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Plasma p-tau212 ant...
Plasma p-tau212 antemortem diagnostic performance and prediction of autopsy verification of Alzheimer's disease neuropathology.
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- Kac, Przemyslaw R., 1995 (author)
- Gothenburg University,Göteborgs universitet,Institutionen för neurovetenskap och fysiologi, sektionen för psykiatri och neurokemi,Institute of Neuroscience and Physiology, Department of Psychiatry and Neurochemistry
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- Gonzalez-Ortiz, Fernando, 1990 (author)
- Gothenburg University,Göteborgs universitet,Institutionen för neurovetenskap och fysiologi, sektionen för psykiatri och neurokemi,Institute of Neuroscience and Physiology, Department of Psychiatry and Neurochemistry
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Emeršič, Andreja (author)
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- Dulewicz, Maciej, 1990 (author)
- Gothenburg University,Göteborgs universitet,Institutionen för neurovetenskap och fysiologi, sektionen för psykiatri och neurokemi,Institute of Neuroscience and Physiology, Department of Psychiatry and Neurochemistry
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- Koutarapu, Srinivas, 1987 (author)
- Gothenburg University,Göteborgs universitet,Institutionen för neurovetenskap och fysiologi, sektionen för psykiatri och neurokemi,Institute of Neuroscience and Physiology, Department of Psychiatry and Neurochemistry
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Turton, Michael (author)
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An, Yang (author)
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Smirnov, Denis (author)
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Kulczyńska-Przybik, Agnieszka (author)
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Varma, Vijay R (author)
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- Ashton, Nicholas J. (author)
- Gothenburg University,Göteborgs universitet,Institutionen för neurovetenskap och fysiologi, sektionen för psykiatri och neurokemi,Institute of Neuroscience and Physiology, Department of Psychiatry and Neurochemistry
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- Montoliu-Gaya, Laia (author)
- Gothenburg University,Göteborgs universitet,Institutionen för neurovetenskap och fysiologi, sektionen för psykiatri och neurokemi,Institute of Neuroscience and Physiology, Department of Psychiatry and Neurochemistry
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- Camporesi, Elena (author)
- Gothenburg University,Göteborgs universitet,Institutionen för neurovetenskap och fysiologi, sektionen för psykiatri och neurokemi,Institute of Neuroscience and Physiology, Department of Psychiatry and Neurochemistry
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Winkel, Izabela (author)
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Paradowski, Bogusław (author)
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Moghekar, Abhay (author)
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Troncoso, Juan C (author)
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Lashley, Tammaryn (author)
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- Brinkmalm, Gunnar (author)
- Gothenburg University,Göteborgs universitet,Institutionen för neurovetenskap och fysiologi, sektionen för psykiatri och neurokemi,Institute of Neuroscience and Physiology, Department of Psychiatry and Neurochemistry
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Resnick, Susan M (author)
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Mroczko, Barbara (author)
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- Kvartsberg, Hlin, 1987 (author)
- Gothenburg University,Göteborgs universitet,Institutionen för neurovetenskap och fysiologi, sektionen för psykiatri och neurokemi,Institute of Neuroscience and Physiology, Department of Psychiatry and Neurochemistry
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Gregorič Kramberger, Milica (author)
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- Hanrieder, Jörg, 1980 (author)
- Gothenburg University,Göteborgs universitet,Institutionen för neurovetenskap och fysiologi, sektionen för psykiatri och neurokemi,Institute of Neuroscience and Physiology, Department of Psychiatry and Neurochemistry
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Čučnik, Saša (author)
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Harrison, Peter (author)
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- Zetterberg, Henrik, 1973 (author)
- Gothenburg University,Göteborgs universitet,Institutionen för neurovetenskap och fysiologi, sektionen för psykiatri och neurokemi,Institute of Neuroscience and Physiology, Department of Psychiatry and Neurochemistry
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Lewczuk, Piotr (author)
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Thambisetty, Madhav (author)
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Rot, Uroš (author)
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Galasko, Douglas (author)
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- Blennow, Kaj, 1958 (author)
- Gothenburg University,Göteborgs universitet,Institutionen för neurovetenskap och fysiologi, sektionen för psykiatri och neurokemi,Institute of Neuroscience and Physiology, Department of Psychiatry and Neurochemistry
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- Karikari, Thomas (author)
- Gothenburg University,Göteborgs universitet,Institutionen för neurovetenskap och fysiologi, sektionen för psykiatri och neurokemi,Institute of Neuroscience and Physiology, Department of Psychiatry and Neurochemistry
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(creator_code:org_t)
- 2024
- 2024
- English.
