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Developments in predictive biomarker testing and targeted therapy in advanced stage non-small cell lung cancer and their application across European countries

de Jager, Vincent D. (författare)
Department of Pathology and Medical Biology, University Medical Center Groningen, University of Groningen, Groningen, Netherlands
Timens, Wim (författare)
Department of Pathology and Medical Biology, University Medical Center Groningen, University of Groningen, Groningen, Netherlands
Bayle, Arnaud (författare)
Oncostat U1018, Inserm, Paris-Saclay University, Gustave Roussy, Villejuif, France
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Botling, Johan (författare)
Department of Laboratory Medicine, Institute of Biomedicine, Sahlgrenska Academy of University of Gothenburg, Gothenburg, Sweden
Brcic, Luka (författare)
Diagnostic and Research Institute of Pathology, Medical University of Graz, Graz, Austria
Büttner, Reinhard (författare)
Institute of Medical Genetics and Applied Genomics, University of Tuebingen, Tuebingen, Germany
Fernandes, Maria Gabriela O. (författare)
Pulmonology Department, Centro Hospitalar Universitário de São João, Porto, Portugal
Havel, Libor (författare)
Charles University and Thomayer Hospital, Prague, Czech Republic
Hochmair, Maximilian J. (författare)
Karl Landsteiner Institute of Lung Research and Pulmonary Oncology, Klinik Floridsdorf, Vienna, Austria; Department of Respiratory and Critical Care Medicine, Klinik Floridsdorf, Vienna Healthcare Group, Vienna, Austria
Hofman, Paul (författare)
IHU RespirERA, FHU OncoAge, Nice University Hospital, Côte d'Azur University, Nice, France
Janssens, Annelies (författare)
Department of Oncology, University Hospital Antwerp, University of Antwerp, Edegem, Belgium
Johansson, Mikael (författare)
Umeå universitet,Onkologi
van Kempen, Léon (författare)
Department of Pathology, University Hospital Antwerp, University of Antwerp, Edegem, Belgium
Kern, Izidor (författare)
Laboratory for Cytology and Pathology, University Clinic Golnik, Golnik, Slovenia
Lopez-Rios, Fernando (författare)
Hospital Universitario 12 de Octubre, Universidad Complutense de Madrid, Research Institute Hospital 12 de Octubre (i+12), Ciberonc, Madrid, Spain
Lüchtenborg, Margreet (författare)
National Disease Registration Service, NHS England, London, United Kingdom; Centre for Cancer, Society & Public Health, King's College London, London, United Kingdom
Machado, José Carlos (författare)
Institute of Molecular Pathology and Immunology of the University of Porto (IPATIMUP), Porto, Portugal; Faculty of Medicine of the University of Porto, Institute for Research and Innovation in Health (i3S), Porto, Portugal
Mohorcic, Katja (författare)
University Clinic of Respiratory and Allergic Diseases, Golnik, Slovenia
Paz-Ares, Luis (författare)
Hospital Universitario 12 de Octubre, Universidad Complutense de Madrid, H12O-CNIO Lung Cancer Clinical Research Unit, Research Institute Hospital 12 de Octubre (i+12)/Spanish National Cancer Research Center (CNIO), Ciberonc, Madrid, Spain
Popat, Sanjay (författare)
Lung Unit, Royal Marsden NHS Trust, London, United Kingdom
Ryška, Aleš (författare)
The Fingerland Department of Pathology, Charles University Medical Faculty and University Hospital, Czech Republic
Taniere, Phillipe (författare)
Department of Histopathology, University Hospitals Birmingham NHS Foundation Trust, Birmingham, United Kingdom
Wolf, Jürgen (författare)
Lung Cancer Group Cologne, Department I for Internal Medicine and Center for Integrated Oncology Cologne/Bonn, University Hospital Cologne, Cologne, Germany
Schuuring, Ed (författare)
Department of Pathology and Medical Biology, University Medical Center Groningen, University of Groningen, Groningen, Netherlands
van der Wekken, Anthonie J. (författare)
Department of Pulmonary Diseases and Tuberculosis, University Medical Center Groningen, University of Groningen, Groningen, Netherlands
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 (creator_code:org_t)
Elsevier, 2024
2024
Engelska.
Ingår i: The Lancet Regional Health. - : Elsevier. - 2666-7762. ; 38
Relaterad länk:
https://doi.org/10.1...
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https://umu.diva-por... (primary) (Raw object)
https://urn.kb.se/re...
https://doi.org/10.1...
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  • Forskningsöversikt (refereegranskat)
Abstract Ämnesord
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  • In the past two decades, the treatment of metastatic non-small cell lung cancer (NSCLC), has undergone significant changes due to the introduction of targeted therapies and immunotherapy. These advancements have led to the need for predictive molecular tests to identify patients eligible for targeted therapy. This review provides an overview of the development and current application of targeted therapies and predictive biomarker testing in European patients with advanced stage NSCLC. Using data from eleven European countries, we conclude that recommendations for predictive testing are incorporated in national guidelines across Europe, although there are differences in their comprehensiveness. Moreover, the availability of recently EMA-approved targeted therapies varies between European countries. Unfortunately, routine assessment of national/regional molecular testing rates is limited. As a result, it remains uncertain which proportion of patients with metastatic NSCLC in Europe receive adequate predictive biomarker testing. Lastly, Molecular Tumor Boards (MTBs) for discussion of molecular test results are widely implemented, but national guidelines for their composition and functioning are lacking. The establishment of MTB guidelines can provide a framework for interpreting rare or complex mutations, facilitating appropriate treatment decision-making, and ensuring quality control.

Ämnesord

MEDICIN OCH HÄLSOVETENSKAP  -- Klinisk medicin -- Cancer och onkologi (hsv//swe)
MEDICAL AND HEALTH SCIENCES  -- Clinical Medicine -- Cancer and Oncology (hsv//eng)

Nyckelord

Europe
Non-small cell lung cancer
Predictive biomarker testing
Targeted therapy

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