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Sökning: onr:"swepub:oai:DiVA.org:uu-507549" > Exploring the Compl...

Exploring the Complex Relationship between Gut Microbiota and Risk of Colorectal Neoplasia Using Bidirectional Mendelian Randomization Analysis

Li, Wanxin (författare)
Zhejiang Univ, Analyt Affiliated Hosp 2, Ctr Clin Big Data, Sch Med,Dept Big Data Hlth Sci Sch Publ Hlth, Hangzhou, Peoples R China.
Zhou, Xuan (författare)
Zhejiang Univ, Analyt Affiliated Hosp 2, Ctr Clin Big Data, Sch Med,Dept Big Data Hlth Sci Sch Publ Hlth, Hangzhou, Peoples R China.
Yuan, Shuai (författare)
Karolinska Institutet
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Wang, Lijuan (författare)
Zhejiang Univ, Analyt Affiliated Hosp 2, Ctr Clin Big Data, Sch Med,Dept Big Data Hlth Sci Sch Publ Hlth, Hangzhou, Peoples R China.
Yu, Lili (författare)
Zhejiang Univ, Analyt Affiliated Hosp 2, Ctr Clin Big Data, Sch Med,Dept Big Data Hlth Sci Sch Publ Hlth, Hangzhou, Peoples R China.
Sun, Jing (författare)
Zhejiang Univ, Analyt Affiliated Hosp 2, Ctr Clin Big Data, Sch Med,Dept Big Data Hlth Sci Sch Publ Hlth, Hangzhou, Peoples R China.
Chen, Jie (författare)
Zhejiang Univ, Analyt Affiliated Hosp 2, Ctr Clin Big Data, Sch Med,Dept Big Data Hlth Sci Sch Publ Hlth, Hangzhou, Peoples R China.
Xiao, Qian (författare)
Zhejiang Univ, Colorectal Surg & Oncol, Key Lab Canc Prevent & Intervent Minist Educ, Sch Med,Affiliated Hosp 2, Hangzhou, Peoples R China.
Wan, Zhongxiao (författare)
Soochow Univ, Sch Publ Hlth, Dept Nutr & Food Hyg, Suzhou, Peoples R China.
Zheng, Ju-Sheng (författare)
Westlake Univ, Sch Life Sci, Key Lab Growth Regulat & Translat Res Zhejiang Pro, Hangzhou, Peoples R China.
Zhang, Cai-Xia (författare)
Sun Yat Sen Univ, Sch Publ Hlth, Dept Epidemiol, Guangzhou, Peoples R China.
Larsson, Susanna C. (författare)
Karolinska Institutet,Uppsala universitet,Medicinsk epidemiologi,Karolinska Inst, Inst Environm Med, Unit Cardiovasc & Nutr Epidemiol, Stockholm, Sweden.
Farrington, Susan M. (författare)
Univ Edinburgh, Inst Genet & Canc, Colon Canc Genet Grp, Edinburgh, Scotland.;Univ Edinburgh, Inst Genet & Canc, Canc Res UK Edinburgh Canc Res Ctr, Edinburgh, Scotland.
Law, Philip (författare)
Inst Canc Res, Div Genet & Epidemiol, London, England.
Houlston, Richard S. (författare)
Inst Canc Res, Div Genet & Epidemiol, London, England.
Tomlinson, Ian (författare)
Univ Edinburgh, Inst Genet & Canc, Canc Res UK Edinburgh Canc Res Ctr, Edinburgh, Scotland.
Ding, Ke-Feng (författare)
Zhejiang Univ, Colorectal Surg & Oncol, Key Lab Canc Prevent & Intervent Minist Educ, Sch Med,Affiliated Hosp 2, Hangzhou, Peoples R China.
Dunlop, Malcolm G. (författare)
Univ Edinburgh, Inst Genet & Canc, Colon Canc Genet Grp, Edinburgh, Scotland.;Univ Edinburgh, Inst Genet & Canc, Canc Res UK Edinburgh Canc Res Ctr, Edinburgh, Scotland.;Univ Edinburgh, Inst Genet & Canc, MRC Human Genet Unit, Edinburgh, Scotland.
Theodoratou, Evropi (författare)
Univ Edinburgh, Inst Genet & Canc, Colon Canc Genet Grp, Edinburgh, Scotland.;Univ Edinburgh, Usher Inst, Ctr Global Hlth, Edinburgh, Scotland.
Li, Xue (författare)
Zhejiang Univ, Analyt Affiliated Hosp 2, Ctr Clin Big Data, Sch Med,Dept Big Data Hlth Sci Sch Publ Hlth, Hangzhou, Peoples R China.;Univ Edinburgh, Inst Genet & Canc, Colon Canc Genet Grp, Edinburgh, Scotland.;Key Lab Intelligent Prevent Med Zhejiang Prov, Hangzhou, Peoples R China.;Zhejiang Univ, Sch Publ Hlth, Sh Med, Hangzhou, Peoples R China.;Zhejiang Univ, Affiliated Hosp, Sch Med, Hangzhou, Peoples R China.;Univ Edinburgh, Usher Inst, Edinburgh, Scotland.
