-matched controls) performance of the assays.All assays showed robust analytical performance, and particularly P-tau217 Eli Lilly; P-tau231 Gothenburg and all P-tau181 assays showed robust clinical performance to differentiate AD from controls, with AUCs 0.936-0.995 (P-tau231 ADx: AUC = 0.719). Results obtained with all P-tau181 assays, P-tau217 Eli Lilly assay, and P-tau231 Gothenburg assay strongly correlated (Spearman's rho > 0.86), while correlations with P-tau231 ADx results were moderate (rho < 0.65).P-tau isoforms can be measured robustly by several novel high-sensitive Simoa assays.
Subject headings
- MEDICIN OCH HÄLSOVETENSKAP -- Medicinska och farmaceutiska grundvetenskaper -- Neurovetenskaper (hsv//swe)
- MEDICAL AND HEALTH SCIENCES -- Basic Medicine -- Neurosciences (hsv//eng)
Keyword
- Alzheimer’s disease
- Analytical validation
- Blood biomarkers
- Clinical validation
- P-tau181
- P-tau217; P-tau231
- Phosphorylated tau proteins
- Simoa
- Ultra-sensitive immunoassays
Publication and Content Type
- ref (subject category)
- art (subject category)
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- By the author/editor
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Bayoumy, Sherif
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Verberk, Inge M ...
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den Dulk, Ben
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Hussainali, Zula ...
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Zwan, Marissa
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van der Flier, W ...
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show more...
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Ashton, Nicholas ...
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Zetterberg, Henr ...
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Blennow, Kaj, 19 ...
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Vanbrabant, Jero ...
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Stoops, Erik
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Vanmechelen, Eug ...
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Dage, Jeffrey L
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Teunissen, Charl ...
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show less...
- About the subject
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- MEDICAL AND HEALTH SCIENCES
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MEDICAL AND HEAL ...
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and Basic Medicine
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and Neurosciences
- Articles in the publication
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Alzheimer's rese ...
- By the university
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University of Gothenburg