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Evaluation of a nov...
Evaluation of a novel immunoassay to detect p-tau Thr217 in the CSF to distinguish Alzheimer disease from other dementias.
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- Hanes, Jozef (author)
- Axon Neuroscience SE
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- Kovac, Andrej (author)
- Axon Neuroscience SE
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- Kvartsberg, Hlin, 1987 (author)
- Gothenburg University,Göteborgs universitet,Institutionen för neurovetenskap och fysiologi, sektionen för psykiatri och neurokemi,Institute of Neuroscience and Physiology, Department of Psychiatry and Neurochemistry,Sahlgrenska University Hospital
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- Kontsekova, Eva (author)
- Axon Neuroscience SE
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- Fialova, Lubica (author)
- Axon Neuroscience SE
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- Katina, Stanislav (author)
- Axon Neuroscience SE
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- Kovacech, Branislav (author)
- Axon Neuroscience SE
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- Stevens, Eva (author)
- Axon Neuroscience SE
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- Hort, Jakub (author)
- Charles University in Prague
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- Vyhnalek, Martin (author)
- Charles University in Prague
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- Boonkamp, Lynn (author)
- Amsterdam UMC - Vrije Universiteit Amsterdam
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- Novak, Michal (author)
- Axon Neuroscience SE
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- Zetterberg, Henrik, 1973 (author)
- Gothenburg University,Göteborgs universitet,Institutionen för neurovetenskap och fysiologi, sektionen för psykiatri och neurokemi,Institute of Neuroscience and Physiology, Department of Psychiatry and Neurochemistry,Sahlgrenska University Hospital
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- Hansson, Oskar (author)
- Lund University,Lunds universitet,Klinisk minnesforskning,Forskargrupper vid Lunds universitet,Clinical Memory Research,Lund University Research Groups
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- Scheltens, Philip (author)
- Amsterdam UMC - Vrije Universiteit Amsterdam
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- Blennow, Kaj, 1958 (author)
- Gothenburg University,Göteborgs universitet,Institutionen för neurovetenskap och fysiologi, sektionen för psykiatri och neurokemi,Institute of Neuroscience and Physiology, Department of Psychiatry and Neurochemistry,Sahlgrenska University Hospital
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- Teunissen, Charlotte E (author)
- Amsterdam UMC - Vrije Universiteit Amsterdam
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- Zilka, Norbert (author)
- Axon Neuroscience SE
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(creator_code:org_t)
- 2020
- 2020
- English.
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In: Neurology. - 1526-632X. ; 95:22
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https://gup.ub.gu.se...
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Abstract
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- To investigate whether tau phosphorylated at Thr217 (p-tau T217) assay in CSF can distinguish patients with Alzheimer disease (AD) from patients with other dementias and healthy controls.We developed and validated a novel Simoa immunoassay to detect p-tau T217 in CSF. There was a total of 190 participants from 3 cohorts with AD (n = 77) and other neurodegenerative diseases (n = 69) as well as healthy participants (n = 44).The p-tau T217 assay (cutoff 242 pg/mL) identified patients with AD with accuracy of 90%, with 78% positive predictive value (PPV), 97% negative predictive value (NPV), 93% sensitivity, and 88% specificity, compared favorably with p-tau T181 ELISA (52 pg/mL), showing 78% accuracy, 58% PPV, 98% NPV, 71% specificity, and 97% sensitivity. The assay distinguished patients with AD from age-matched healthy controls (cutoff 163 pg/mL, 98% sensitivity, 93% specificity), similarly to p-tau T181 ELISA (cutoff 60 pg/mL, 96% sensitivity, 86% specificity). In patients with AD, we found a strong correlation between p-tau T217 and p-tau T181, total tau and β-amyloid 40, but not β-amyloid 42.This study demonstrates that p-tau T217 displayed better diagnostic accuracy than p-tau T181. The data suggest that the new p-tau T217 assay has potential as an AD diagnostic test in clinical evaluation.This study provides Class III evidence that a CSF immunoassay for p-tau T217 distinguishes patients with AD from patients with other dementias and healthy controls.
Subject headings
- MEDICIN OCH HÄLSOVETENSKAP -- Medicinska och farmaceutiska grundvetenskaper -- Neurovetenskaper (hsv//swe)
- MEDICAL AND HEALTH SCIENCES -- Basic Medicine -- Neurosciences (hsv//eng)
- MEDICIN OCH HÄLSOVETENSKAP -- Klinisk medicin -- Neurologi (hsv//swe)
- MEDICAL AND HEALTH SCIENCES -- Clinical Medicine -- Neurology (hsv//eng)
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- ref (subject category)
- art (subject category)
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Neurology
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To the university's database
- By the author/editor
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Hanes, Jozef
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Kovac, Andrej
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Kvartsberg, Hlin ...
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Kontsekova, Eva
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Fialova, Lubica
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Katina, Stanisla ...
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show more...
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Kovacech, Branis ...
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Stevens, Eva
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Hort, Jakub
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Vyhnalek, Martin
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Boonkamp, Lynn
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Novak, Michal
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Zetterberg, Henr ...
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Hansson, Oskar
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Scheltens, Phili ...
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Blennow, Kaj, 19 ...
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Teunissen, Charl ...
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Zilka, Norbert
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- About the subject
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- MEDICAL AND HEALTH SCIENCES
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MEDICAL AND HEAL ...
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and Basic Medicine
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and Neurosciences
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- MEDICAL AND HEALTH SCIENCES
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MEDICAL AND HEAL ...
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and Clinical Medicin ...
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and Neurology
- Articles in the publication
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Neurology
- By the university
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University of Gothenburg
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Lund University