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Karolinska Institutet Zhejiang Univ, Analyt Affiliated Hosp 2, Ctr Clin Big Data, Sch Med,Dept Big Data Hlth Sci Sch Publ Hlth, Hangzhou, Peoples R China (creator_code:org_t)
American Association For Cancer Research (AACR), 2023
2023
Engelska.
Ingår i: Cancer Epidemiology, Biomarkers and Prevention. - : American Association For Cancer Research (AACR). - 1055-9965 .- 1538-7755. ; 32:6, s. 809-817
Relaterad länk:
https://doi.org/10.1...
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https://uu.diva-port... (primary) (Raw object)
https://urn.kb.se/re...
https://doi.org/10.1...
http://kipublication...
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  • Tidskriftsartikel (refereegranskat)
Abstract Ämnesord
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  • Background: Human gut microbiome has complex relation-ships with the host, contributing to metabolism, immunity, and carcinogenesis.Methods: Summary-level data for gut microbiota and metabo-lites were obtained from MiBioGen, FINRISK and human meta-bolome consortia. Summary-level data for colorectal cancer were derived from a genome-wide association study meta-analysis. In forward Mendelian randomization (MR), we employed genetic instrumental variables (IV) for 24 gut microbiota taxa and six bacterial metabolites to examine their causal relationship with colorectal cancer. We also used a lenient threshold for nine apriori gut microbiota taxa as secondary analyses. In reverse MR, we explored association between genetic liability to colorectal neoplasia and abundance of microbiota studied above using 95, 19, and 7 IVs for colorectal cancer, adenoma, and polyps, respectively.Results: Forward MR did not find evidence indicating causal relationship between any of the gut microbiota taxa or six bacterial metabolites tested and colorectal cancer risk. However, reverse MR supported genetic liability to colorectal adenomas was causally related with increased abundance of two taxa: Gammaproteobacteria (b = 0.027, which represents a 0.027 increase in log-transformed relative abundance values of Gam-maproteobacteria for per one-unit increase in log OR of adenoma risk; P = 7.06x10-8), Enterobacteriaceae (b = 0.023, P = 1.29x10-5).Conclusions: We find genetic liability to colorectal neoplasia may be associated with abundance of certain microbiota taxa. It is more likely that subset of colorectal cancer genetic liability variants changes gut biology by influencing both gut microbiota and colo-rectal cancer risk.Impact: This study highlights the need of future complemen-tary studies to explore causal mechanisms linking both host genetic variation with gut microbiome and colorectal cancer susceptibility.

Ämnesord

MEDICIN OCH HÄLSOVETENSKAP  -- Klinisk medicin -- Cancer och onkologi (hsv//swe)
MEDICAL AND HEALTH SCIENCES  -- Clinical Medicine -- Cancer and Oncology (hsv//eng)
MEDICIN OCH HÄLSOVETENSKAP  -- Klinisk medicin -- Gastroenterologi (hsv//swe)
MEDICAL AND HEALTH SCIENCES  -- Clinical Medicine -- Gastroenterology and Hepatology (hsv//eng)

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