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In: Nature communications. - 2041-1723. ; 15:1
- Related links:
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https://gup.ub.gu.se...
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https://doi.org/10.1...
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Abstract
Subject headings
Close
- Blood phosphorylated tau (p-tau) biomarkers, including p-tau217, show high associations with Alzheimer's disease (AD) neuropathologic change and clinical stage. Certain plasma p-tau217 assays recognize tau forms phosphorylated additionally at threonine-212, but the contribution of p-tau212 alone to AD is unknown. We developed a blood-based immunoassay that is specific to p-tau212 without cross-reactivity to p-tau217. Here, we examined the diagnostic utility of plasma p-tau212. In five cohorts (n=388 participants), plasma p-tau212 showed high performances for AD diagnosis and for the detection of both amyloid and tau pathology, including at autopsy as well as in memory clinic populations. The diagnostic accuracy and fold changes of plasma p-tau212 were similar to those for p-tau217 but higher than p-tau181 and p-tau231. Immunofluorescent staining of brain tissue slices showed prominent p-tau212 reactivity in neurofibrillary tangles that co-localized with p-tau217 and p-tau202/205. These findings support plasma p-tau212 as a peripherally accessible biomarker of AD pathophysiology.
Subject headings
- MEDICIN OCH HÄLSOVETENSKAP -- Medicinska och farmaceutiska grundvetenskaper -- Neurovetenskaper (hsv//swe)
- MEDICAL AND HEALTH SCIENCES -- Basic Medicine -- Neurosciences (hsv//eng)
Keyword
- Humans
- Alzheimer Disease
- diagnosis
- Neuropathology
- Plasma
- Neurofibrillary Tangles
- Autopsy
- tau Proteins
- Biomarkers
- Amyloid beta-Peptides
Publication and Content Type
- ref (subject category)
- art (subject category)
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To the university's database
- By the author/editor
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Kac, Przemyslaw ...
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Gonzalez-Ortiz, ...
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Emeršič, Andreja
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Dulewicz, Maciej ...
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Koutarapu, Srini ...
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Turton, Michael
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show more...
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An, Yang
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Smirnov, Denis
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Kulczyńska-Przyb ...
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Varma, Vijay R
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Ashton, Nicholas ...
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Montoliu-Gaya, L ...
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Camporesi, Elena
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Winkel, Izabela
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Paradowski, Bogu ...
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Moghekar, Abhay
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Troncoso, Juan C
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Lashley, Tammary ...
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Brinkmalm, Gunna ...
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Resnick, Susan M
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Mroczko, Barbara
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Kvartsberg, Hlin ...
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Gregorič Kramber ...
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Hanrieder, Jörg, ...
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Čučnik, Saša
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Harrison, Peter
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Zetterberg, Henr ...
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Lewczuk, Piotr
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Thambisetty, Mad ...
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Rot, Uroš
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Galasko, Douglas
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Blennow, Kaj, 19 ...
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Karikari, Thomas
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show less...
- About the subject
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- MEDICAL AND HEALTH SCIENCES
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MEDICAL AND HEAL ...
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and Basic Medicine
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and Neurosciences
- Articles in the publication
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Nature communica ...
- By the university
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University of Gothenburg
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Karolinska Institutet