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Digital remote asse...
Digital remote assessment of speech acoustics in cognitively unimpaired adults : feasibility, reliability and associations with amyloid pathology
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- van den Berg, Rosanne L. (författare)
- Amsterdam Neuroscience,Vrije Universiteit Amsterdam,Amsterdam UMC - Vrije Universiteit Amsterdam
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- de Boer, Casper (författare)
- Amsterdam Neuroscience,Amsterdam UMC - Vrije Universiteit Amsterdam
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- Zwan, Marissa D. (författare)
- Amsterdam Neuroscience,Amsterdam UMC - Vrije Universiteit Amsterdam
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visa fler...
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- Jutten, Roos J. (författare)
- Harvard Medical School
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- van Liere, Mariska (författare)
- Amsterdam Neuroscience,Amsterdam UMC - Vrije Universiteit Amsterdam
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- van de Glind, Marie Christine A.B.J. (författare)
- University Medical Center Groningen,Amsterdam Neuroscience,Amsterdam UMC - Vrije Universiteit Amsterdam,Erasmus University Medical Center
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- Dubbelman, Mark A. (författare)
- Harvard Medical School
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- Schlüter, Lisa Marie (författare)
- Amsterdam UMC - Vrije Universiteit Amsterdam,Amsterdam Neuroscience
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- van Harten, Argonde C. (författare)
- Amsterdam Neuroscience,Amsterdam UMC - Vrije Universiteit Amsterdam
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- Teunissen, Charlotte E. (författare)
- Amsterdam Neuroscience
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- van de Giessen, Elsmarieke (författare)
- Amsterdam Neuroscience,Academic Medical Center of University of Amsterdam (AMC)
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- Barkhof, Frederik (författare)
- University College London,Amsterdam Neuroscience
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- Collij, Lyduine E. (författare)
- Lund University,Lunds universitet,Klinisk minnesforskning,Forskargrupper vid Lunds universitet,LU profilområde: Proaktivt åldrande,Lunds universitets profilområden,Clinical Memory Research,Lund University Research Groups,LU Profile Area: Proactive Ageing,Lund University Profile areas,Amsterdam Neuroscience
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Robin, Jessica (författare)
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Simpson, William (författare)
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- Harrison, John E. (författare)
- Amsterdam UMC - Vrije Universiteit Amsterdam,King's College London
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- van der Flier, Wiesje M. (författare)
- Amsterdam Neuroscience,Amsterdam UMC - Vrije Universiteit Amsterdam
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- Sikkes, Sietske A.M. (författare)
- Vrije Universiteit Amsterdam,Amsterdam Neuroscience,Amsterdam UMC - Vrije Universiteit Amsterdam
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(creator_code:org_t)
- 2024
- 2024
- Engelska.
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Ingår i: Alzheimer's Research and Therapy. - 1758-9193. ; 16:1
- Relaterad länk:
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http://dx.doi.org/10... (free)
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https://lup.lub.lu.s...
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https://doi.org/10.1...
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Abstract
Ämnesord
Stäng
- Background: Digital speech assessment has potential relevance in the earliest, preclinical stages of Alzheimer’s disease (AD). We evaluated the feasibility, test-retest reliability, and association with AD-related amyloid-beta (Aβ) pathology of speech acoustics measured over multiple assessments in a remote setting. Methods: Fifty cognitively unimpaired adults (Age 68 ± 6.2 years, 58% female, 46% Aβ-positive) completed remote, tablet-based speech assessments (i.e., picture description, journal-prompt storytelling, verbal fluency tasks) for five days. The testing paradigm was repeated after 2–3 weeks. Acoustic speech features were automatically extracted from the voice recordings, and mean scores were calculated over the 5-day period. We assessed feasibility by adherence rates and usability ratings on the System Usability Scale (SUS) questionnaire. Test-retest reliability was examined with intraclass correlation coefficients (ICCs). We investigated the associations between acoustic features and Aβ-pathology, using linear regression models, adjusted for age, sex and education. Results: The speech assessment was feasible, indicated by 91.6% adherence and usability scores of 86.0 ± 9.9. High reliability (ICC ≥ 0.75) was found across averaged speech samples. Aβ-positive individuals displayed a higher pause-to-word ratio in picture description (B = -0.05, p = 0.040) and journal-prompt storytelling (B = -0.07, p = 0.032) than Aβ-negative individuals, although this effect lost significance after correction for multiple testing. Conclusion: Our findings support the feasibility and reliability of multi-day remote assessment of speech acoustics in cognitively unimpaired individuals with and without Aβ-pathology, which lays the foundation for the use of speech biomarkers in the context of early AD.
Ämnesord
- MEDICIN OCH HÄLSOVETENSKAP -- Medicinska och farmaceutiska grundvetenskaper -- Neurovetenskaper (hsv//swe)
- MEDICAL AND HEALTH SCIENCES -- Basic Medicine -- Neurosciences (hsv//eng)
Nyckelord
- Alzheimer’s disease
- Amyloid
- Digital biomarker
- Language
- Remote assessment
- Speech acoustics
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- art (ämneskategori)
- ref (ämneskategori)
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van den Berg, Ro ...
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de Boer, Casper
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Zwan, Marissa D.
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Jutten, Roos J.
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van Liere, Maris ...
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van de Glind, Ma ...
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Dubbelman, Mark ...
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Schlüter, Lisa M ...
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van Harten, Argo ...
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Teunissen, Charl ...
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van de Giessen, ...
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Barkhof, Frederi ...
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Collij, Lyduine ...
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Robin, Jessica
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Simpson, William
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Harrison, John E ...
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van der Flier, W ...
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Sikkes, Sietske ...
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- MEDICIN OCH HÄLSOVETENSKAP
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MEDICIN OCH HÄLS ...
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och Medicinska och f ...
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och Neurovetenskaper
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Alzheimer's Rese ...
- Av lärosätet
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Lunds universitet